| 1. |  Max Derrat | 63,310 | The Unparalleled Brilliance of Pathologic 2's Mythology | 17:28 |
| 2. | ramblelime | 43,886 | Pathologic 2 Is The Most Important Game Ever (To Me) | 15:36 |
| 3. | Егор Клёнов | 42,765 | Обзор главной российской игры года, или Мор во время чумы | 6:10 |
| 4. | Pat Stares At | 18,485 | Pat Stares At Pathologic 2! | 3:22:22 |
| 5. | Asamu KSV | 16,795 | Pathologic 2 - Utopia - Track 14 - Darkness (No Words) | 3:46 |
| 6. | imNoveria 🎮 | 6,720 | I'm Redy to Suffer Again (Not Really) | 0:00 |
| 7. | Glitchboss420 | 4,157 | Pathologic 2 | RTX 2060 6GB + i7-6700 + 16GB RAM | 21:44 |
| 8. | Luckless Lovelocks | 3,514 | Murder and Rumours - Pathologic 2 Part 2 - Pre-Release Luckless Looks At | 1:19:02 |
| 9. | Cannot be Tamed | 3,504 | November updates - Children of Morta, Outer Worlds, Afterparty, Erica, Pathologic 2 | 16:31 |
| 10. | JustinMyOpinion | 3,085 | Pathologic 2 Review - A creepy re-imagining does not disappoint | 7:14 |
| 11. | GamersPrey | 1,409 | Pathologic 2 - PAX East 2019 Trailer [HD 1080P] | 1:27 |
| 12. | bimbocatfood | 1,205 | PATHOLOGIC 2 | 31 | No One Puts Daniil In A Corner | Luka Plays | 24:23 |
| 13. | GamesByDesign | 903 | Pathologic 2 Blind (Part 9) | 2:52:41 |
| 14. | TheDeadSedd | 816 | Confronting Fathers Killer - Pathologic 2 - Part Thirteen - Intended Difficulty | 28:17 |
| 15. | shadicnion500 | 576 | Pathologic 2: Stream 13 opening to the close. | 0:00 |
| 16. | The CLOWN Show | 551 | PATHOLOGIC 2 - ALPHA GamePlay Walkthrough Part 5 (2018) HD | 47:23 |
| 17. | Trash N' Treasure | 538 | The Pathologic Experience | 0:00 |
| 18. | JustSomeCanadian | 501 | You Should Play Pathologic 1 & 2: Great Games That Aren't Fun | 29:16 |
| 19. | EmmaMCD | 407 | TRADING WITH KIDS - Pathologic 2 Ep. 15 EmmaMCD | 23:45 |
| 20. | GamingByGaslight | 379 | No Good Deed | Let's Try Pathologic 2 The Marble Nest Part 2 | 31:33 |
| 21. | Le Grand Rattrapage | 350 | Pathologic 2 | 2:15:58 |
| 22. | The Hidden Object Guru | 337 | What is Pathologic 2? | 41:39 |
| 23. | GWL Gaming | 273 | Pathologic 2 Easy 1000 Gamerscore | 2:41 |
| 24. | Just All in One Resource | 206 | Pathologic 2 - Either I'm Dreaming or I've Gone Insane | 37:31 |
| 25. | Totally Objective Reviews | 158 | Totally Objective Review - Pathologic 2 | 0:37 |
| 26. | Bunni and Husbunni | 156 | Bunni and Husbunni | Pathologic 2 | 9 | 1:06:03 |
| 27. | solododo | 154 | Pathologic 2 - Stream Six (FINAL) | 6:44:06 |
| 28. | Edge Case Collective | 147 | The Dramaturgy of Pathologic 2: How a video game uses epic theatre to incite revolution by profclary | 54:44 |
| 29. | Jon Renish | 120 | Steam Cleaning - Pathologic 2 | 39:32 |
| 30. | BlueMoonNyK | 108 | Some Fun Bits From: Pathologic 2 | 11:06 |
| 31. | Tehufn | 46 | Pathologic 2 | 1:45:46 |
| 32. | Tong Zou | 42 | Let's play Pathologic 2 (2019, PC) | 0:00 |
| 33. | Coffee Chat Gaming | 40 | Part 1: Dismissal, Twilight, Act I - Pathologic 2 Playthrough (No Commentary) | 55:32 |
| 34. | Baron Von PWN's Barony | 33 | Gouka demands more blood waters the roots; Continuing Pathologic 2 | 3:09:44 |
| 35. | Takeo Saeki | 28 | Pathologic 2 (ps4) | 42:45 |
| 36. | Vals NoisyToys | 27 | What's This? :: Pathologic 2 - #2 :: 05Jun19 ✅ | 1:57:06 |
| 37. | KaribouCanadien | 27 | Pathologic 2 Long GamePlay Fr 1 KaribouCanadien | 58:24 |
| 38. | therealme | 21 | Pathologic 2 - Calm Down | 1:01 |
| 39. | ZarahVT | 20 | Pathologic 2 -- It's just a plague, how bad could it be? [Part 1] | 2:50:01 |
| 40. | echambee | 20 | Hot Dog Steamé #18: Pathologic 2 Démo | 33:05 |
| 41. | Wolfsayianssj5 | 19 | The Weirdest Game I've Ever Played Thus Far - Pathologic 2 Ep.1 | 35:48 |
| 42. | GameHaunt | 17 | GameHaunt Plays Pathologic 2 | 1:35:21 |
| 43. | Shae VODs | 6 | Pathologic 2 ending | 2:49:11 |
| 44. | TnT Stream Archives | 1 | Pathologic 2 (Part 1) | 07.16.21 | 3:30:36 |
| 45. | saladspoonn | 0 | PLAYING A SPOOOOOKY GAME | 55:03 |
