Using Large-Scale Clinico-Genomics Data for in silico Clinical Trials and Precision Oncology

Channel:
United States Simons Institute for the Theory of Computing
Subscribers:
68,700
Published on ● Video Link: https://www.youtube.com/watch?v=RabfZpWSwZA


Category:
Vlog
Duration: 34:40
112 views
4

James Zou (Stanford University)
https://simons.berkeley.edu/talks/title-geometric-deep-learning-spatial-omics
From Algorithms to Discovery in Genome-Scale Biology and Medicine

I will discuss how to leverage large-scale EHR data linked with tumor mutation profiles to emulate cancer clinical trials in silico. This approach helps us to design real trials, making them more incluse and efficient (Liu et al. Nature 2021). It also helps to identify a large number of predictive biomarkers, i.e. mutations that impact the survival of patients who are taking specific chemo, targeted or immuno therapies (Liu et al. Nature Medicine 2022). These mutation-drug interactions are critical for treatment planning and precision oncology.



Other Videos By Simons Institute for the Theory of Computing


2022-07-11Distinct Gene Programs Underpinning ‘Disease Tolerance’ and ‘Resistance’ Against Infections
2022-07-11Determining the Molecular Intermediates Between Genotype and Phenotype
2022-07-11How Genome 3D Organization Regulates Alternative Splicing?
2022-07-11Predicting the Deleteriousness of Genomic Variants – Big and Small
2022-07-11Algorithms for Inferring Phenotypes from Ancient DNA
2022-07-11Mapping Biological Pathways Using Systematic Genetics and Cell Biology
2022-07-11Computational Approaches to Study Interactions Between Mutagenic Processes and Cellular Processes
2022-07-11A Tyrosine Kinase Protein Interaction Map Reveals Targetable EGFR Network Oncogenesis in Lung Cancer
2022-07-11A Binary Quantitative Interaction Mapping Approach: Elucidating Multiprotein Complexes in...
2022-07-11Long-Range Propagation of Genetic Effects in Molecular Networks
2022-07-11Using Large-Scale Clinico-Genomics Data for in silico Clinical Trials and Precision Oncology
2022-07-11A Statistical, Reference-Free Algorithm Subsumes Myriad Problems in Genome Science
2022-07-11Machine Learning for Single-Cell 3D Epigenomics
2022-07-11Understanding Molecular Complexity for Precision Medicine
2022-07-11Genomics of Cancer
2022-07-11Formatting Biological Big Data to Enable (Personalized) Systems Pharmacology
2022-07-11Landscapes of Human cis-regulatory Elements and Transcription Factor Binding Sites...
2022-07-11Spatial Transcriptomics Identifies Neighbourhoods and Molecular Markers of Alveolar Damage...
2022-07-11BANKSY: A Spatial Omics Algorithm that Unifies Cell Type Clustering and Tissue Domain Segmentation
2022-07-01Panel on Interpretability in the Law
2022-07-01Platform-supported Auditing Of Social Media Algorithms For Public Interest


Tags:
Simons Institute
theoretical computer science
UC Berkeley
Computer Science
Theory of Computation
Theory of Computing
From Algorithms to Discovery in Genome-Scale Biology and Medicine
James Zou