| 1. |  Maverick Hunter Daniel | 658,261 | MHD replies to the Assigned Male Webcomic | 49:09 |
| 2. | TheLegendofRenegade | 296,315 | Mega Man X6 - Rainy Turtloid Stage (Sega Genesis Remix) | 5:43 |
| 3. | Solibrae | 6,454 | Mega Man X6 Tweaks Mod/ROM Hack Showcase | 1:49:49 |
| 4. | KASH "The Megaman Pensioner" | 4,759 | The Wall Jump Animation Cancel | X Challenge & mega man x6 | 0:00 |
| 5. | FCPlaythroughs | 3,818 | Mega Man X6 playthrough [Extras 2: X's Ending] ~Finale~ | 28:48 |
| 6. | AstraVex | 1,783 | Mega Man X6 - Blaze Heatnix (Guitar Cover) | 2:30 |
| 7. | Mean SK Beatz | 1,491 | [SOLD]✶DOPE✶ Jeezy ✘ Yo Gotti Type Beat - "Mega Man X6 - Infinity Mijinion" | Type Beat 2020 ⁴ᴷ | 3:19 |
| 8. | Retro Pixel Lizard's Retro Game Dungeon | 1,351 | Ultimate Armor X VS High Max - Round 2 | 0:48 |
| 9. | Robotnikegg1990 | 1,202 | Megaman X6 Hell Sigma (Vaporwave) | 3:06 |
| 10. | VideoGameJNPoop | 426 | Rating Vs. Rating - The Complete Fifth Set: The Greatest Age Certificate Battle Ever!! | 23:55 |
| 11. | Stop Motion Gamer | 288 | Mega Man X6 - Final Part | 23:02 |
| 12. | Darkstar263 | 269 | Favourite Videogame Tunes 232: Infinity Mijinion - Megaman X6 | 2:28 |
| 13. | Retro Hawk | 212 | Mega Man X6 - Playstation 1 (PSX) (PS1 Mini Classic Gameplay) | 12:24 |
| 14. | GameDev.tv | 126 | 🔵ON THIS DAY: Mega Man X6 Graced the PlayStation 1 in Japan! 👾🎉 #shorts #megaman #ps1 #playstation1 | 0:11 |
| 15. | Octopimp Archive | 110 | Mega Man X6 [Session 2] [Final] (17/03/20) | 4:06:18 |
| 16. | gl1tchmast3r | 104 | Why is Mega Man X6 so hard!? | gl1tchmast3r on #Twitch | 0:28 |
| 17. | Dante Sparkson | 67 | Mega Man X6 - A Platform Crash | 0:55 |
| 18. | HYPERPEACE | 54 | Megaman X6 - Infinity Mijinion Stage Cover | 1:16 |
| 19. | RatchetGamingAllStars | 47 | Polymega Ps1 Rockman X6 Gameplay | 12:36 |
| 20. | Takeshino | 40 | The Failed 0.5 Stream, and "Great" Writing | Mega Man Marathon Game 16: Mega Man X6 - Stream 1 | 54:13 |
| 21. | Manc Pete | 31 | MEGA MAN X6 (PS1, 2001) | PART 1 | MANCPETE PLAYS | 0:00 |
| 22. | Sparkson Plays | 26 | Mega Man X6 - A Platform Crash | 0:55 |
| 23. | Funk Star | 23 | Mega Man X6 (PS1) | 2:53 |
| 24. | NLI Haru | 13 | Mega Man X6 | Session #3 | 1:44:04 |
| 25. | Through Retro Tinted Glasses | 5 | Title screen : Mega Man X6 : PS1 | 1:47 |
| 26. | Pikakid98 | 5 | (Game Beast) Mega Man X Legacy Collection 2 [Mega Man X6] - THIS IS JUST UNFAIR!! | 22:42 |
