Top 100 The Binding of Isaac: Rebirth Videos With The Most Comments by LobosJrTop 100 » 200 » 300 » 400 » 500Video TitleCommentsCategoryGame1.Binding of Isaac: Rebirth - Killing Mega Satan (and Unlocking Dad's Key)71The Binding of Isaac: Rebirth 2.Isaac: Rebirth - Clearing Chest + Dark Room w/ the Lost!65The Binding of Isaac: Rebirth 3.The Binding of Isaac: Afterbirth | Dark Room + Delirium Victory Lap36The Binding of Isaac: Rebirth 4.Wild Card Wednesday (6/17/2016)31The Binding of Isaac: Rebirth 5.Binding of Isaac - Mom's Heart in 19:1831The Binding of Isaac: Rebirth Top 100 » 200 » 300 » 400 » 500