Top 100 The Binding of Isaac Videos With The Most Comments by MycromatorTop 100 » 200 » 300 » 400 » 500Video TitleCommentsCategoryGame1.Ruining the binding of Isaac8The Binding of Isaac 2.(edited) Does the OG Isaac hold up in 2025? (...kinda yeah actually!)0The Binding of Isaac 3.Don't ask why but I'm playing flash Isaac in 2025 (livestream)0The Binding of Isaac 4.Does flash Isaac hold up in 2025?0The Binding of Isaac Top 100 » 200 » 300 » 400 » 500