Read the given paragraph and select the option that correctly fills the blanks in it. Hormones p...

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Read the given paragraph and select the option that correctly fills the blanks in it.
Hormones produce their effect on target tissue by binding to specific \( \mathbf{A} \) called hormone receptors located in the target tissues only. Water soluble hormones usually need \( \mathbf{B} \) receptor that generate C messenger for regulating cellular metabolism D soluble hormones can pass through cell membrane. The hormone which interact with \( \mathbf{E} \) receptor and mostly regulate gene expression or chromosome function by interaction of hormone - receptor complex with the genome.
\begin{tabular}{|c|c|c|c|c|c|}
\hline & A & B & C & D & E \\
\hline\( (1) \) & Proteins & Membrane bound & Second & lipid & Intra cellular \\
\hline\( (2) \) & Lipids & Membrane & Second & Water & Intra cellular \\
\hline\( (3) \) & Proteins & Intra cellular & second & lipid & extra cellular \\
\hline\( (4) \) & Proteins & membrane bound & primary & lipid & intra cellular \\
\hline
\end{tabular}
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