| 1. |  NintendoComplete | Tetris & Dr. Mario (SNES) Playthrough - NintendoComplete | 89 | Let's Play |
| 2. | StephenPlays | NES Classic #27 - Dr. Mario | 72 | Let's Play |
| 3. | NintendoComplete | Dr. Mario (NES) Playthrough - NintendoComplete | 70 | Let's Play |
| 4. | Erin Plays Extras | Halloween Stream from Hell (Operation board game and Dr. Mario) - Erin Plays Extras | 69 | Let's Play |
| 5. | Sculpted Nostalgia | Making THE VIRUSES with CLAY | Dr. Mario Sculpture | 61 | Let's Play |
| 6. | NintendoComplete | Dr. Mario (NES) Playthrough | 53 | Let's Play |
| 7. | IGN | Dr. Mario - IGN Plays | 35 | Let's Play |
| 8. | MadameWario | Let's Play Dr Mario #2 Hotter than a Fever | 35 | Let's Play |
| 9. | MadameWario | Let's Play Dr. Mario #5 Pain in the Butt | 27 | Let's Play |
| 10. | MadameWario | Let's Play Dr. Mario #6 Speedy Recovery | 24 | Let's Play |
| 11. | MadameWario | Let's Play Dr Mario #4 Goose Bumps | 22 | Let's Play |
| 12. | MadameWario | Let's Play Dr Mario #3 Allergic Reaction | 21 | Let's Play |
| 13. | GoldenFoxStream | GoldenFox Plays Dr. Mario | 20 | Let's Play |
| 14. | Heavy Metal Gamer Show | Heavy Metal Gamer Plays: Dr. Mario (NES) - Episode 1 | 18 | Let's Play |
| 15. | TopKirby8305 | TK's Lets Play: Dr.Mario (NES) | 18 | Let's Play |
| 16. | Let's Play With Brigands | Dr. Mario (NES) | 15 | Let's Play |
| 17. | MadameWario | Let's Play Dr Mario #7 The Pimp Pill | 14 | Let's Play |
| 18. | MarkyJoe | EvilEggoWaffle Plays Through Doctor Mario | 14 | Let's Play |
| 19. | MadameWario | Let's Play Dr. Mario #8 All Better! | 13 | Let's Play |
| 20. | OnlyLevelOne | Dr Mario - NES - Only Level One | 11 | Let's Play |
| 21. | Jay 117 | Sussy Mario | Dr. Mario's Lab.exe | 9 | Let's Play |
| 22. | Bossome | A MARIO HORROR GAME!! - Dr. Mario's Lab (Full Game Playthrough) | 9 | Let's Play |
| 23. | PugmanPlays | Dr Mario. Nes [Vs] (2 player) - Man vs Woman - Brit vs American Face off (Round 1) HD - PugmanPlays | 6 | Let's Play |
| 24. | 1upTV Games | Dr Mario - Taking the Red, Yellow and Blue Pill | 6 | Let's Play |
| 25. | CouchQuest Gaming | CouchQuest Plays Tetris & Dr Mario | 6 | Let's Play |
| 26. | LPMaster6 | Let's Play Tetris & Dr. Mario Part 3 (Multiplayer & Finale) | 5 | Let's Play |
| 27. | Lancer | Let's Play Dr. Mario - Part 2: Jagged Little Pill | 5 | Let's Play |
| 28. | LPMaster6 | Let's Play Tetris & Dr. Mario Part 1 | 5 | Let's Play |
| 29. | TheSuperLink95 | My Brother Plays: NES Online, Dr. Mario | 4 | Let's Play |
| 30. | Lancer | Let's Play Dr. Mario - Part 1: The Doctor is in | 4 | Let's Play |
| 31. | GiantGrotle | Stephen Plays: Dr. Mario (NES) | GiantGrotle | 4 | Let's Play |
| 32. | TheRealZ3ro | Let's Play - Dr. Mario (2 Players) - Part 2 [Unreleased LP from 2015] [Outtakes 14] | 4 | Let's Play |
| 33. | Omnine | NES Dr Mario Playthrough Ending Cuts | 4 | Let's Play |
| 34. | ballerscuba | Mistakes Pile Up - Dr. Mario Part 2 | 4 | Let's Play |
| 35. | Battle Geek Plus - Press Start To AWESOME! | Dr. Mario Let's Play (NES) - Battle Geek Plus: We Play Games! | 4 | Let's Play |
| 36. | mmorse1017 | ProtonJon Plays Dr. Mario While Masae Reads His Fanfiction | 4 | Let's Play |
| 37. | Jimmy A Gaming | Let's Play Dr. Mario/ NES/ Jimmy A Plays | 4 | Let's Play |
| 38. | Lancer | Let's Play Dr. Mario - Part 3: The Doctor is out | 3 | Let's Play |
| 39. | ballerscuba | Questionable Degree - Dr. Mario Part 1 | 3 | Let's Play |
| 40. | ZetaPlays | Tetris & Dr Mario (SNES) - I'm Not Good At Either | 3 | Let's Play |
| 41. | LPMaster6 | Let's Play Tetris & Dr. Mario Part 2 | 3 | Let's Play |
| 42. | TotalGore | Rodrick VS Jareth in DR. MARIO - PART 2 | 2 | Let's Play |
| 43. | TheRealZ3ro | Let's Play - Dr. Mario (2 Players) - Part 1 [Unreleased LP from 2015] [Outtakes 14] [700th Video] | 2 | Let's Play |
| 44. | LPMaster6 | Let's Play Dr. Mario Part 3 (Multiplayer) | 2 | Let's Play |
| 45. | Shinobi Salmon | CLUTCH Hooktail Battle! "Dr. Mario" Playthrough!! | 2 | Let's Play |
| 46. | Rain Crow The Game Ninja | LET'S PLAY SUM "DR.MARIO!" ON THE NINTENDO SWITCH ONLINE APP DOCKED MODE! | 1 | Let's Play |
| 47. | Video Games 101 | Dr. Mario (NES) | 4K 60FPS | Video Games 101 | 1 | Let's Play |
| 48. | jtomally9681's Gaming Channel | Let's Play #33 Dr. Mario for the NES (Verses Edition) | 1 | Let's Play |
| 49. | jtomally9681's Gaming Channel | Let's Play #116 Dr. Mario for the Game Boy | 1 | Let's Play |
| 50. | ExceedEdge_ | Dr. Mario Full Playthrough | 1 | Let's Play |
| 51. | Ultra C | Dr. Mario: More Like Mr. Malpractice - Ultra Competitive | 1 | Let's Play |
| 52. | The Fireorb Mod Museum | ROM Hack Museum | Dr. Boosette • Dr. Mario • Gameplay | 1 | Let's Play |
| 53. | MorleyQ | Morley Q. Plays Smash #79 - The Day of The Doctor | 1 | Let's Play |
| 54. | Average Man | An Average Update: Let's Play Dr. Mario | 1 | Let's Play |
