Top 100 The Binding of Isaac Videos With The Most Comments by Only IndiesTop 100 » 200 » 300 » 400 » 500Video TitleCommentsCategoryGame1.¡UN TOWER DEFENSE de The Binding of Isaac! (Plants vs Zombies + Isaac) • I.RULE85The Binding of Isaac 2.BOSSES: Ragdoll & Middle Horn • I.RULE42The Binding of Isaac 3.ASÍ ERA THE BINDING OF ISAAC HACE 10 AÑOS • Only Indies39The Binding of Isaac 4.Probando los CHALLENGES! Son ULTRA DIFÍCILES! 😱 • I.RULE22The Binding of Isaac 5.BOLA DE CRISTAL y D6 (¡Desbloqueamos los Challenges!) • I.RULE21The Binding of Isaac 6.RAINBOW BABY & PSYCHIC BABY • I.RULE14The Binding of Isaac 7.NUEVO PARCHE OFICIAL: REWORK DE LÁZARO Y MUCHOS CAMBIOS • Repentance0The Binding of Isaac 8.EL NUEVO REWORK DE LAZARUS ES UNA LOCURA • Repentance0The Binding of Isaac Top 100 » 200 » 300 » 400 » 500