What is the minimum number of base substitutions required to change the nucleotide sequence of t...

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What is the minimum number of base substitutions required to change the nucleotide sequence of the \( \mathrm{HbA} \) (normal) allele to the \( \mathrm{HbS} \) (sickle cell) allele?
(a) 1
(b) 2
(c) 3
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