All of the Regenerative Necromorphs are much taller than Isaac and possess two blade-like limbs similar to Slashers.
The only way to kill a Regenerator for good is to burn it completely into dust before it is able to regenerate, either with a large and powerful explosion that obliterates its target at once completely or having the Necromorph burn completely in constant fire, such as when a shuttle or ship fires its engines.
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