| 1. |  DSPGaming | 943,294 | Prototype 2 playthrough pt68 (final) | 25:31 |
| 2. | Scribe | 65,795 | Let's Play Prototype 2 Part 24 - Final Boss [Alex Mercer] | 20:34 |
| 3. | Urbanboy732 | 34,229 | Prototype 2 GAWD Plays [Prototype 2] | 43:22 |
| 4. | Denonu Does Gaming | 31,725 | Prototype 2 - Hard Difficulty Let's Play Part 43 - Alex Mercer vs James Heller pt 2 - Live Comm | 11:16 |
| 5. | AMHarbinger | 26,261 | Prototype 2 - Alpha Wolf - Insane - Boss Fight Dr. Archer | 8:43 |
| 6. | Bob “W” Hall | 21,773 | Prototype 2: Story 19 - Alpha Wolf | 10:10 |
| 7. | Ninetails625 | 9,227 | [ PROTOTYPE 2 ] PROJECT LONG SHADOW | PLAYTHROUGH PART 2 | PS4 | 30:00 |
| 8. | A Crab Named Heller | 9,066 | Microsoft CLOSES Acti-Blizz Deal!! PlayStation Fanboys in DISBELIEF AND ENRAGED!! | 11:35 |
| 9. | Kasaru | 6,447 | Prototype - Playthrough Part 6 - No Commentary/Uncut (HD PS3 Gameplay) | 34:21 |
| 10. | Ronin Gaming | 4,542 | Prototype 2 RTC Part 14 - Proj Take Orions Soul | 17:59 |
| 11. | LANDAN2006 | 2,963 | Prototype 2 - Fighting and Consuming a Brawler!!! | 2:13 |
| 12. | TelliziPlus | 2,717 | Prototype 2 | 15:20 |
| 13. | MonkeyFlop | 2,461 | PS PLUS JANUARY PS3 Instant Game Collection 2015 IGC | 1:50 |
| 14. | TheOthersiders360 | 2,155 | Prototype 2 Playthrough - Part 6 (X360/PC/PS3) | 20:28 |
| 15. | Master Turkey | 2,134 | Prototype 2 - RPCS3 TEST (InGame) | 12:12 |
| 16. | FoxFire | 1,747 | Let's Play Prototype 2 - Part 4 (Xbox 360 HD Gameplay & Commentary) | 29:18 |
| 17. | RaSan69 | 1,743 | Prototype 2 walkthrough part 31 [Alpha Wolf] | 15:23 |
| 18. | ACKreszentia | 1,536 | Lets play - Prototype 2 | FINALE | James VS The creator | 36:22 |
| 19. | THE DARK 007 | 1,442 | Prototype 2: Psycho Brutal Kills - Vol.04 | 9:04 |
| 20. | Cablelinenetwork | 1,314 | Lizard Squad Hacks PlayStation Network 12/7/2014 | 1:32 |
| 21. | Revocane | 867 | Prototype: Part 9 | 45:21 |
| 22. | SoloBL | 744 | PlayStation Plus Free Game of The Month [PS3] - January 2015 - Prototype 2 | 33:33 |
| 23. | NearlySeniorCitizen Yetagamer | 541 | PROTOTYPE : Let's Play Bloody & Violent Action Games #9 | 20:56 |
| 24. | thewalkthroughking | 407 | Prototype 2 playthrough Part 40 HD Xbox 360 Final | 3:07 |
| 25. | BillsGaming | 396 | Prototype 2 Playthrough - Pt. 34 (Final) | 27:27 |
| 26. | Retro2New Gaming4You | 372 | Prototype 2-James Heller Story Playthrough (Pt30)-4/22/21 | 36:21 |
| 27. | LukRev68 | 306 | Prototype 2 - Part 23 PC Playthrough [HD] | 40:36 |
| 28. | NEOSTHEATER | 276 | Let's Play: Prototype 2! "Stealth Gone Awry!" [HD] | 12:16 |
| 29. | True Story | 259 | Prototype 2 - Final Boss Fight - Full Ending Scene | 10:39 |
| 30. | Shakepool | 152 | Let's Play Prototype (Part 29) The Tanks | 16:40 |
| 31. | Mr Akedo | 133 | Prototype -#5 - ALT THERE IS NO ALT! | 10:54 |
| 32. | Crytec NBOMB | 113 | [PROTOTYPE 2] Playthrough Part 9| James Gets Another Upgrade! | 23:30 |
| 33. | BrotherBlaccspider | 110 | Blaccspider plays Prototype 2 final stream.. | 53:42 |
| 34. | Not2NerdyENT | 109 | Prototype 2 part 10 ("Alpha Wolf", "Fall From Grace") | 36:33 |
| 35. | Thornejohny Gaming | 99 | Let's Play PROTOTYPE 2 Part 8 (OG PlayStation 4) | 2:31:45 |
| 36. | Krimson_Glaed | 92 | PROTOTYPE : WE'RE HELPING BLACKWATCH? | 21:04 |
| 37. | Jonlaw | 86 | Weekly Update Series #5: [Flawless GW] Update: Prototype 2 Lets Play/Blue Snowball (4.23.12) | 5:39 |
| 38. | kenneth2523 | 81 | Evolve never finds a match #bigAlpha | 3:39 |
| 39. | Jinxsyns | 75 | Let's play Prototype 2 Blind Episode 3 | 45:56 |
| 40. | Casas Plays | 73 | Prototype 2 - Let's Play - Part 7 | 58:51 |
| 41. | TheMeteoDragoon | 61 | [PROTOTYPE®2] Part 26 Helping Dana Mercer | 19:38 |
| 42. | dougbarrett619part2 | 53 | Lets play prototype part 18 the city of blood | 1:11:07 |
| 43. | Michael Reinert | 43 | Lets play Prototype 2 episode 4 | 2:10:31 |
| 44. | GHoStSoLo | 40 | Prototype 2 (REMASTERED) Walkthrough Gameplay Part 15 - Alpha Wolf | 10:26 |
| 45. | The Fireplays | 38 | This guy SOLOS ALL SYMBIOTES | Prototype 2 Play-through | 16:40 |
| 46. | Rijan Archer Music Group | 36 | Prototype 2 | Higher Ground | HD | 60 FPS | Crazy Gameplays!! | 17:26 |
| 47. | i5leeps | 35 | Prototype 2 Gameplay Walkthrough Part 19 - ALPHA WOLF | 18:48 |
| 48. | Killa Penguin | 34 | Prototype - Parkour, Floating, and Missiles | 1:11 |
| 49. | Darth_Gamers | 34 | [Prototype 2] - Let's Play Story - Finale/Credits | 47:44 |
| 50. | replayFaktor | 34 | PROTOTYPE 2 (PS4 Pro) | Alpha wolf mission (vs. Dr. Archer) | 10:33 |
| 51. | Bmoodyj | 31 | Prototype 2 Gameplay 1080p PC,PS3,X360 60fps | Alpha Wolf - Part 19 | 21:01 |
| 52. | Awkward Gaming Girl | 30 | Let's play prototype 2!😎😎 | 40:34 |
| 53. | Butcher in Gaming | 29 | Prototype PS5 playthrough The Ultimate Predator PART 12 HOW ALEX MERCER BECAME A APEX PREDATOR | 1:05:42 |
| 54. | Rocket Rabbit (Commentaries) | 28 | Let's Play Prototype 2 Part 16: Showing Death Flags to the Alpha Wolf. | 16:34 |
| 55. | Darth Revan | 28 | DarthRevan Plays Prototype episode #11 | 44:31 |
| 56. | Cloud Striph | 26 | Let's play prototype 2 ep 3 | 4:06:49 |
| 57. | Bricksgaming710 | 25 | #playstationpro prototype part 1 | 38:19 |
| 58. | The silent pc gamer | 23 | PROTOTYPE 2 RADNET EDITION - Playthrough Part 1 - No commentary | 22:46 |
| 59. | worldwar14s | 23 | Lets Play some [Prototype 2] part (22) 47 min Special | 47:16 |
| 60. | Jesse Culp | 19 | Prototype 2 By Jesse Culp Mask On City Wide | 3:14:07 |
| 61. | Stealth1986 | 16 | Let's Play: Prototype 2 (Beginning Gameplay) | 41:56 |
| 62. | N1GHTM4RE | 15 | [PROTOTYPE2]| I'm Baacckk! Lets play some Nostalgia! | 2:13:55 |
| 63. | FSD2000 | 15 | PROTOTYPE 2 (PS3) PART 9- A MAZE OF BLOOD & ALPHA WOLF | 42:38 |
| 64. | GoldTheWriter | 13 | ALEX THE GREAT AND POWERFUL | Let's Play [PROTOTYPE 2] | 24:14 |
| 65. | Next GamesLP | 12 | [PROTOTYPE®2] PS4 Pro| | 10:13 |
| 66. | TheOMEGAHarris HD | 11 | [PROTOTYPE®2] Play Through Part 1 | 30:00 |
| 67. | ONYXCON | 10 | Prototype 3rd play through pt 1 BUSTIN PIXELS SHOW! | 54:28 |
| 68. | Noctem0_Rebel Gamer | 9 | Let's Play [PROTOTYPE 2] | 25:09 |
| 69. | RockJustice Videos | 7 | Prototype LP pt. 19 - No Commentary | 16:27 |
| 70. | Allen The Geek | 7 | Let's Play with Allen: Prototype - damn... | 1:38:01 |
| 71. | Trone Hunter | 7 | Prototype 2 - Gameplay Walkthrough - Part 17-ALPHA WOLF- (PC-1080p) GTX970 | 14:23 |
| 72. | Inductive Gaming | 6 | Prototype 2 Biohazard Edition #7: Alpha Wolf | 24:08 |
| 73. | Roku the saiyan | 5 | Ian plays prototype 2 | 37:59 |
