Top 100 The Binding of Isaac Videos With The Most Comments by MrSmegheneghanTop 100 » 200 » 300 » 400 » 500Video TitleCommentsCategoryGame1.The Binding of Isaac: Greed - Extended to 1 Hour406The Binding of Isaac 2.Binding of Isaac - Lord of the Flies5The Binding of Isaac 3.The Streaming of Isaac - Horrible Chest Pains4The Binding of Isaac 4.Binding of Isaac - Nine Deaths3The Binding of Isaac 5.Binding of Isaac Infomercial - A Little Thing About Little Steve2The Binding of Isaac 6.Binding of Isaac - Stupid Fly Edition2The Binding of Isaac 7.Binding of Isaac - The Doctor's Revenge!2The Binding of Isaac 8.Binding of Isaac: Wrath of the Lamb - Large Marge!2The Binding of Isaac 9.Binding of Isaac: Wrath of the Lamb - The Purist Poundland Special!2The Binding of Isaac 10.Binding of Isaac - Persistent Explosions Bug2The Binding of Isaac 11.Binding of Isaac - The Horrible Play Edition!2The Binding of Isaac 12.Binding of Isaac - Max's Head2The Binding of Isaac 13.Binding of Isaac - Best Recorded Run Edition!1The Binding of Isaac 14.Binding of Isaac - "Meat 4 Evar!" With Added Challenge and Commentary!1The Binding of Isaac 15.Binding of Isaac: Wrath of the Lamb - Tonberry Style!1The Binding of Isaac 16.Binding of Isaac - Blue Baby Edition!1The Binding of Isaac 17.Binding of Isaac - Epic Brimstone1The Binding of Isaac 18.Binding of Isaac - Spider Boy!1The Binding of Isaac 19.Binding of Isaac: Wrath of the Lamb - Attempting to be Pure0The Binding of Isaac 20.Binding of Isaac: Wrath of the Lamb - Door Bindings Failed?0The Binding of Isaac 21.Binding of Isaac: Wrath of the Lamb - Aborted Dark Was The Night Attempt0The Binding of Isaac 22.Binding of Isaac - Roasting of Satan0The Binding of Isaac 23.Binding of Isaac: Wrath of the Lamb - Isaac Was Sorta Good Today0The Binding of Isaac 24.Binding of Isaac: Wrath of the Lamb - Gee Mother****ing Gee0The Binding of Isaac 25.Binding of Isaac: Wrath of the Lamb - Isaac Was Good Today!0The Binding of Isaac 26.Binding of Isaac: Wrath of the Lamb - 7 Years Bad Luck?0The Binding of Isaac 27.Binding of Isaac: Wrath of the Lamb - Dark Was The Night!0The Binding of Isaac Top 100 » 200 » 300 » 400 » 500