Nucleotides and amino acids are vital building blocks in biology, but although nature has mastered their synthesis and polymerisation, their synthesis under mild, prebiotically plausible and simple conditions, without activation,in the laboratory is challenging. In this context, the uncatalysed synthesis of nucleosides and nucleotides from their precursors has been widely investigated. For instance, Orgel and co-workers synthesised small amounts of adenosine and guanosine nucleosides in separate reactions via the dehydration reaction of ribose together with the corresponding purine base, adenine or guanine, in the presence of inorganic polyphosphate salts. They also showed that nucleoside yields were improved by the addition of salts to the reaction solution, which canhelp drive dehydration reactions. However, the synthesis of canonical pyrimidine cytosine, thymine and uracil nucleosides is difficult and they have not been synthesized directly from the base and ribose. 📲 PW App Link - https://bit.ly/YTAI_PWAP 🌐 PW Website - https://www.pw.live/
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