| 3 days ago |  Zora Yurasaki | Moving To Caduceus | Trauma Center: Second Opinion (Blind) | 4:15:11 | 6 |
| 6 days ago | leonmachar | Trauma Center: Second Opinion easy 1:24:36 | 1:27:30 | 1 |
| 2024-04-22 |  Leo K. | Trauma Center: Second Opinion [Easy] in 1:16:59 (Current WR) | 1:19:27 | 24 |
| 2024-04-16 | Chakra Zoo | Chakra Plays "Trauma Center: Second Opinion" (Wii) part 1 | 55:32 | 16 |
| 2024-04-14 | LevathiaN | Trauma Center: Second Opinion Easy in 1h21min47s | 1:24:07 | 6 |
| 2024-04-13 | Zora Yurasaki | Time To Be A "Doctor"! | Trauma Center: Second Opinion (Blind) | 3:15:10 | 23 |
| 2024-04-13 | Cosimo Quiche | TC: SO IL Speedrun: X-4 in 1:33.300 | 1:43 | 3 |
| 2024-04-13 | Cosimo Quiche | TC: SO IL Speedrun: 6-3 in 1:02.850 | 1:15 | 3 |
| 2024-04-13 | Cosimo Quiche | TC: SO IL Speedrun: 1-3 in 32.234 | 0:44 | 1 |
| 2024-04-13 | Cosimo Quiche | TC: SO IL Speedrun: 1-1 in 29.283 | 0:39 | 4 |
| 2024-04-08 | LevathiaN | Trauma Center: Second Opinion X Operations in 15min 24s | 15:33 | 9 |
| 2024-04-05 |  La Mesita Anacrónica | Hace poco jugué Trauma Center Second Opinion - #atlus #nintendo #remake | 1:00 | 7,516 |
| 2024-03-23 | Cyiatic | Trauma Center: Second Opinion Credits • 4K 60FPS • AI Upsale | 1:46 | 4 |
| 2024-03-20 | barxbeast speedruns | Trauma Center: Second Opinion [Easy] in 1:20:19 | 1:22:40 | 12 |
| 2024-03-16 | LevathiaN | Trauma Center: Second Opinion Easy in 1h 22min 10s | 1:25:20 | 11 |
| 2024-03-15 | Leo K. | TCSO IL Speedrun | X-5 in 2:28.350 | 2:34 | 13 |
| 2024-03-15 | Leo K. | TCSO IL Speedrun | X-2 in 1:49.200 | 1:54 | 18 |
| 2024-03-15 | Leo K. | TCSO IL Speedrun | Z-4 in 55.350 | 1:01 | 21 |
| 2024-03-15 | Leo K. | TCSO IL Speedrun | Z-3 in 48.717 | 0:53 | 8 |
| 2024-03-15 | Leo K. | TCSO IL Speedrun | Z-2 in 1:30.267 | 1:36 | 6 |
| 2024-03-15 | どくたーわい | Trauma Center Second Opinion（Xoperations）speedrun 15m17s カドゥケウスZ2つの超執刀RTA | 15:23 | 6 |
| 2024-03-14 | Leo K. | TCSO IL Speedrun | X-1 in 55.350 | 1:01 | 23 |
| 2024-03-12 | どくたーわい | Trauma Center Second Opinion（X Operations）speedrun 15m52s カドゥケウスZ2つの超執刀RTA | 16:07 | 14 |
| 2024-03-11 | LevathiaN | Trauma Center: Second Opinion 1-3 in 35.350s | 0:53 | 15 |
| 2024-03-11 | LevathiaN | Trauma Center: Second Opinion 1-1 in 29.617s | 0:50 | 11 |
| 2024-03-08 | LevathiaN | Trauma Center: Second Opinion Easy in 1h 24min 16s | 1:27:47 | 8 |
| 2024-03-03 |  RUSC | [RU] Trauma Center: Second Opinion [гонка, X Operations] - @Thurler vs @LeoKeidran | 22:24 | 2 |
| 2024-03-01 |  ゆっくり黄色 | 【Wii 】そうだ、私は◯◯だ・・・【カドゥケウスZ 2つの超執刀】 | 8:39:29 | 57 |
| 2024-02-29 | ゆっくり黄色 | 【Wii 】そうだ、私は◯◯だ・・・【カドゥケウスZ 2つの超執刀】 | 9:08:49 | 66 |
| 2024-02-28 | ゆっくり黄色 | 【Wii 】そうだ、私は◯◯だ・・・【カドゥケウスZ 2つの超執刀】 | 8:16:29 | 55 |
| 2024-02-27 | ゆっくり黄色 | 【Wii 】そうだ、私は◯◯だ・・・【カドゥケウスZ 2つの超執刀】 | 9:19:52 | 66 |
| 2024-02-17 | Cyiatic | AI Upscale • Trauma Center: Second Opinion Nintendo Wii Trailer • [1080p 60FPS] | 1:16 | 11 |
| 2024-02-11 | NEO Metal Streams | Trauma Center Second Opinion | Vamos a practicar medicina | #MetalChill | 3:35:50 | 154 |
| 2024-01-31 |  GerdiTwin | MY MAN GOT INFECTED AND WE ARE FAR FROM HOME | Trauma Center: Second Opinion [END] | 1:13:41 | 6 |
| 2024-01-24 | GerdiTwin | MEDICAL TERRORISM STRIKES!! CADUCEUS IN ACTION! | Trauma Center: Second Opinion 5 | 1:02:10 | 6 |
| 2024-01-18 | LevathiaN | Trauma Center: Second Opinion Easy in 1h 24min 27s | 1:27:50 | 21 |
| 2024-01-18 | GerdiTwin | OUR MENTOR IS DYING BUT NOT ON MY WATCH | Trauma Center: Second Opinion 4 | 52:59 | 9 |
| 2024-01-16 | GasMax | Lost my medical licence, now I carve monsters. | 3:43:04 | 15 |
| 2024-01-12 | GerdiTwin | OPERATING ON A BOMB?! | Trauma Center: Second Opinion 3 | 1:10:06 | 10 |
| 2024-01-12 |  TodoConNaty | Trauma Center Second Opinion - Despair. Soundtrack With anime visuals ✨ | 1:38 | 88 |
| 2024-01-11 | Altar of Gaming | Trauma Center™ Second Opinion Opening Movie Cinematic (4K UHD 60FPS) | 2:29 | 11 |
| 2024-01-07 | World of Longplays | Wii Longplay [094] Trauma Center: Second Opinion (US) | 6:46:36 | 2,588 |
| 2024-01-06 | Echo Sen | No Context Sen | Trauma Center Second Opinion | 2:54 | 393 |
| 2024-01-06 | Cosimo Quiche | TC: SO IL Speedrun: 5-2 in 4:08.216 | 4:18 | 3 |
| 2024-01-05 | TodoConNaty | Trauma Center Second Opinion - Savato. Soundtrack With anime visuals ✨ | 2:22 | 39 |
| 2024-01-04 | GerdiTwin | ALL THE MALPRACTICE SUITS AND I'M STILL OPERATING | Trauma Center: Second Opinion 2 | 1:03:24 | 9 |
| 2024-01-03 | Cosimo Quiche | Trauma Center: Second Opinion [Easy] in 1:21:00 | 1:23:35 | 45 |
| 2024-01-03 | SunnyUT | Trauma Center Second Opinion Any% Easy Speedrun in 1:48:38 [1:50:27 IGT] | 1:53:05 | 10 |
| 2024-01-03 | GerdiTwin | FIRST DAY AS A SURGEON ALMOST LOST MY MEDICAL LICENSE | Trauma Center: Second Opinion 1 | 44:45 | 15 |
| 2024-01-02 | SunnyUT | Trauma Center Second Opinion Any% Easy Speedrun in 1:56:44 [2:00:14 IGT] | 2:03:02 | 12 |
| 2024-01-02 |  ESA Speedrunning | Trauma Center Second Opinion [X Operations] by Thurler and LeoKeidran - #ESASummer23 | 22:18 | 1,445 |
| 2023-12-31 | ILLU | Trauma center 2nd opinion is funnier when you got no idea what your doing | 1:55 | 16 |
| 2023-12-31 | Mega | Cranberries | 2:13 | 10 |
| 2023-12-30 | Cosimo Quiche | TC: SO IL Speedrun: X-1 in 1:03.833 | 1:13 | 28 |
| 2023-12-30 | Cosimo Quiche | TC: SO IL Speedrun: Z-5 in 1:06.350 | 1:17 | 35 |
| 2023-12-30 | Cosimo Quiche | TC: SO IL Speedrun: Z-4 in 56.833 | 1:07 | 5 |
| 2023-12-30 | Cosimo Quiche | TC: SO IL Speedrun: Z-3 in 50.217 | 1:03 | 16 |
| 2023-12-30 | Cosimo Quiche | TC: SO IL Speedrun: Z-2 in 1:33.484 | 1:43 | 51 |
| 2023-12-20 | Cosimo Quiche | TC: SO IL Speedrun: 2-3 in 15.850 | 0:24 | 3 |
| 2023-12-20 | Cosimo Quiche | TC: SO IL Speedrun: 1-2 in 28.250 | 0:38 | 29 |
| 2023-12-20 | Cosimo Quiche | TC: SO IL Speedrun: 1-1 in 29.667 | 0:40 | 8 |
| 2023-12-20 | barxbeast speedruns | Trauma Center: Second Opinion [Easy] in 1:21:01 | 1:23:22 | 14 |
| 2023-12-16 | Cyiatic | AI Upscale • Trauma Center: Second Opinion Opening Intro • [4K 60FPS] | 1:35 | 104 |
| 2023-12-14 | LevathiaN | Trauma Center: Second Opinion Easy in 1h 26min 43s | 1:30:07 | 16 |
| 2023-12-12 | barxbeast speedruns | Trauma Center: Second Opinion [Normal] in 1:22:54 | 1:26:05 | 10 |
| 2023-12-12 | LevathiaN | Trauma Center: Second Opinion 1-2 in 30.133s | 0:48 | 15 |
| 2023-12-12 | LevathiaN | Trauma Center: Second Opinion 1-1 in 30.467s | 0:45 | 26 |
| 2023-12-08 | Project F20 | Trauma Center: Second Opinion (Wii) | 23:32 | 99 |
| 2023-12-07 | TodoConNaty | Trauma Center Second Opinion - Caduceus USA. Soundtrack With anime visuals ✨ | 3:05 | 26 |
| 2023-12-07 | StephenPlays | Trauma Center: Second Opinion | Extra Life 2023 #12 | 34:29 | 2,250 |
| 2023-12-05 | Skinny Kitty | Trauma Center Second Opinion | 58:46 | 1 |
| 2023-12-03 | LevathiaN | Trauma Center: Second Opinion 1-1 in 31.834s | 0:42 | 17 |
| 2023-12-03 | Skinny Kitty | Trauma Center Second Opinion | 27:56 | 3 |
| 2023-12-02 | Skinny Kitty | Trauma Center Second Opinion | 1:26:28 | 5 |
| 2023-12-01 | KKCYBER ch. | 〚TRAUMA CENTER SECOND OPINION〛🩹📡 FINAL FIGHT 🩺🩸 [ PART 5 ] | 1:10:47 | 69 |
| 2023-11-24 |  MrRobinhx | Fredagssnakkis #162 Spillexpo, Valorant, Las Vegas Grand Prix og Trauma Center Second Opinion | 48:27 | 79 |
| 2023-11-21 | Cosimo Quiche | Trauma Center: Second Opinion [Normal] in 1:24:38 | 1:27:01 | 12 |
| 2023-11-20 | LevathiaN | Trauma Center: Second Opinion 5-2 in 4min 18s 068ms | 4:37 | 9 |
| 2023-11-18 | LevathiaN | Trauma Center: Second Opinion X Operations in 17min 56s | 18:53 | 27 |
| 2023-11-16 | どくたーわい | カドゥケウスZ2つの超執刀（Trauma Center Second Opinion） Normal RTA 1h26m30s | 1:28:23 | 16 |
| 2023-11-13 | barxbeast speedruns | 6-6 IL Simulator | 0:20 | 21 |
| 2023-11-11 | Cosimo Quiche | TC: SO IL Speedrun: Z-4 in 58.216 | 1:08 | 6 |
| 2023-11-11 | Cosimo Quiche | TC: SO IL Speedrun: Z-2 in 1:34.166 | 1:44 | 8 |
| 2023-11-11 | Cosimo Quiche | TC: SO IL Speedrun: 5-2 in 4:11.667 | 4:21 | 5 |
| 2023-11-11 | Cosimo Quiche | TC: SO IL Speedrun: Z-3 in 52.000 | 1:05 | 2 |
| 2023-11-09 | barxbeast speedruns | Trauma Center: Second Opinion | X-2 in 1:53.500 | 2:03 | 3 |
| 2023-11-06 | KKCYBER ch. | 〚TRAUMA CENTER SECOND OPINION〛🩹📡 The Internet's CUTEST Surgeon~! 🩺🩸 [ PART 4 ] | 6:06:51 | 72 |
| 2023-11-04 | leonmachar | Trauma Center: Second opinion All XS in 3:40:34 | 3:41:07 | 9 |
| 2023-10-29 | leonmachar | Trauma center second opinion all operations 2:19:03 | 2:19:21 | 4 |
| 2023-10-29 | Leo K. | Trauma Center: Second Opinion [All XS] in 2:35:28 | 2:37:16 | 101 |
| 2023-10-28 | leonmachar | Trauma center: Second opinion normal 1:27:19 | 1:29:37 | 7 |
| 2023-10-27 | Cosimo Quiche | Trauma Center: Second Opinion [X Ops] in 16:19 | 17:01 | 19 |
| 2023-10-26 | Tevex | Trauma Center: Second Opinion ▪ Nintendo Wii ▪ Longplay ▪ 4K ▪ Parte Final | 2:47:46 | 12 |
| 2023-10-26 | Tevex | Trauma Center: Second Opinion ▪ Nintendo Wii ▪ Longplay ▪ 4K ▪ Parte 1 | 4:24:10 | 9 |
| 2023-10-25 | ESA Speedrunning | Trauma Center: Second Opinion [Any% (Normal)] by LeoKeidran - #ESASummer23 | 1:22:22 | 3,176 |
| 2023-10-24 | RetroJimmyX | Trauma Center: Second Opinion (Wii U) | 1:29:09 | 7 |
| 2023-10-15 | LevathiaN | Trauma Center: Second Opinion 5-2 in 4min 21s 866ms | 4:45 | 17 |
| 2023-10-14 | LevathiaN | Trauma Center: Second Opinion Easy in 1h 27min 18s | 1:30:16 | 10 |
| 2023-10-13 | barxbeast speedruns | Trauma Center: Second Opinion [Normal] in 1:24:24 | 1:26:45 | 15 |
| 2023-10-11 | barxbeast speedruns | certified deftera moment | 1:29 | 15 |
