Top 100 Let's Play Channels for The Binding of Isaac: Rebirth from with the Longest Total Duration

This list represents the top 100 YouTube let's play channels rankings from for The Binding of Isaac: Rebirth based on the longest total video duration across all videos on their channel. This only includes channels that have created let's play videos. Numbers are retrieved via the YouTube API and updated daily. Channels are also listed with their latest let's play for The Binding of Isaac: Rebirth uploaded to YouTube.