| 1. |  CoxClips | 77,565 | Jesse Plays Potionomics | Part 2 | 2:03:27 |
| 2. | Michaela Laws | 59,255 | 『Michaela Plays』Potionomics - Finale | 47:35 |
| 3. | Quasimofo | 49,088 | Let's Play Potionomics (Blind) Part 24 FINALE - The Final Competition and Paying Off My Debt! | 48:47 |
| 4. | Nig Sparrow | 31,007 | Potionomics All BOSSES No Damage | 35:25 |
| 5. |  Weaver | 28,960 | Potionomics Playthrough Part 42 (end) | 34:22 |
| 6. | Pinstar | 20,008 | Pinstar Plays Potionomics: The Finale! | 1:00:23 |
| 7. | XSEEDgames | 5,569 | Potionomics: Masterwork Edition - Announcement Trailer | 1:10 |
| 8. |  Vagrant | 5,210 | CLOSING TIME | Potionomics (Let's Play ENDING) | 1:11:26 |
| 9. | Felicia Day | 5,063 | Felicia Day plays Potionomics! Part 1! #sponsored | 2:57:32 |
| 10. |  The Lost Chevalier | 4,696 | 【POTIONOMICS】Grand Finale!!! | 1:30:38 |
| 11. |  Churneo | 989 | ¡ES LA ELEGIDA PARA HACER POCIONES! :) | POTIONOMICS #1 | Gameplay Español | 13:31 |
| 12. |  Sch4f3r | 909 | Potionomics - Ending | 42:56 |
| 13. |  HistoryDoggo | 525 | Potionomics Playthrough - #35 - TOPPLING THE LEGEND!! *END* | 1:00:32 |
| 14. | SybilznBitz | 524 | Potionomics [Let's Play] Ep 12 "We Embrace Our Inner Gentleman Squirrel. Boss Finn Has No Hope." | 1:34:53 |
| 15. | MadRadIan | 507 | Potionomics #39: The Final Haggle! | 32:11 |
| 16. | ETA MediaGroup | 469 | Potionomics [028 - Haggle With The Best of 'Em] ETA Plays! | 15:54 |
| 17. | Allshouse Gaming | 363 | Let's Play Potionomics Part 49 Birds of a Feather | 36:33 |
| 18. | TheSharplyDressedMan | 355 | Potionomics - FULL PLAYTHROUGH 1440p - Part 8 and Finale | 3:02:24 |
| 19. | Cyber BB | 342 | CyberBB Plays Potionomics - Part 41 - Final Fight (Robin) | 28:25 |
| 20. | Indie Game Lover | 253 | Manage Potions & Deck-build for Gains | Potionomics | First Look Indie Game | 23:18 |
| 21. | aulddragon | 208 | Potionomics — Part 49 - Helping Xid With Her Writing | 33:09 |
| 22. | RPG Gamer VTuber- Mirai Tsukamu | 168 | Potionomics- There is a way to help Uncle? #7 [Spoilers Warning] | 4:04:28 |
| 23. |  CephalonKet | 154 | Let's Play POTIONOMICS | Part 4 | 2:09:27 |
| 24. | Games with Dialogue | 134 | Potionomics - Double Bubble, Toil And Troubles - Let's Play Ep. 7 | 1:04:44 |
| 25. | Gar1onriva | 128 | Third Contest | GV Potionomics #26 | 26:56 |
| 26. | Hiten Mitsuru VODs | 121 | Hiten Plays || Potionomics「Part 4」DROPPED | 1:13:49 |
| 27. | Nane Niwa Vods | 118 | VTuber Nane Niwa Let's Play Potionomics! [Episode 9] FINALE??? LETS BEAT THIS BOSS #WORMARMY | 2:26:54 |
| 28. | NanashiGaming96 | 101 | Let's Play - Potionomics | Winning the 1st Competition - Part 2.3 | 20:30 |
| 29. | Bun Keki | 88 | ★ POTIONOMICS ★ Guess who I want to Romance~ | 1:33:57 |
| 30. | RedxxEagle | 63 | Twitch Let's Play - Potionomics - Day 9 | 25:29 |
| 31. | SaveUrSoap | 58 | "Making MONEY" - Potionomics 37 (Let's Play) #vtuber | 21:21 |
| 32. | Wrath of Zalis | 53 | Run a Shop, Craft Potions, and Flirt with People - Let's Play Potionomics | 1:05:58 |
| 33. | noszellas | 51 | Time to pay off our bebt - Noszelias plays: Potionomics [Finale] | 3:06:06 |
| 34. | TemperamentalSage | 42 | Potionomics with TemperamentalSage - Day 6 (Completed) | 4:52:01 |
| 35. | Peter Moxilin | 37 | Let's Play Potionomics, Part 13 (Livestream 5/3) | 1:45:28 |
| 36. | TheKabooblesProject | 28 | TheKabooblesProject plays Potionomics: Episode 3 | 32:25 |
| 37. | Wristlocke | 25 | Potionomics first 10 days - Let's play part 1 | 3:53:55 |
| 38. | Headhunter Gaming | 25 | Hunter Plays: Potionomics | 54:23 |
| 39. |  Raziel Igor | 24 | Potionomics Demo Playthrough | 23:47 |
| 40. |  SupAndorea | 20 | Potionomics - Part 24 | 40:41 |
| 41. | QaizherOnline | 18 | Steam Next Fest | Potionomics Demo Gameplay Playthrough | Everything's Fine | 41:28 |
| 42. | Netty | 17 | THE CAT PIRATES! - Potionomics 【Part 16】 | 19:36 |
| 43. | Stoic | 12 | Potionomics | Let's Play Part 2 - New Day, New Plays | 28:10 |
| 44. | Sy Kusuri | 10 | Let's Play POTIONOMICS [Part 1] Sy Kusuri | 2:10:31 |
| 45. | Hesper's Quest | 8 | Lumi Plays Potionomics [Stream Archive Part 5] | 6:33:16 |
| 46. | Graynyte | 7 | Start of my Potionomics Playthrough! - Potionomics VOD 1 | 2:24:32 |
| 47. |  Egrill | 6 | Egrill plays Potionomics #09 (Day 41 - 45) | 2:37:59 |
| 48. | Kleiko | 4 | Potionomics Let's Play Part One | 2:00:01 |
| 49. |  AHrEJl💙💛 | 4 | Letsplay 💛💙Potionomics🔥 #1 | 3:08:04 |
| 50. | theballguy | 2 | Let's Play Potionomics Part 29 | 25:59 |
| 51. | Rydo | 0 | Potionomics New or Trending Game | 1:00 |
