| 401. | Golden Balls Moment | 164,336 | | The Binding of Isaac: Rebirth
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| 402. | They Added THIS to Repentance?? | 164,113 | | The Binding of Isaac: Rebirth
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| 403. | This First Floor Had Insane Luck | 164,107 | | The Binding of Isaac: Rebirth
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| 404. | The NEW Apollyon Rework is Incredible | 164,080 | | The Binding of Isaac: Rebirth
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| 405. | The CHEAPEST Free Win I've Ever Seen | 163,991 | | The Binding of Isaac: Rebirth
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| 406. | The HARDEST Character I've Ever Played: | 163,787 | | The Binding of Isaac: Rebirth
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| 407. | Big Isaac Changes | 163,671 | | The Binding of Isaac: Rebirth
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| 408. | Luckiest Isaac synergy on earth | 163,593 | | The Binding of Isaac: Rebirth
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| 409. | Eden Runs Be Like: | 163,403 | | The Binding of Isaac: Rebirth
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| 410. | The CRAZIEST Restart In Isaac History | 163,153 | | The Binding of Isaac: Rebirth
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| 411. | This ACTUALLY Finally Happened | 162,985 | | The Binding of Isaac: Rebirth
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| 412. | This Synergy Will Destroy YOUR PC | 162,938 | | The Binding of Isaac: Rebirth
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| 413. | This NEW Item Gave Me Unlimited Tears | 162,486 | | The Binding of Isaac: Rebirth
|
| 414. | How to INSTANTLY Get Rock Bottom | 162,435 | Guide | The Binding of Isaac: Rebirth
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| 415. | Isaac, But I Have to CLICK the Enemies | 162,392 | | The Binding of Isaac: Rebirth
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| 416. | Why I ALWAYS Take Sacred Orb | 162,382 | | The Binding of Isaac: Rebirth
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| 417. | This Destroys EVERY Boss in ONE Frame | 162,360 | | The Binding of Isaac: Rebirth
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| 418. | How I Unlocked Tarnished Lost | 162,273 | | The Binding of Isaac: Rebirth
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| 419. | The Run Was Rigged From The Start | 162,228 | | The Binding of Isaac: Rebirth
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| 420. | This Dice COMPLETELY Breaks The Game: | 162,222 | | The Binding of Isaac: Rebirth
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| 421. | The Most DANGEROUS Start Possible... | 162,203 | | The Binding of Isaac: Rebirth
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| 422. | How I Unlocked Tainted Jacob | 162,189 | | The Binding of Isaac: Rebirth
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| 423. | Mentally Unhinged Isaac (Ft. NotAlbino) | 161,913 | | The Binding of Isaac: Rebirth
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| 424. | They Added A NEW Tech Item. It's Incredible. | 161,749 | | The Binding of Isaac: Rebirth
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| 425. | Tainted Lost Be Like: | 161,749 | | The Binding of Isaac: Rebirth
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| 426. | Least Lucky Mattman Run: | 161,655 | | The Binding of Isaac: Rebirth
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| 427. | What Getting Every Quality 4 Item Looks Like | 161,571 | | The Binding of Isaac: Rebirth
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| 428. | I Found The PERFECT Reroll | 161,547 | | The Binding of Isaac: Rebirth
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| 429. | The Most SATISFYING Character Ever: | 161,420 | | The Binding of Isaac: Rebirth
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| 430. | This Crane Game Gave Me EVERYTHING | 161,002 | | The Binding of Isaac: Rebirth
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| 431. | Playable Siren Is INCREDIBLE | 160,947 | | The Binding of Isaac: Rebirth
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| 432. | I GOT THE NEW ISAAC ACHIEVEMENT!! | 160,909 | | The Binding of Isaac: Rebirth
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| 433. | Absurdly Rigged Synergies | 160,882 | | The Binding of Isaac: Rebirth
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| 434. | How Is This Luck Even Possible? | 160,870 | | The Binding of Isaac: Rebirth
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| 435. | Repentance+ DLC but my teammates are unironically high | 160,592 | | The Binding of Isaac: Rebirth
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| 436. | This Character Has The MAXIMUM Damage Multiplier: | 160,568 | | The Binding of Isaac: Rebirth
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| 437. | Least Powerful Modded Character | 160,515 | | The Binding of Isaac: Rebirth
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| 438. | The Legend Of Strawman | 160,487 | | The Binding of Isaac: Rebirth
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| 439. | The New Ghost Pepper Rework Is INSANE | 160,463 | | The Binding of Isaac: Rebirth
|
| 440. | What INFINITE Luck Looks Like | 160,408 | | The Binding of Isaac: Rebirth
|
| 441. | This New Final Boss And Ending Were Simply Amazing | 160,225 | | The Binding of Isaac: Rebirth
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| 442. | Tainted Delirium Is INSANELY Difficult | 160,158 | | The Binding of Isaac: Rebirth
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| 443. | This First Floor Was SO Satisfying | 159,763 | | The Binding of Isaac: Rebirth
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| 444. | LUCKIEST Secret Room Possible | 159,748 | | The Binding of Isaac: Rebirth
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| 445. | How I Unlocked Birthright | 159,706 | | The Binding of Isaac: Rebirth
|
| 446. | Disappointing Update News | 159,567 | | The Binding of Isaac: Rebirth
|
| 447. | I Found The Most SATISFYING Synergy | 159,474 | | The Binding of Isaac: Rebirth
|
| 448. | Isaac Modding Has Changed FOREVER!! | 159,385 | | The Binding of Isaac: Rebirth
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| 449. | This Start Was A Mistake | 159,142 | | The Binding of Isaac: Rebirth
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| 450. | How I Dominated Delirium with Tainted Lost in Repentance | 159,089 | | The Binding of Isaac: Rebirth
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| 451. | The Most SATISFYING Tarnished Keeper | 158,975 | | The Binding of Isaac: Rebirth
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| 452. | This First Floor Had The CRAZIEST Luck: | 158,896 | | The Binding of Isaac: Rebirth
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| 453. | The NEW Character Is Cursed | 158,684 | | The Binding of Isaac: Rebirth
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| 454. | This is What DEAD GOD Luck Looks Like: | 158,423 | | The Binding of Isaac: Rebirth
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| 455. | The GREATEST Isaac Tournament EVER | 158,404 | | The Binding of Isaac: Rebirth
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| 456. | This Shop has the BEST Items: | 158,359 | | The Binding of Isaac: Rebirth
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| 457. | This is PERFECTION | 158,040 | | The Binding of Isaac: Rebirth
|
| 458. | This New Dice Has INFINITE Possibilities | 157,799 | | The Binding of Isaac: Rebirth
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| 459. | The New Isaac Update is HUGE (Repentance v.1.9.7) | 157,782 | Vlog | The Binding of Isaac: Rebirth
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| 460. | I Found The RAREST Room In Isaac | 157,665 | | The Binding of Isaac: Rebirth
|
| 461. | Huge Isaac Update | 157,245 | Vlog | The Binding of Isaac: Rebirth
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| 462. | I Achieved the Cricket's Head SPEEDRUN World Record | 157,223 | | The Binding of Isaac: Rebirth
|
| 463. | I Gave Isaac 64 Death Certificates. This Was The Result | 157,181 | | The Binding of Isaac: Rebirth
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| 464. | When I accidentally get too lucky | 157,164 | | The Binding of Isaac: Rebirth
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| 465. | I Will NEVER Have This Luck Again | 157,154 | | The Binding of Isaac: Rebirth
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| 466. | This New Character BREAKS Time and Space: | 157,123 | | The Binding of Isaac: Rebirth
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| 467. | The NEW Delirious Meta DESTROYS Everything! | 157,117 | | The Binding of Isaac: Rebirth
|
| 468. | I've NEVER Had This Luck Before | 156,896 | | The Binding of Isaac: Rebirth
|
| 469. | I Gulped EVERY Trinket in Isaac. It was a mistake. | 156,667 | Let's Play | The Binding of Isaac: Rebirth
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| 470. | Isaac's NEW Difficulty Is Completely: | 156,355 | | The Binding of Isaac: Rebirth
|
| 471. | Most Satisfying Luck | 156,322 | | The Binding of Isaac: Rebirth
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| 472. | Craziest First Floor | 156,273 | | The Binding of Isaac: Rebirth
|
| 473. | The New Tech Item Is INSANE | 156,224 | | The Binding of Isaac: Rebirth
|
| 474. | These New Hearts Give You INFINITE Stats | 156,182 | | The Binding of Isaac: Rebirth
|
| 475. | They Added A NEW Playable Boss, He's Amazing | 156,111 | | The Binding of Isaac: Rebirth
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| 476. | Tainted Keeper Be LIke: | 156,069 | | The Binding of Isaac: Rebirth
|
| 477. | This Dice Gives The RAREST Items: | 156,018 | | The Binding of Isaac: Rebirth
|
| 478. | The Most SATISFYING Start Of All Time | 155,918 | | The Binding of Isaac: Rebirth
|
| 479. | The Most SATISFYING Synergy I've Ever Found | 155,858 | | The Binding of Isaac: Rebirth
|
| 480. | How I Beat Delirium Without Moving | 155,768 | | The Binding of Isaac: Rebirth
|
| 481. | I Time Traveled Through 10 Timelines to Get This Brimstone | 155,508 | | The Binding of Isaac: Rebirth
|
| 482. | I Abused INFINITE Rerolls | 155,387 | | The Binding of Isaac: Rebirth
|
| 483. | These NEW Apollyon Buffs Are Crazy | 155,271 | | The Binding of Isaac: Rebirth
|
| 484. | The 1 In 1,000,000 Synergy | 155,237 | | The Binding of Isaac: Rebirth
|
| 485. | 1000+ TEARS PER SECOND | 155,212 | | The Binding of Isaac: Rebirth
|
| 486. | We Tried Adding RTX Technology To Isaac | 155,114 | | The Binding of Isaac: Rebirth
|
| 487. | This Is WAY Too Satisfying | 154,499 | | The Binding of Isaac: Rebirth
|
| 488. | Incredibly Satisfying Shot | 154,243 | | The Binding of Isaac: Rebirth
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| 489. | THE 10,000+ DAMAGE SHOT | 154,218 | | The Binding of Isaac: Rebirth
|
| 490. | New Most Difficult Character Just Dropped | 153,940 | | The Binding of Isaac: Rebirth
|
| 491. | This New Item Gives You INFINITE Tears | 153,933 | | The Binding of Isaac: Rebirth
|
| 492. | The New R Key Is ACTUALLY Broken | 153,768 | | The Binding of Isaac: Rebirth
|
| 493. | The LUCKIEST Eden Start Of The Year? | 153,730 | | The Binding of Isaac: Rebirth
|
| 494. | The Sword That INSTANTLY Broke My Game | 153,695 | | The Binding of Isaac: Rebirth
|
| 495. | Most BASED Lilith Run: | 153,665 | | The Binding of Isaac: Rebirth
|
| 496. | We Added Rock Bottom 2. It's INSANE. | 153,467 | | The Binding of Isaac: Rebirth
|
| 497. | I Achieved the Death Certificate SPEEDRUN World Record | 153,459 | | The Binding of Isaac: Rebirth
|
| 498. | How I BOUGHT Infinite TEARS | 153,361 | | The Binding of Isaac: Rebirth
|
| 499. | When You Have DEAD GOD You Get Runs Like These | 153,188 | | The Binding of Isaac: Rebirth
|
| 500. | 0% Skill, 100% Luck | 153,107 | | The Binding of Isaac: Rebirth
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