| 301. | ??? | Blue Baby got BUFFED! Patch 1.7.8 | 104,461 | | The Binding of Isaac: Rebirth
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| 302. | Crazy SECRET Boss Fight! - The Reverie (Mod Showcase) | 101,612 | Show | The Binding of Isaac: Rebirth
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| 303. | INSANE Lazarus Rework! Great Character now! Patch 1.7.8 | 100,537 | | The Binding of Isaac: Rebirth
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| 304. | You can fully SKIP Satan's Leg Phase! (Repentance) | 100,094 | | The Binding of Isaac: Rebirth
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| 305. | Plum Flute - Item Guide - The Binding of Isaac: Repentance | 99,817 | Guide | The Binding of Isaac: Rebirth
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| 306. | Tech 2 Satisfactory! #tboi #isaac | 99,389 | | The Binding of Isaac: Rebirth
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| 307. | 4 More INSANE Planetarium Bosses!!! (Heaven's Call 2) | 99,257 | | The Binding of Isaac: Rebirth
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| 308. | The Scariest Isaac Room Ever... (Fiend Folio - The Sleeper) | 98,657 | | The Binding of Isaac: Rebirth
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| 309. | The Thunderclap! - Viewer Synergies #19 (SlayXc2) | 98,130 | | The Binding of Isaac: Rebirth
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| 310. | The Bubble Slasher! - Viewer Synergies #11 (SlayXc2) | 97,575 | | The Binding of Isaac: Rebirth
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| 311. | The 0.5% Death Theme Easter Egg In Fiend Folio! | 97,532 | | The Binding of Isaac: Rebirth
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| 312. | The Ninja (Naruto) Item Build! - The Binding of Isaac: Repentance | 97,282 | | The Binding of Isaac: Rebirth
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| 313. | All 21 UNLOCKS of Arachna Explained! (Mod Showcase) | 96,842 | Show | The Binding of Isaac: Rebirth
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| 314. | The Snowball Synergy! - Viewer Synergies #31 (SlayXc2) | 96,434 | | The Binding of Isaac: Rebirth
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| 315. | Playable Henry! Kind of... (Suplex Fusion Glitch Part 2!) | 96,158 | | The Binding of Isaac: Rebirth
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| 316. | Icky New Character! Arachna! (Isaac Mod Showcase) | 96,145 | Show | The Binding of Isaac: Rebirth
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| 317. | Psytosis! - Viewer Synergies #25 (SlayXc2) | 96,106 | | The Binding of Isaac: Rebirth
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| 318. | Cain's Other Eye COPIES You Now! (Repentance Patch 1.7.9) | 96,091 | | The Binding of Isaac: Rebirth
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| 319. | The Final 2 Giant Obstacles Are Here! | 95,788 | | The Binding of Isaac: Rebirth
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| 320. | These Enemies Literally Vent! Fiend Folio: The Dank Depths | 95,765 | | The Binding of Isaac: Rebirth
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| 321. | Mew Cat Coins! | 94,676 | | The Binding of Isaac: Rebirth
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| 322. | This 3 Item Glitch Synergy ONE-SHOTS everything! | 94,664 | | The Binding of Isaac: Rebirth
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| 323. | Greedier Bosses! Showcase of ALL Boss Resprites! | 94,648 | Show | The Binding of Isaac: Rebirth
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| 324. | The New Athame is SO MUCH FUN!! (Repentance Patch 1.7.9) | 94,502 | | The Binding of Isaac: Rebirth
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| 325. | Risk's Reward - Psionic Reroll! (Fiend Folio) | 94,226 | | The Binding of Isaac: Rebirth
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| 326. | 2 Item Break for Infinite Angel Items! (NO SCHOOLBAG!) - The Binding of Isaac Repentance | 94,012 | | The Binding of Isaac: Rebirth
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| 327. | Range Is Actually BAD For Monstro's Lung! Here Is Why! | 93,845 | | The Binding of Isaac: Rebirth
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| 328. | The Holy Flower! - Viewer Synergies #16 (SlayXc2) | 93,549 | | The Binding of Isaac: Rebirth
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| 329. | 18 NEW Custom Epic Fetus Synergies! | 93,482 | | The Binding of Isaac: Rebirth
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| 330. | Brimstone from Base to 120 Tears! (Isaac Tips n' Trivia) | 93,418 | | The Binding of Isaac: Rebirth
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| 331. | Knockout Technology! - Viewer Synergies #5 (SlayXc2) | 93,304 | Vlog | The Binding of Isaac: Rebirth
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| 332. | The Cthulhu Combo! - Viewer Synergies #12 (SlayXc2) | 93,179 | | The Binding of Isaac: Rebirth
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| 333. | The Pig's Tail Brimstone! - Viewer Synergies #21 (SlayXc2) | 93,091 | | The Binding of Isaac: Rebirth
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| 334. | This Cool New Beggar Will F*** You Up! (Brawler Beggar) | 91,588 | | The Binding of Isaac: Rebirth
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| 335. | Echo Chamber STILL breaks the game! (Repentance Patch 1.7.7) | 90,941 | | The Binding of Isaac: Rebirth
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| 336. | All NEW Bertran Synergies in Repentance! (Mod) | 90,839 | | The Binding of Isaac: Rebirth
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| 337. | What If The 7 Sins Had Champion Forms? (Improved & Reworked Foes) | 90,642 | | The Binding of Isaac: Rebirth
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| 338. | Infinite Damage Stacking with Dark Arts/Tainted Judas! | 90,345 | | The Binding of Isaac: Rebirth
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| 339. | Pills in Repentance - What is New? What Has Changed? | 89,977 | | The Binding of Isaac: Rebirth
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| 340. | Use this Void Glitch for extra Stats! (Repentance) | 89,878 | | The Binding of Isaac: Rebirth
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| 341. | This Item Turns Isaac Into A Dice! - Isaac'D's Eulogy (Fiend Folio) | 89,259 | Vlog | The Binding of Isaac: Rebirth
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| 342. | Henry VS Pee-Wee! (Boss Showcase) | 89,041 | Show | The Binding of Isaac: Rebirth
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| 343. | This is what the D7 does to The Beast! (Isaac Repentance) | 88,847 | | The Binding of Isaac: Rebirth
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| 344. | TAINTED Arachna Explained - Big Spider Familiars! (Mod Showcase) | 88,111 | Show | The Binding of Isaac: Rebirth
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| 345. | Death Certificate Is STILL BROKEN In Patch 1.7.9a!!! | 87,869 | | The Binding of Isaac: Rebirth
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| 346. | Adoption Papers - Trinket Guide - The Binding of Isaac: Repentance | 87,862 | Guide | The Binding of Isaac: Rebirth
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| 347. | Uranus + Death's List - Cool Utility Synergy in Repentance! | 87,520 | | The Binding of Isaac: Rebirth
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| 348. | The Cellar - FULL Fiend Folio Enemy Showcase! | 87,309 | Show | The Binding of Isaac: Rebirth
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| 349. | Only Pick 2 Of Them, NEVER All 3! (Isaac Anti-Synergy) | 87,303 | | The Binding of Isaac: Rebirth
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| 350. | Become A Poop Bender! - Viewer Synergies #14 (SlayXc2) | 87,257 | | The Binding of Isaac: Rebirth
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| 351. | Breath Of Life Got NEW Book Synergies!!! (Patch 1.7.9a) | 87,131 | | The Binding of Isaac: Rebirth
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| 352. | You can Break Jacob & Esau with ONE Item! (Friend Finder + J&E) | 86,874 | | The Binding of Isaac: Rebirth
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| 353. | Jupiter - Item Guide - The Binding of Isaac: Repentance | 86,749 | Guide | The Binding of Isaac: Rebirth
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| 354. | All Boss Champions - Fiend Folio Mod - The Binding of Isaac Afterbirth+ | 86,666 | | The Binding of Isaac: Rebirth
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| 355. | Cool NEW Item Pool Discs!!! (Fiend Folio) | 86,030 | | The Binding of Isaac: Rebirth
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| 356. | NEW BOSS - Gutso The Great! (Mod Showcase) | 85,514 | | The Binding of Isaac: Rebirth
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| 357. | All 14 Unlocks of Tainted Andromeda! (Mod Showcase) | 85,188 | Show | The Binding of Isaac: Rebirth
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| 358. | Antibirth Enemies Are Back! - Restored Monsters Pack Showcase | 84,992 | Show | The Binding of Isaac: Rebirth
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| 359. | NEW Boss! Gibs, The Gelatinous Cube! (Mod Jam 2023) | 84,543 | | The Binding of Isaac: Rebirth
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| 360. | Lil Clot - Trinket Guide - The Binding of Isaac: Repentance | 84,228 | Guide | The Binding of Isaac: Rebirth
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| 361. | Tainted Judas's Birthright was changed! (Repentance Patch 1.7.6) | 84,193 | | The Binding of Isaac: Rebirth
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| 362. | Tainted Diesaac - The walking Game Break! (Mod Showcase) | 83,380 | Show | The Binding of Isaac: Rebirth
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| 363. | Death Certificate... With A Twist! - Error's Crazy Slots (Fiend Folio) | 82,678 | | The Binding of Isaac: Rebirth
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| 364. | The Most Important Buff In Patch 1.7.9! Change My Mind :D | 82,373 | | The Binding of Isaac: Rebirth
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| 365. | Tarnished Cain Synergy Teaser - Holy Hand Grenade! | 82,294 | | The Binding of Isaac: Rebirth
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| 366. | All 21 Online Co-op Sins In Repentance+ Explained! | 81,977 | | The Binding of Isaac: Rebirth
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| 367. | TAINTED Deleted - Character Showcase (Mod) - Isaac Repentance | 81,954 | | The Binding of Isaac: Rebirth
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| 368. | ALL Tomb Bosses And Mini-Bosses! (Isaac Revelations | Repentance) | 80,168 | | The Binding of Isaac: Rebirth
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| 369. | This Synergy makes Tainted Lazarus Immortal! | 80,020 | | The Binding of Isaac: Rebirth
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| 370. | How to play Isaac with your Mouse! | 79,702 | Guide | The Binding of Isaac: Rebirth
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| 371. | Fixed Boss Sprites and Changes in Patch 1.7.8a! (The Binding of Isaac Repentance) | 78,329 | | The Binding of Isaac: Rebirth
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| 372. | Mega Mush - Item Guide - The Binding of Isaac: Repentance | 78,258 | Guide | The Binding of Isaac: Rebirth
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| 373. | Which Tear is in the Air the longest? Isaac Range Contest! | 77,832 | | The Binding of Isaac: Rebirth
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| 374. | Is the Shell Game Rigged? (Isaac Myth Busted) | 77,631 | | The Binding of Isaac: Rebirth
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| 375. | Cursed Penny - Trinket Guide - The Binding of Isaac: Repentance | 77,589 | Guide | The Binding of Isaac: Rebirth
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| 376. | Tainted Forgotten has no Speed Limit?!? (Bug) | 77,572 | | The Binding of Isaac: Rebirth
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| 377. | I Found The Longest Piece Of Crap In Isaac! | 77,474 | | The Binding of Isaac: Rebirth
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| 378. | Sacred Lightning! - Viewer Synergies #22 (SlayXc2) | 76,675 | | The Binding of Isaac: Rebirth
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| 379. | Tooth And Nail Can Grant You A Free Win!!! | 76,474 | | The Binding of Isaac: Rebirth
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| 380. | 35 NEW Custom Pony Dash Synergies! | 76,400 | | The Binding of Isaac: Rebirth
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| 381. | Strange Key - Trinket Guide - The Binding of Isaac: Repentance | 75,728 | Guide | The Binding of Isaac: Rebirth
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| 382. | Notched Axe is a Powerhouse on Bethany! | 75,364 | | The Binding of Isaac: Rebirth
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| 383. | THE VOID AND DELIRIUM REWORKS ARE FINALLY HERE!!! [April Fools] | 74,900 | | The Binding of Isaac: Rebirth
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| 384. | This Boss is THICC - "The Moon" Boss Showcase (Mod) | 74,871 | Show | The Binding of Isaac: Rebirth
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| 385. | Electric Snot! - Viewer Synergies #24 (SlayXc2) | 74,668 | | The Binding of Isaac: Rebirth
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| 386. | Trash Cow Item! - Become Back your Money! (Mod) | 74,607 | | The Binding of Isaac: Rebirth
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| 387. | Anal... WHAT Now?!? All Unlocks Of Tarnished Blue Baby Explained! | 74,281 | | The Binding of Isaac: Rebirth
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| 388. | Get infinite exploding Babies with this C Section Synergy! | 73,336 | | The Binding of Isaac: Rebirth
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| 389. | Built-in Active Items on Regular Characters! - Mod Showcase (Repentance) | 73,266 | Show | The Binding of Isaac: Rebirth
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| 390. | They Made a Wordle For The Binding Of Isaac!!! | 72,266 | | The Binding of Isaac: Rebirth
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| 391. | Isaac Goes Rock Star!!! - Ridiculous Metal (Fiend Folio) | 72,236 | | The Binding of Isaac: Rebirth
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| 392. | Tech.5 Got A Stealth Buff In Repentance+ !!! (It's Whacky) | 72,190 | | The Binding of Isaac: Rebirth
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| 393. | Lil Abaddon - Item Guide - The Binding of Isaac: Repentance | 72,161 | Guide | The Binding of Isaac: Rebirth
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| 394. | Fiend Character Guide - Fiend Folio Mod - The Binding of Isaac Afterbirth+ | 72,112 | Guide | The Binding of Isaac: Rebirth
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| 395. | Spirit Sword Slaughter Satisfactory! #tboi | 72,061 | | The Binding of Isaac: Rebirth
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| 396. | These BUFFED Items Synergize With Each Other! (Athame + My Shadow) | 71,221 | | The Binding of Isaac: Rebirth
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| 397. | 4.5 Volt - Item Guide - The Binding of Isaac: Repentance | 70,559 | Guide | The Binding of Isaac: Rebirth
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| 398. | ALL Deathmatch Minigames In Isaac Co-op! (Repentance+) | 69,251 | | The Binding of Isaac: Rebirth
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| 399. | Temporary Tattoo - Trinket Guide - The Binding of Isaac: Repentance | 68,464 | Guide | The Binding of Isaac: Rebirth
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| 400. | This Bethany Synergy Will Crash Your Game 100% | 68,372 | | The Binding of Isaac: Rebirth
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