| 301. | This Item leads to PURE CHAOS | The Binding of Isaac: Repentance | 1,381 | | The Binding of Isaac: Rebirth
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| 302. | Absolutely Broken Kamikaze Combo | The Binding of Isaac: Repentance | 1,380 | | The Binding of Isaac: Rebirth
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| 303. | The "1 Heart" Greedier Run I've Been Dreading... | The Binding of Isaac: Repentance | 1,379 | | The Binding of Isaac: Rebirth
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| 304. | Average Streamer Run | The Binding of Isaac: Repentance | 1,376 | | The Binding of Isaac: Rebirth
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| 305. | Twisted Toxicity | The Binding of Isaac: Repentance | 1,376 | | The Binding of Isaac: Rebirth
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| 306. | I got handed this SPEEDRUN BUILD so I just went with it | The Binding of Isaac: Repentance | 1,371 | | The Binding of Isaac: Rebirth
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| 307. | Chocolate QUAD SHOT is NUTS | The Binding of Isaac: Repentance | 1,371 | | The Binding of Isaac: Rebirth
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| 308. | Pulling the Tearspam together | The Binding of Isaac: Repentance | 1,370 | | The Binding of Isaac: Rebirth
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| 309. | What could have been | The Binding of Isaac: Repentance | 1,370 | | The Binding of Isaac: Rebirth
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| 310. | Multipliers and Proptosis still GO HARD | The Binding of Isaac: Repentance | 1,368 | | The Binding of Isaac: Rebirth
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| 311. | Gelatine | The Binding of Isaac: Repentance | 1,368 | | The Binding of Isaac: Rebirth
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| 312. | Soy Milk Start to DELIRIUM | The Binding of Isaac: Repentance | 1,365 | | The Binding of Isaac: Rebirth
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| 313. | My Favourite Color of BRIMSTONE | The Binding of Isaac: Repentance | 1,365 | | The Binding of Isaac: Rebirth
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| 314. | Can Dr. Fetus get me through this MOTHER RUN? | The Binding of Isaac: Repentance | 1,364 | | The Binding of Isaac: Rebirth
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| 315. | Homing Split Shots are INCREDIBLE | The Binding of Isaac: Repentance | 1,363 | | The Binding of Isaac: Rebirth
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| 316. | Prism is my favourite TEAR SPAM item! | The Binding of Isaac: Repentance | 1,363 | | The Binding of Isaac: Rebirth
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| 317. | Stacks on Stacks | The Binding of Isaac: Repentance | 1,361 | | The Binding of Isaac: Rebirth
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| 318. | Collateral Damage | The Binding of Isaac: Repentance | 1,361 | | The Binding of Isaac: Rebirth
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| 319. | Very speyecy build | The Binding of Isaac: Repentance | 1,360 | | The Binding of Isaac: Rebirth
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| 320. | A Cat and his Succubus | The Binding of Isaac: Repentance | 1,360 | | The Binding of Isaac: Rebirth
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| 321. | Any day with PRISM is a good day | 1,360 | | The Binding of Isaac: Rebirth
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| 322. | Rings of DAMAGE | 1,359 | | The Binding of Isaac: Rebirth
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| 323. | The Carpal Tunnel Item | The Binding of Isaac: Repentance | 1,358 | | The Binding of Isaac: Rebirth
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| 324. | Underrated Items that DESTROY Bosses | The Binding of Isaac: Repentance | 1,358 | | The Binding of Isaac: Rebirth
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| 325. | Cat Warrior | The Binding of Isaac: Repentance | 1,355 | | The Binding of Isaac: Rebirth
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| 326. | Speedrunner's Dream Build | The Binding of Isaac: Repentance | 1,355 | | The Binding of Isaac: Rebirth
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| 327. | Raw Power | The Binding of Isaac: Repentance | 1,354 | | The Binding of Isaac: Rebirth
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| 328. | Just in Time | The Binding of Isaac: Repentance | 1,352 | | The Binding of Isaac: Rebirth
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| 329. | Satan Subscription | The Binding of Isaac: Repentance | 1,351 | | The Binding of Isaac: Rebirth
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| 330. | Wiggly Scythes | The Binding of Isaac: Repentance | 1,347 | | The Binding of Isaac: Rebirth
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| 331. | I made some QUESTIONABLE choices in this one | The Binding of Isaac: Repentance | 1,346 | | The Binding of Isaac: Rebirth
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| 332. | This Item Makes Death's List SO EASY | The Binding of Isaac: Repentance | 1,345 | | The Binding of Isaac: Rebirth
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| 333. | Ghost Pepper is HOT | The Binding of Isaac: Repentance | 1,345 | | The Binding of Isaac: Rebirth
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| 334. | This Challenge was seriously difficult... | Binding of Isaac Custom Challenges | 1,344 | | The Binding of Isaac: Rebirth
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| 335. | This Synergy looks SO GOOD | The Binding of Isaac: Repentance | 1,342 | | The Binding of Isaac: Rebirth
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| 336. | Rare Combo | The Binding of Isaac: Repentance | 1,339 | | The Binding of Isaac: Rebirth
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| 337. | Unintentional Speedrun | The Binding of Isaac: Repentance | 1,337 | | The Binding of Isaac: Rebirth
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| 338. | Underrated Beast Slayer! | The Binding of Isaac: Repentance | 1,337 | | The Binding of Isaac: Rebirth
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| 339. | Bunch of Favourites | The Binding of Isaac: Repentance | 1,335 | | The Binding of Isaac: Rebirth
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| 340. | Radioactive Circle | The Binding of Isaac: Repentance | 1,335 | | The Binding of Isaac: Rebirth
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| 341. | Haemo Brim at Home | The Binding of Isaac: Repentance | 1,332 | | The Binding of Isaac: Rebirth
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| 342. | Kings of UTILITY | The Binding of Isaac: Repentance | 1,329 | | The Binding of Isaac: Rebirth
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| 343. | "Splashing" on Mega Satan | The Binding of Isaac: Repentance | 1,329 | | The Binding of Isaac: Rebirth
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| 344. | DESTROY BOSSES with this Combo! | The Binding of Isaac: Repentance | 1,328 | | The Binding of Isaac: Rebirth
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| 345. | I found all of the BEST BOX SYNERGIES | The Binding of Isaac: Repentance | 1,328 | | The Binding of Isaac: Rebirth
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| 346. | The CLUTCHEST Contagion! | The Binding of Isaac: Repentance #shorts | 1,328 | | The Binding of Isaac: Rebirth
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| 347. | Run so good the RED STEW never runs out | The Binding of Isaac: Repentance | 1,326 | | The Binding of Isaac: Rebirth
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| 348. | This used to CRASH the game | The Binding of Isaac: Repentance | 1,324 | | The Binding of Isaac: Rebirth
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| 349. | Giant | The Binding of Isaac: Repentance | 1,324 | | The Binding of Isaac: Rebirth
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| 350. | Don't get too close to me | The Binding of Isaac: Repentance | 1,323 | | The Binding of Isaac: Rebirth
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| 351. | One Hit | The Binding of Isaac: Repentance | 1,323 | | The Binding of Isaac: Rebirth
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| 352. | Everyone gets an Aura! | 1,322 | | The Binding of Isaac: Rebirth
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| 353. | Is this the SUPERIOR HEART for Greedier? | The Binding of Isaac: Repentance | 1,322 | | The Binding of Isaac: Rebirth
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| 354. | I tried out BUFFED MARS so you don't have to | The Binding of Isaac: Repentance | 1,319 | | The Binding of Isaac: Rebirth
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| 355. | Ketchup Ring | The Binding of Isaac: Repentance | 1,315 | | The Binding of Isaac: Rebirth
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| 356. | FOUR Times the STEW | The Binding of Isaac: Repentance | 1,315 | | The Binding of Isaac: Rebirth
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| 357. | Black Ring of DESTRUCTION | The Binding of Isaac: Repentance | 1,315 | | The Binding of Isaac: Rebirth
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| 358. | I brought my Pet Spiders | The Binding of Isaac: Repentance | 1,313 | | The Binding of Isaac: Rebirth
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| 359. | The Floor 1 Win | The Binding of Isaac: Repentance | 1,312 | | The Binding of Isaac: Rebirth
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| 360. | I was short on Time and the Game HEARD ME | The Binding of Isaac: Repentance | 1,312 | | The Binding of Isaac: Rebirth
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| 361. | MISSILE BOMBS require some good Defenses | The Binding of Isaac: Repentance | 1,311 | | The Binding of Isaac: Rebirth
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| 362. | Angelic Brimflection | The Binding of Isaac: Repentance | 1,311 | | The Binding of Isaac: Rebirth
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| 363. | "This is not a Vanishing Twin run..." | The Binding of Isaac: Repentance | 1,309 | | The Binding of Isaac: Rebirth
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| 364. | Dream Build | The Binding of Isaac: Repentance | 1,308 | | The Binding of Isaac: Rebirth
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| 365. | I tried out BUFFED ABYSS so you don't have to | The Binding of Isaac: Repentance | 1,305 | | The Binding of Isaac: Rebirth
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| 366. | My FAVOURITE Angel Item loves HOMING | The Binding of Isaac: Repentance | 1,303 | | The Binding of Isaac: Rebirth
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| 367. | Bargain | The Binding of Isaac: Repentance | 1,302 | | The Binding of Isaac: Rebirth
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| 368. | Rollercoaster | The Binding of Isaac: Repentance | 1,300 | | The Binding of Isaac: Rebirth
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| 369. | Just Add Damage | The Binding of Isaac: Repentance | 1,298 | | The Binding of Isaac: Rebirth
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| 370. | Ultimate Saturnus | The Binding of Isaac: Repentance | 1,298 | | The Binding of Isaac: Rebirth
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| 371. | Treasure Hunter | The Binding of Isaac: Repentance | 1,296 | | The Binding of Isaac: Rebirth
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| 372. | I took LIBRA and it was kinda GREAT | The Binding of Isaac: Repentance | 1,293 | | The Binding of Isaac: Rebirth
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| 373. | The Cat and the Combo | The Binding of Isaac: Repentance | 1,289 | | The Binding of Isaac: Rebirth
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| 374. | This run was just RIDICULOUS | The Binding of Isaac: Repentance | 1,288 | | The Binding of Isaac: Rebirth
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| 375. | Adding some Lasers to my Lasers | 1,288 | | The Binding of Isaac: Rebirth
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| 376. | "Luck Down" | The Binding of Isaac: Repentance | 1,281 | | The Binding of Isaac: Rebirth
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| 377. | Double the Triple | The Binding of Isaac: Repentance | 1,278 | | The Binding of Isaac: Rebirth
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| 378. | Maybe I shouldn't | The Binding of Isaac: Repentance | 1,277 | | The Binding of Isaac: Rebirth
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| 379. | PROPTOSIS is the best and worst Item at the same time | The Binding of Isaac: Repentance | 1,273 | | The Binding of Isaac: Rebirth
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| 380. | Cat goes Boom | The Binding of Isaac: Repentance | 1,270 | | The Binding of Isaac: Rebirth
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| 381. | Stats aren't everything | The Binding of Isaac: Repentance | 1,270 | | The Binding of Isaac: Rebirth
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| 382. | How to win a run in 28 seconds | The Binding of Isaac: Repentance #shorts | 1,268 | Guide | The Binding of Isaac: Rebirth
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| 383. | Some Runs Just Have It All 5 | The Binding of Isaac: Repentance | 1,266 | | The Binding of Isaac: Rebirth
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| 384. | This Sword SAVED my Build and WRECKED my Hand | The Binding of Isaac: Repentance | 1,265 | | The Binding of Isaac: Rebirth
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| 385. | Not Mush Room For Improvement | The Binding of Isaac: Repentance | 1,265 | | The Binding of Isaac: Rebirth
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| 386. | I brought some Fetuses to MOTHER | The Binding of Isaac: Repentance | 1,264 | | The Binding of Isaac: Rebirth
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| 387. | Brimstone at Home | The Binding of Isaac: Repentance | 1,262 | | The Binding of Isaac: Rebirth
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| 388. | Filling the Room with TEARS | 1,262 | | The Binding of Isaac: Rebirth
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| 389. | Plop Goes the Kidney Stone | The Binding of Isaac: Repentance | 1,261 | | The Binding of Isaac: Rebirth
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| 390. | Everyone had to BAND TOGETHER to win this MOTHER run | The Binding of Isaac: Repentance | 1,261 | | The Binding of Isaac: Rebirth
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| 391. | When you keep finding great Items | The Binding of Isaac: Repentance | 1,260 | | The Binding of Isaac: Rebirth
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| 392. | Finally an OP Run again | The Binding of Isaac: Repentance | 1,260 | | The Binding of Isaac: Rebirth
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| 393. | This Combo is ABSURD | The Binding of Isaac: Repentance | 1,257 | | The Binding of Isaac: Rebirth
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| 394. | Do THIS to get the most out of your EARLY FLOORS! | The Binding of Isaac: Repentance | 1,255 | | The Binding of Isaac: Rebirth
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| 395. | Itsy Bitsy Tearspam | The Binding of Isaac: Repentance | 1,254 | | The Binding of Isaac: Rebirth
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| 396. | This DELIRIUM Run turned into a MOVIE | 1,254 | | The Binding of Isaac: Rebirth
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| 397. | Fastest BOSS RUSH Clear I've EVER Done | The Binding of Isaac: Repentance | 1,254 | | The Binding of Isaac: Rebirth
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| 398. | My FAVOURITE kind of Build | The Binding of Isaac: Repentance | 1,254 | | The Binding of Isaac: Rebirth
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| 399. | The CRAZIEST room drop | The Binding of Isaac: Repentance #shorts | 1,253 | | The Binding of Isaac: Rebirth
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| 400. | Tech X makes every build INSANE | The Binding of Isaac: Repentance | 1,252 | | The Binding of Isaac: Rebirth
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