| 1. |  PlayMaster ✮VARIEDAD&DIFERENCIA✮ | 32,183 | Alien Syndrome - PSP - Gameplay / Review - Un Extraño Remake | 14:50 |
| 2. |  NintendoComplete | 20,492 | Alien Syndrome (NES) Playthrough - NintendoComplete | 28:11 |
| 3. | TheGwardian | 9,988 | Let's Play Alien Syndrome PSP [Part 1] - Aileen Harding | 1:09:52 |
| 4. | IndieGamerRetro | 7,242 | Let's Play ~ Alien Syndrome, No Damage/No Death [Part 6] | 11:28 |
| 5. | Media Pool | 3,258 | Alien Syndrome (NES) Playthrough Longplay Retro game | 18:40 |
| 6. |  Satoshi Matrix | 1,483 | PlayStation 2 Classics 023 - Alien Syndrome [Sega Ages] | 12:28 |
| 7. | IGN | 1,154 | Alien Syndrome PlayStation 2 Gameplay_2004_08_19_1 | 1:01 |
| 8. | Studio ManHot | 728 | Let's play #36 Old game in MS-DOS - Alien Syndrome | 4:55 |
| 9. |  Beyond The Scanlines | 642 | "Alien Syndrome" on Commodore 64 - Rob Plays | 8:56 |
| 10. |  Kev Curtis Uncutize | 552 | Let's Play till Game Over Alien Syndrome MegaDrive (Deutsch/HD) | 6:26 |
| 11. | magmawk | 288 | Fantasy Zone and Alien Syndrome (Arcade / ps2 collection) LzQukPlays | 14:51 |
| 12. | PrinceWatercress | 281 | Let's Play Alien Syndrome (Game Gear) AGAIN, Part 5: Mother Alien | 5:37 |
| 13. | arklon22 | 246 | Lets Play Alien Syndrome #3: Tough end bosses! | 20:56 |
| 14. | Crow Continuum | 197 | LPT1K - Alien Syndrome (Master System) | 8:10 |
| 15. | The Fireorb Mod Museum | 192 | Rick and Morty NES • Full Play-through | 44:56 |
| 16. | Geeks and Nerds | 165 | Pablo Plays - Rick and Morty (NES) | 11:30 |
| 17. | Gaming Jay | 149 | Alien Syndrome (NES) - A Classic Sega Game on the NES - Saturday Afternoon Gaming | 39:43 |
| 18. | tarquinnff3 | 143 | Alien Syndrome - NES | 3:37 |
| 19. |  Al Games Review | 134 | Alien Syndrome - PlayStation Vita - PSP | 56:55 |
| 20. |  LowCostMachine | 121 | [PSP] Alien Syndrome 👽 - La Defensa de Seti-Alpha 4 🚀 | 1:56:20 |
| 21. | ZetaPlays | 112 | Alien Syndrome (NES) - Nightmare Fuel Walking Simulator | 29:44 |
| 22. | Mame Arcade Playthroughs | 107 | Alien Syndrome Arcade Playthrough | 15:37 |
| 23. | MEGADAN29 | 99 | Alien Syndrome NES Playthrough | 29:57 |
| 24. | Prospect | 91 | Alien Syndrome - Playthrough | No Commentary (NES) | 27:23 |
| 25. | ecmyersvids | 82 | NES Alphanumeric! #053: ALIEN SYNDROME (Tengen) + Mad City (Full Playthrough) | 1:29:27 |
| 26. |  Longplay Center | 75 | Alien Syndrome (Master System) Playthrough [4K] | 30:16 |
| 27. | dluxx7 | 65 | D.Lux plays: Alien Syndrome (1988/Sega Master System) Full playthrough | 32:50 |
| 28. | MrVenom1974 | 62 | Day 17 - Alien Syndrome | Sony Playstation Portable | 30 Days Challenge | #psp | 16:23 |
| 29. | Haidi Retro Gaming | 59 | Alien Syndrome / 4K Wii emulator Dolphin / RTX 2080ti | 11:13 |
| 30. |  Sayuki Gameplays | 52 | ¿Juego De Terror? Alien Syndrome NES Let's Play En Español | 29:37 |
| 31. |  MaeL | 38 | WedNESday Gaming - Alien Syndrome | 32:47 |
| 32. | Clainekun | 36 | Let's Play-Mini [Blind] 34 - Alien Syndrome | 5:36 |
| 33. | Retro Cheating :D | 34 | Alien Syndrome One Level Playthrough on Master System's Pro Action Replay :D | 8:06 |
| 34. | Piva Plays | 31 | Let's Play... Alien Syndrome!! | 15:11 |
| 35. | HeadDropProductions | 31 | Georg Mack Plays the Classics - Alien Syndrome (NES) | 2:23 |
| 36. |  Now Loading Please Wait | 31 | Sega Ages 2500 Series Vol 14 Alien Syndrome Japan - Playstation 2 (PS2) | 0:40 |
| 37. | GeekyAntics | 26 | #RetroFriday | #NES Alphabet Soup - 1942, 8 Eyes, Action 52, Dracula-Kun & Alien Syndrome | #Nintend | 1:43:42 |
| 38. | Sam Pae | 21 | Alien Syndrome (Arcade) - Playthrough | 14:26 |
| 39. | Ashgabat Cat | 19 | Let's Play Alien Syndrome | Arcade Calvacade | 20:49 |
| 40. | Total Geekgasm | 12 | Let's Play Everything: Alien Syndrome (SMS) | 8:20 |
| 41. | Narujess | 10 | Alien Syndrome Nes (let's play FR) | 42:11 |
| 42. | Punkinnonstop | 9 | Alien Syndrome NES | Episode 1 | Geodude | PunkinRePlays | 10:16 |
| 43. | Como Não Jogar! | 7 | explorando jogos Nes: After Burner,Air Fortnes, Air wolf,Alien Syndrome,Alpha Mission,Turbo Racing | 49:11 |
| 44. | Mongoose1Billion | 5 | Let's Play: Alien Syndrome | 5:55 |
| 45. |  4lexGrey | 4 | Alien Syndrome (NES) Playthrough | 17:11 |
| 46. |  Mr.RetroTekno | 3 | Alien Syndrome - Gameplay - PlayStation Portable | 23:07 |
