| 1. |  chuggaaconroy | 23,448,003 | 1 Year Anniversary: Mother 3 - Lost Episode - Steel Mechorilla Failed Attempts | 10:56 |
| 2. | NintendoCapriSun | 4,708,674 | Mother [6]: Not Mother 3 | 18:20 |
| 3. | Super Beard Bros | 3,231,088 | Interview with Clyde "Tomato" & Heidi "Poe" Mandelin | Super Beard Bros. | 57:53 |
| 4. |  Jiraiya | 2,924,418 | Personagens Que Tiveram um Destino PIOR Que a M0RTE | 12:24 |
| 5. | Level UP | 2,640,277 | Kirby accidentally breaks into Link's house on purpose | 2:05 |
| 6. | oddheader | 2,560,613 | 10 Crazy Hidden Dialogue Messages In Video Games | 11:12 |
| 7. | Vinesauce: The Full Sauce | 2,408,485 | [Vinesauce] Vinny - Mother 3 Corruptions | 1:22:34 |
| 8. | Zico Tops | 2,400,733 | 7 Finales Aterradores de Videojuegos que Nadie Entendió (Explicados) #3 | 17:07 |
| 9. |  リゼ・ヘルエスタ -Lize Helesta- | 2,316,241 | 【MOTHER3】奇妙で、おもしろい。そして、せつない。#11【にじさんじ/リゼ・ヘルエスタ】 | 4:15:28 |
| 10. | irikachana | 2,098,038 | Mischievous Blues (3i Mix) || MOTHER 3 | 2:50 |
| 11. | Curiomatic | 1,800,501 | 🎭"What expressions lie hidden behind his mask? ...And more importantly, who is he?"😶🌫️#mother3 | 0:23 |
| 12. | joshscorcher | 1,507,672 | Top Ten Saddest Video Game Moments Part 2 (4-1) | 18:18 |
| 13. |  Super Eyepatch Wolf | 1,374,368 | How Mother 3 Breaks You | 43:38 |
| 14. | Thane Gaming | 1,311,803 | Does Game Boy Advance on Switch = MOTHER 3? - Thane Gaming | 6:06 |
| 15. | Okayu Ch. 猫又おかゆ | 1,288,718 | 【MOTHER3】最後の針を抜く日が来た #最終回【猫又おかゆ/ホロライブ】 | 4:40:41 |
| 16. |  N Deluxe | 1,265,391 | Los 10 MEJORES RPG de Nintendo | NDeluxe | 13:45 |
| 17. | DidYouKnowGaming | 1,257,451 | Game Boy Advance Games (GBA) Mario, Zelda, Pokemon & more | 29:24 |
| 18. | Aligator1024 | 1,243,268 | Mother 3 / DEBUG ROOM | 3:11 |
| 19. | わくドキTV | 1,210,717 | 【悪こそ正義】闇堕ち・ダークサイド化してしまったゲームキャラ 4選 | 12:22 |
| 20. | Ridgway Films | 1,207,790 | Mother 3: The Movie (April Fool's '12) | 1:21:33 |
| 21. | NicoB | 1,092,882 | NO CRYING UNTIL THE END - Let's Play - Mother 3 - 16 - Ending | 1:22:03 |
| 22. |  outsidexbox | 989,761 | 7 Stupidest Things That Blocked Your Path 😡 | 15:19 |
| 23. | ぶいちゅーばー切り抜き | 942,515 | 【面白まとめ】ニートへの〇意が高い釈迦やべに達に動揺するおぼｗ【八雲べに/らっだぁ/MOTHER3/やにスパ リベンジハードコア/ぶいすぽ 切り抜き】 | 21:27 |
| 24. | 【公認】ボドカ切り抜き集 | 907,983 | 【ボドカ／切り抜き】奈羅花に会えて一線を越えてしまうMOTHER3にもう驚愕するしかないチームメンエス | 1:52 |
| 25. | GameXplain | 788,949 | Up to $20 Off BIG Games for Mar10 Day! + Nintendo Fixed Mother 3 NSO Icon Glitch! | 1:57 |
| 26. | 【吹いたら負け】葛葉先生のしくじり【切り抜き】 | 760,811 | 【ダイジェスト】笑い無しでホラゲ攻略に挑むが終始笑いが止まらない葛葉達ｗｗｗ【にじさんじ/切り抜き/Vtuber/釈迦/sasatikk/MOTHER3/Lethal Company 】 | 1:22:26 |
| 27. | whoisthisgit | 716,549 | The Most Powerful Characters In Gaming Ever # 15 Extra | 4:12 |
| 28. |  PaperBatVG | 666,084 | Mother 3 Ep.38 - The Final Needle | 1:00:24 |
| 29. | けーたいぷ | 660,505 | ◆MOTHER3を思い出しつつ実況プレイ part45(おわり) | 47:20 |
| 30. | MonkeyNess | 637,970 | HE’S GOING TO MEET SHIGESATO ITOI… | 0:49 |
| 31. |  Metkuratsu Mizuiro | 627,967 | Earthbound 2/Mother 3 - [Hacked Fight #6]: Vs Giygas, Porky & The Masked Man | 8:06 |
| 32. | Deon | 625,134 | Let's Play Mother 3 Part 79: The Final Video | 7:44 |
| 33. | SomecallmeJohnny | 618,787 | Johnny vs. Mother 3 | 27:31 |
| 34. | Moonsidian | 590,905 | Mother 3 - Chapter 7 Bosses (without Kumatora) | 17:54 |
| 35. | じゃすぱー切り抜き4号 | 552,578 | クラッチ君とMOTHER3にドッキリを仕掛けるだるまいずごっど、釈迦、XQQとじゃすぱー【切り抜き】 | 8:54 |
| 36. | Korone Ch. 戌神ころね | 547,310 | #5【GBA】ついに最終回…ありがとう「MOTHER3」【戌神ころね/ホロライブ】 | 5:03:06 |
| 37. |  Espyo | 530,049 | PK Rhythm teaser trailer | 0:54 |
| 38. | Nintendude | 512,314 | Mother 3 16-Hit Combo Compilation [Re-uploaded] | 22:00 |
| 39. | brinmat | 509,354 | Mother 3 - Final Boss and Full Ending (English, 480p) | 47:53 |
| 40. | カオゲCh | 507,138 | 【GBA】MOTHER3 全ボス戦集 / Mother 3 All Boss Fight | 1:17:51 |
| 41. | adricarra | 485,397 | MOTHER 3 (Esp) -Parte 43 [Final]- La última aguja | 1:15:42 |
| 42. | Nerrel | 458,813 | Mother 3 - Localizers HATE This One Weird Game! | 15:24 |
| 43. | RanguGamer | 457,960 | Let´s Play Mother3 FINALE ¡Partiendo la Madre! | 2:33:32 |
| 44. | vinesauce | 457,106 | [Vinesauce] Vinny - Mother 3 | 42:13 |
| 45. | Wentworth Bros | 445,859 | The saddest story in video game HISTORY #lucas #ness #earthbound #mother3 #nintendo #smashbros | 0:34 |
| 46. | rabbidluigi | 423,327 | Top 5 Strangest Unused Content in Video Games | 12:33 |
| 47. |  Shadow! | 391,606 | Momentos tristes en videojuegos | Sexy TOP 10 | 26:34 |
| 48. | RetroSpecter | 377,284 | Mother 3 Remix: Unfounded Revenge/Smashing Song of Praise (Lucas Remashed) | 3:48 |
| 49. |  EugeneSagaz | 367,870 | ХАОС ИН ДА ХАУС в Mother #3 | 27:19 |
| 50. | Skawo | 364,233 | Mother 3 - FINAL - There's An Island Nowhere | 26:55 |
| 51. | KingK | 361,366 | Mother 3 Retrospective | 34:42 |
| 52. | はっぱちゃんのゲーム部屋【MOTHERゆっくり解説】 | 354,457 | スノーマンでお馴染み!歴代MOTHERの雪エリア | 5:56 |
| 53. | EmpoleMew | 343,786 | Mother 3: PK Ground Does Not Affect The Porky Statue | 0:37 |
| 54. | Shesez | 336,932 | Unused Content Discovered Out of Bounds | Mother 3 - Ft. [Vinesauce] Vinny | 13:19 |
| 55. | Lauren the Flute | 336,860 | Lauren plays the LIFELIKE demo! A MOTHER-inspired indie RPG | 3:27:28 |
| 56. | The Noble Demon | 330,274 | Mother 3: Butch and the Villagers Arrangement | 2:35 |
| 57. | Davidvinc RPGs | 326,684 | JRPG News - Tales of Arise Release Date, New Mother 3 Translation, Saga Frontier Remastered, Nier! | 6:22 |
| 58. | CubeGame | 322,186 | 実はワンパンで倒せるゲームのボス | 8:03 |
| 59. | こーすけ | 320,701 | 【実況】読んでいくMOTHER3 #LAST EARTHBOUND2 #LAST | 55:46 |
| 60. | MegaHarv | 301,776 | Vertical Mother 3 Livestream Guide Part 3 (Chapter 8) | 4:27:24 |
| 61. | NintendoComplete | 298,250 | ♫16 MELODIES (Mother 3) SNES Arrangement - NintendoComplete | 3:12 |
| 62. | AntDude | 293,542 | Japanese Exclusive Nintendo Games | Imports from the Land of the Rising Sun | 45:48 |
| 63. | Tazmi | 293,493 | "F-F-Fire!" + "Forest of Flames" Mother 3 (Smash Bros. Fanmade Cover) | 2:26 |
| 64. |  Slyzer | 272,230 | MOTHER 3: Salsa's Revenge | 0:18 |
| 65. | Liquid Goth | 271,417 | Operation Intrude N313 (Metal Gear) - Mother 3 Remix | 0:12 |
| 66. | Nintendo 公式チャンネル | 268,117 | MOTHER3（ゲームボーイアドバンス Nintendo Switch Online） [Nintendo Direct ソフトメーカーラインナップ 2024.2.21] | 1:07 |
| 67. |  Lazy Blue | 267,069 | MOTHER 3 Finale (Final Boss and Ending) - Full Gameplay - No Commentary | 43:31 |
| 68. | Boomerang78 | 259,190 | Mother 3: 027 - Brave New World | 9:03 |
| 69. |  Plano de Juego | 247,269 | La Hermosa Ambigüedad de Mother 3 | PLANO DE JUEGO | 21:38 |
| 70. | PKLucas531 | 242,813 | MOTHER 3: Wess Dance | 1:16 |
| 71. | TheLunatikguy | 235,637 | The Final Needle - Mother 3 - Part 53 [FINALE] | 48:06 |
| 72. | MetalJesusRocks | 235,524 | More Repros, HOMEBREW & Hacked Games | 22:09 |
| 73. | Tork110 | 235,347 | Mother 3 Cast And Credits | 12:39 |
| 74. | Tom Fawkes | 225,080 | Mother 3 | The End of the World [43/Finale] | 26:41 |
| 75. |  Patafoin | 224,113 | PREVIEW of Incoming Animation _ Knuckles / Pokemon / Mother 3 | 6:16 |
| 76. | Tororo Ch. 猫麦とろろ | 219,712 | 【VCRGTA】日頃の恨み(感謝)をぶつける麦かもです！【猫麦とろろ/赤見かるび/乾伸一郎/叶/恭一郎/Clutch_Fi/黒炭酸/Sasatikk/釈迦/Selly/Mother3/らっだぁ】 | 12:15 |
| 77. | Clyde Mandelin | 218,639 | MOTHER 3 - OJ & Lucas Japanese Voice Clip | 0:23 |
| 78. | SuperMCGamer | 218,132 | MC LPs - Mother 3 - Memories of Life - 50 | 1:09:49 |
| 79. | ゲーム夜話 | 212,103 | 【マザー3】哀しい物語の結末【第117回後編-ゲーム夜話】 | 18:16 |
| 80. | Superteletubbies64 | 207,707 | Cursed Roblox images but with Earthbound and Mother 3 music (Shorter version) | 10:19 |
| 81. | 夜見れな/yorumi rena【にじさんじ所属】 | 199,143 | #08『MOTHER3』第7章~ 針を抜いてます（後編）…初見プレイ【夜見れな／にじさんじ】 | 8:40:10 |
| 82. | Spawn Wave | 199,036 | So Nintendo And Mother 3 Were Trending Online... | 8:04 |
| 83. | Stop Skeletons From Fighting | 195,881 | A Brief History of Reggie Not Announcing Mother 3 | Mini Mortem [SSFF] | 8:53 |
| 84. | maidenrikku123 | 194,852 | Emuparadise y Nintendo contra los emuladores y roms (Mi opinion) | 7:41 |
| 85. | Bulby | 191,586 | Unfounded Revenge 8 Bit Remix - Mother 3 | 1:44 |
| 86. | dumdumlaw | 191,277 | Mother3 OST- Love Theme【愛のテーマ】EXTENDED | 30:30 |
| 87. |  FalKKonE | 189,115 | Mother 3 - Unfounded Revenge 【Intense Symphonic Metal Cover】 | 3:46 |
| 88. | Salmence | 185,293 | Mother 3 (Blind) - Finale | 1:15:15 |
| 89. | Carls493 | 184,809 | Mother 3: Debug Mode Guide w/ Annotations | 6:16 |
| 90. |  Su amiguillo Soac | 183,724 | Memorias que nunca mueren | Mother 3- [#26 - Final extendido] | 2:09:46 |
| 91. | Leadhead | 179,308 | Understanding Nintendo's Weirdest Game | 19:43 |
| 92. |  El Calabozo del Nigromante | 172,823 | La Historia de Mother 3 - LO QUE TE PERDISTE | 47:41 |
| 93. | Alexander Pale | 171,981 | MOTHER 3 - Final Boss (2/2) | 9:12 |
| 94. | Nintendo Life | 168,549 | Hope Isn't Lost For English MOTHER 3 On Switch... | 13:28 |
| 95. | コメ付きをゆっくり実況 【RTA】 | 164,318 | 【コメ付き】 MOTHER 3 マザースリーをゆっくり実況 【RTA】 | 6:41:23 |
| 96. | Nafan | 160,815 | Mother 3 Analysis | 3:15:26 |
| 97. | That Video Games Show | 160,221 | Good Games Stuck On GBA | 18:09 |
| 98. | 田中あずまろ | 158,745 | 【ゆっくり鬱ゲー？解説】MOTHER３が鬱ゲーと呼ばれた理由 | 6:54 |
| 99. | Lily Arciniega | 156,069 | Mother 3: Mind of a Thief (Piano jazz arrangement) | 2:24 |
| 100. | 444 | 155,207 | Mother 3 #06: The Doorknob on the Way Out | 3:58:30 |
