| 401. | This Isaac Challenge Made Me Cry | 19:35 | | The Binding of Isaac: Rebirth
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| 402. | Unlocking Confessionals | 19:34 | | The Binding of Isaac: Rebirth
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| 403. | ALWAYS Take Chaos | 19:33 | |
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| 404. | What Happens If Isaac Gets INFINITE Quad Shots? | 19:32 | | The Binding of Isaac: Rebirth
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| 405. | Disappointing Update News | 19:32 | | The Binding of Isaac: Rebirth
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| 406. | Incredibly Satisfying Shot | 19:31 | | The Binding of Isaac: Rebirth
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| 407. | How I Got Every Dollar Imaginable | 19:30 | | The Binding of Isaac: Rebirth
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| 408. | This New Isaac Ending Is CRAZY | 19:28 | | The Binding of Isaac: Rebirth
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| 409. | This Was A TERRIBLE Mistake | 19:26 | | The Binding of Isaac: Rebirth
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| 410. | This Eden Start Was SO SATISFYING | 19:25 | | The Binding of Isaac: Rebirth
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| 411. | Rock Bottom Be Like: | 19:25 | | The Binding of Isaac: Rebirth
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| 412. | This Floor Gave Me EVERY Quality 4 Item | 19:23 | | The Binding of Isaac: Rebirth
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| 413. | This Is Why I LOVE Rerolling: | 19:23 | | The Binding of Isaac: Rebirth
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| 414. | This Is The Most Satisfying Synergy EVER | 19:22 | | The Binding of Isaac: Rebirth
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| 415. | Keeper, but He's WAY Harder Now | 19:21 | | The Binding of Isaac: Rebirth
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| 416. | The Most INSANE Synergy In the Game: | 19:20 | | The Binding of Isaac: Rebirth
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| 417. | Frog Moment 🐸 | 19:17 | | The Binding of Isaac: Rebirth
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| 418. | I Played With These Isaac Youtubers. it was a mistake. | 19:16 | | The Binding of Isaac: Rebirth
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| 419. | Tainted Mattman Is Good and Real | 19:15 | | The Binding of Isaac: Rebirth
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| 420. | Damocles Moment | 19:14 | | The Binding of Isaac: Rebirth
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| 421. | The Rock Bottom Experience: | 19:13 | | The Binding of Isaac: Rebirth
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| 422. | How I Unlocked Tarnished Lost | 19:13 | | The Binding of Isaac: Rebirth
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| 423. | Is THIS My Worst Synergy Ever? | 19:12 | | The Binding of Isaac: Rebirth
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| 424. | Least Broken Repentance Shop: | 19:12 | | The Binding of Isaac: Rebirth
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| 425. | How I rigged EVERY FLOOR In Repentance | 19:11 | | The Binding of Isaac: Rebirth
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| 426. | The NEW Character Is Cursed | 19:11 | | The Binding of Isaac: Rebirth
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| 427. | Most Fragile Character EVER | 19:08 | | The Binding of Isaac: Rebirth
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| 428. | The Fastest Dice of ALL TIME | 19:07 | | The Binding of Isaac: Rebirth
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| 429. | What Infinite Damage ACTUALLY Looks Like: | 19:05 | | The Binding of Isaac: Rebirth
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| 430. | Rock Bottom Moment | 19:04 | | The Binding of Isaac: Rebirth
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| 431. | Eden's Blessing Moment | 19:04 | | The Binding of Isaac: Rebirth
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| 432. | Tarnished Samson Is CRAZY | 19:04 | | The Binding of Isaac: Rebirth
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| 433. | This is my RISKIEST run yet | 19:02 | | The Binding of Isaac: Rebirth
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| 434. | 1000+ TEARS PER SECOND | 18:59 | | The Binding of Isaac: Rebirth
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| 435. | Proof That Dead God Makes You Luckier: | 18:57 | | The Binding of Isaac: Rebirth
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| 436. | This NEW Sacred Orb Is Amazing | 18:56 | | The Binding of Isaac: Rebirth
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| 437. | How I Unlocked Tainted Eve | 18:50 | | The Binding of Isaac: Rebirth
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| 438. | Unlocking Godhead | 18:50 | | The Binding of Isaac: Rebirth
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| 439. | When Your FIRST Item Is Glitched Crown: | 18:49 | | The Binding of Isaac: Rebirth
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| 440. | DON'T Play Isaac while high... | 18:46 | | The Binding of Isaac: Rebirth
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| 441. | This First Floor is PERFECT | 18:46 | | The Binding of Isaac: Rebirth
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| 442. | IMPOSSIBLE Luck | 18:46 | | The Binding of Isaac: Rebirth
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| 443. | 100% Risk, 0% Reward | 18:44 | | The Binding of Isaac: Rebirth
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| 444. | The NEW Death Certificate Is Cursed | 18:43 | | The Binding of Isaac: Rebirth
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| 445. | The NEW Apollyon Rework is Incredible | 18:42 | | The Binding of Isaac: Rebirth
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| 446. | I've NEVER Made A Bigger Mistake... | 18:38 | | The Binding of Isaac: Rebirth
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| 447. | How I Got GODHEAD in 2.74 Seconds | 18:38 | | The Binding of Isaac: Rebirth
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| 448. | The LUCKIEST Brimstone You've Ever Seen | 18:36 | | The Binding of Isaac: Rebirth
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| 449. | I Achieved the Sacred Orb SPEEDRUN World Record | 18:35 | | The Binding of Isaac: Rebirth
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| 450. | I Played The Most BASED Repentance Character | 18:34 | | The Binding of Isaac: Rebirth
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| 451. | Most Satisfying Deal | 18:32 | | The Binding of Isaac: Rebirth
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| 452. | I Discovered the RAREST Room In Repentance | 18:31 | | The Binding of Isaac: Rebirth
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| 453. | I Discovered How to Buy INFINITE Items... | 18:30 | Guide | The Binding of Isaac: Rebirth
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| 454. | So They BUFFED Dataminer... It was a mistake. | 18:28 | | The Binding of Isaac: Rebirth
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| 455. | I STARTED with INFINITE Items | 18:27 | | The Binding of Isaac: Rebirth
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| 456. | Most Satisfying Shot | 18:25 | | The Binding of Isaac: Rebirth
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| 457. | This is What PEAK Isaac Looks Like: | 18:25 | | The Binding of Isaac: Rebirth
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| 458. | What Starting with GLITCHED CROWN Looks Like | 18:23 | | The Binding of Isaac: Rebirth
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| 459. | Restarting Gave Me THIS | 18:23 | | The Binding of Isaac: Rebirth
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| 460. | Most Satisfying Luck | 18:23 | | The Binding of Isaac: Rebirth
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| 461. | Why I ALWAYS Take Sacred Orb | 18:23 | | The Binding of Isaac: Rebirth
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| 462. | I Got The C Section SPEEDRUN World Record | 18:21 | | The Binding of Isaac: Rebirth
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| 463. | BIGGEST Mistake In Isaac History: | 18:21 | | The Binding of Isaac: Rebirth
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| 464. | Incredibly Satisfying Synergies | 18:20 | | The Binding of Isaac: Rebirth
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| 465. | This Synergy Is EASILY the Most Satisfying | 18:19 | | The Binding of Isaac: Rebirth
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| 466. | How I Got TOO STRONG In Isaac | 18:17 | | The Binding of Isaac: Rebirth
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| 467. | Tainted Forgotten.exe | 18:16 | | The Binding of Isaac: Rebirth
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| 468. | The Luckiest I've EVER Been: | 18:14 | | The Binding of Isaac: Rebirth
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| 469. | UNIMAGINABLE Luck | 18:14 | | The Binding of Isaac: Rebirth
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| 470. | Most Damage Possible? | 18:13 | | The Binding of Isaac: Rebirth
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| 471. | I Started With the CRAZIEST Luck Possible | 18:13 | | The Binding of Isaac: Rebirth
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| 472. | They Added A NEW Rock Bottom | 18:12 | | The Binding of Isaac: Rebirth
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| 473. | How I Unlocked Tarnished Cain | 18:12 | | The Binding of Isaac: Rebirth
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| 474. | This Synergy WILL Satisfy You | 18:12 | | The Binding of Isaac: Rebirth
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| 475. | My LUCKIEST Start Ever | 18:11 | | The Binding of Isaac: Rebirth
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| 476. | How I Unlocked the Lost | 18:09 | | The Binding of Isaac: Rebirth
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| 477. | This Character Has A LITERAL Dog | 18:08 | | The Binding of Isaac: Rebirth
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| 478. | how it feels to play tainted lost in Repentance | 18:08 | | The Binding of Isaac: Rebirth
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| 479. | Unlocking Tainted Judas | 18:07 | | The Binding of Isaac: Rebirth
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| 480. | They Added FLASH Isaac to Repentance!! | 18:06 | | The Binding of Isaac: Rebirth
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| 481. | This NEW Character Is A Fever Dream | 18:05 | | The Binding of Isaac: Rebirth
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| 482. | Double the Tears, Double the Damage | 18:05 | | The Binding of Isaac: Rebirth
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| 483. | How is This Possible?? | 18:03 | | The Binding of Isaac: Rebirth
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| 484. | The LUCKIEST Crawlspace EVER | 18:02 | | The Binding of Isaac: Rebirth
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| 485. | I've Never Had THIS Luck | 18:02 | | The Binding of Isaac: Rebirth
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| 486. | This Destroys EVERY Boss in ONE Frame | 18:01 | | The Binding of Isaac: Rebirth
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| 487. | This OBLITERATED My Computer | 18:01 | | The Binding of Isaac: Rebirth
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| 488. | This NEW Dice Broke My Game | 18:01 | | The Binding of Isaac: Rebirth
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| 489. | This is BAD... | 18:00 | | The Binding of Isaac: Rebirth
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| 490. | This Isaac Challenge Is FREAKY | 18:00 | | The Binding of Isaac: Rebirth
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| 491. | This Dice COMPLETELY Breaks The Game: | 17:58 | | The Binding of Isaac: Rebirth
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| 492. | How I Unlocked Tainted Apollyon | 17:58 | | The Binding of Isaac: Rebirth
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| 493. | When the First Floor Gives You THIS | 17:58 | | The Binding of Isaac: Rebirth
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| 494. | Unlocking Mega Blast | 17:57 | | The Binding of Isaac: Rebirth
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| 495. | They Added The GOLDEN PAN To The Game!! | 17:56 | | The Binding of Isaac: Rebirth
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| 496. | Why I ALWAYS Check My Secret Room | 17:56 | | The Binding of Isaac: Rebirth
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| 497. | How ONE Button Press INSTANTLY Broke My Game: | 17:55 | | The Binding of Isaac: Rebirth
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| 498. | Secret Rooms In Repentance Be Like: | 17:54 | | The Binding of Isaac: Rebirth
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| 499. | Repentance's NEW Best Item in the Game: | 17:49 | | The Binding of Isaac: Rebirth
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| 500. | This Eden Start Is INSANE | 17:49 | | The Binding of Isaac: Rebirth
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