| 2024-06-26 | Void Ink | 741 | Museum - Professor Layton and the Diabolical Box 100% Playthrough |19| Void Ink Plays | 31:34 |
| 2024-03-20 | Tykirou | 124 | Professor Layton and Pandora's Box (2009) | NDS | Full Playthrough - Part 7 | 5:41:26 |
| 2024-02-07 |  Aryashadeslay VA | 45,500 | The Culprit Revealed?!: Professor Layton and the Diabolical Box (Streamed February 1st, 2024) | 2:28:26 |
| 2023-09-28 |  Gamer UA | 1,160 | Professor Layton Pandora's Box HD port gameplay on Sony PS Vita Slim Playstation Vita 3.65 Henkaku | 10:54 |
| 2023-04-05 | Save Data | 76,500 | BEST OF Professor Layton and the Diabolical Box with an Actual Professor! Save Data Team | 29:45 |
| 2023-04-03 |  Britanouille | 48 | PR. LAYTON ET LA BOÎTE DE PANDORE Ep.16 - Un final émouvant :'( - Let's Play FR | 1:25:13 |
| 2023-03-15 | Maestro_2099 les VOD | 97 | Let's play: Professeur Layton et la boîte de Pandore #1 | 3:32:54 |
| 2023-02-05 |  InstaSim | 402 | Professor Layton and the Pandora's Box Part 26 - THE CULPRIT UNCOVERED | 26:13 |
| 2022-12-23 | HexTree | 457 | Professor Layton and the Diabolical Box - Blind Let's Play - part 8 (finale) | 1:16:39 |
| 2022-10-24 | pizze fritte | 1,310 | Professor Layton and the Diabolical Box HD: Playthrough - Prologue | 21:38 |
| 2022-09-22 | Bmaster4114 | 175 | Let's Play Professor Layton and the Diabolical Box: We are Running for our Lives! Finale | 3:22:09 |
| 2022-09-07 | Matrik On Stage | 812 | Let's Play Professor Layton & the Diabolical Box #46 -Finale! [Blind] | 42:43 |
| 2022-05-23 |  Icestar | 184 | Professor Layton & Pandora Box (Diabolical Box) Let's Play #17 - Potential Vampire!?? | 14:16 |
| 2022-04-18 | skatemancory222 | 709 | Professor Layton & the Diabolical Box Casual Playthrough [Part 3 - FINALE] | 5:31:56 |
| 2021-11-15 | Gaming Jay | 6,890 | Professor Layton and the Diabolical Box (Nintendo DS) - Let's Play 1001 Games - Episode 648 | 1:14:07 |
| 2021-10-31 | Pudding Muffin | 453 | Professor Layton and the Diabolical Box [10] The Culprit, Revealed | 34:38 |
| 2021-08-04 |  NikoDunkel | 1,670 | DIE WAHRHEIT: SCHATULLE DER PANDORA | Let's Play Professor Layton und die Schatulle der Pandora #21 | 52:41 |
| 2021-03-22 | Mil'ceryse | 39 | (Rediff) Let's Play Professeur Layton et la boîte de Pandore (7) : La fin du jeu !? | 51:42 |
| 2021-01-20 |  illustuff | 113 | El profesor Layton y la caja de Pandora || NDS || Playthrough - Part 06 [Spanish/Castellano] | 2:31:03 |
| 2020-11-23 | GamingMagic13 | 38,700 | Professor Layton and the Diabolical Box - Finale | Chapter Seven | 42:55 |
| 2020-10-14 | SoulHunter96 | 3,570 | Help! I need somebody! | Professor Layton und die Schatulle der Pandora | Folge 029 [Stream] | 23:47 |
| 2020-10-09 |  fluojn | 1,060 | Let's Play eli pelataan: Professor Layton and Pandora's Box osa 9 FINAALI | 56:10 |
| 2020-07-07 | Linkonito TV | 55 | Let's Play Professeur Layton et la boite de pandore (DS) #2 | 9:00:41 |
| 2020-06-19 | Quentibus | 448 | LPQuentibus - Professeur Layton et la boîte de Pandore #12 [FINAL] | 56:17 |
| 2018-06-17 | ChallengeTime | 112,000 | Let's Play Professor Layton und die Schatulle der Pandora (Part 49 / ENDE): Diabolische Box! | 54:16 |
| 2017-05-18 | RanguGamer | 334,000 | LP Layton y La Caja de Pandora 10 Atrapados Juntos | 48:55 |
| 2016-12-05 | HellfireComms | 35,400 | Professor Layton and Pandora's Box playthrough [Part 1: The Elysian Box] | 25:54 |
| 2016-10-18 | TRASHTAZMANI | 154,000 | PROFESSOR LAYTON und die Schatulle der Pandora • #62 - Geschafft! | Let's Play | 31:12 |
| 2016-04-03 | PokeSantiTW | 1,510 | Let's Play: El Profesor Layton y La Caja de Pandora - PARTE 3 - Tom, el niño perdido | 24:24 |
| 2015-06-04 |  Raxby | 1,670 | Professor Layton and Pandora's Box — Part 27 — Escape | 21:49 |
| 2015-03-01 | Jeroro | 4,370 | LP Professeur Layton et la boite de Pandore Ep.1 Prologue | 26:39 |
| 2014-11-21 | Nyaasu / DieNyaa | 2,009 | Let's Play Professor Layton und die Schatulle der Pandora [Part 11] | 1:03:11 |
| 2014-09-22 | DjDraculea | 1,250 | Let's Play Professor Layton und die Schatulle der Pandora #070 | 11:09 |
| 2014-08-27 | Ferim | 1,980 | Professeur Layton et la Boîte de Pandore | Episode 10 [FIN] : L'enfant cachée | Let's Play | 53:25 |
| 2014-07-12 | TwilightShiek | 4,120 | Let's Play Professor Layton und die Schatulle der Pandora [German/100%] #83 [Bonus/Final] | 16:09 |
| 2013-12-09 | El canal de Gavi | 1,330,000 | Lets Play "Profesor Layton y la Caja de Pandora" Ep.1 | 35:52 |
| 2013-09-22 | TheMcBlob | 51 | Let's Play Professor Layton und die Schatulle der Pandora (Part 20) - dummer Köter - | 14:44 |
| 2012-10-22 | ItsmeJamesAJ | 1,030 | Let's Play Professor Layton and the Diabolical Box - Part 1 - Smells Fishy... | 15:04 |
| 2012-02-07 | Suraht | 4,380 | Let's Play Professor Layton and the Diabolical Box - Part 50 | 27:21 |
| 2011-06-28 | NRWBoy18 | 16,400 | Lets Play Together - Prof. Layton und die Schatulle der Pandora [Bonus-Teil 1] | 14:00 |
| 2010-05-04 | HellfirePlaythroughs | 18,300 | Professor Layton and the Diabolical Box playthrough [Part 59] | 6:47 |
| 2009-08-24 | NintenDaanNC | 21,100 | [NC US] Real People Plays Professor Layton Video 1 | 1:20 |
