| 2026-05-10 |  Gameplay Streak | 433 | SERIOUS SAM 2 Full Game Campaign [4K60FPS] | 0:00 |
| 2025-12-07 | AlexanderGamer | 1,380 | Serious Sam 2 ONLINE Xlink Kai Xbox Classico (XEMU) Ao Vivo | 0:00 |
| 2025-06-07 | Hardcore Gamer: Zero Blá Blá Blá | 1,620 | A IRA DE SAM: O FIM DA INSTITUIÇÃO MENTAL | Serious Sam II SÉRIE GAME EP FINAL | 0:00 |
| 2024-09-08 | GuinhOOver | 3,430 | Serious Sam SE | #VR #Quest2 #Quest3 #FPS #PSVR2 #SeriousSam | 0:00 |
| 2024-07-20 | Gachonky | 36,100 | SERIOUS SAM 2 - Level 42 Mental Institution Gameplay Walkthrough [4K60FPS] - No Commentary | 42:04 |
| 2024-07-17 | HG4K | 219 | Serious Sam 2 Gameplay [4K 60FPS] - FULL GAME | 7:41:32 |
| 2024-05-06 | Wandreson SN | 4,160 | Serious Sam 2 Winlator 6.1 SD 8gen3 #redmik70pro #viral #shorts #winlator | 0:49 |
| 2024-05-03 | Thiago-Skull Games | 883 | Serious Sam: muito tiro e correria nesse jogo | 34:46 |
| 2024-01-06 | igiul | 265 | Serious Sam Collection - PC Gameplay RADEON 800 MHZ 1.84 TFLOPS | 10:30 |
| 2023-09-15 | NenevS | 4,750 | MILHÕES DE INIMIGOS AO MESMO TEMPO!!! Serious Sam 2 | 1:41:10 |
| 2023-09-01 | Espaço de Jogos | 1,370 | To play Serious Sam 2 #shorts #serioussam2 #comedy #memes #gameplay | 0:16 |
| 2023-08-09 | VLAD DIEZEL GAMES JR | 92 | SERIOUS SAM ©2 | 50:20 |
| 2022-06-23 | Nɇcrøso | 239 | Serious Sam II Multiplayer (2022) | 14:00 |
| 2022-05-25 | DanilegoPlays | 6,360 | Serious Sam 2 #42 - A Instituição Mental (pt-br)(Serious Mode)[FINAL] | 1:05:50 |
| 2022-04-12 | CineVibes | 402 | Serious Sam 2 - Lembra desse Jogo? Live ON | 1:18:00 |
| 2022-04-11 | Do Começo | 14,400 | Serious Sam live do jogo | 38:49 |
| 2022-04-01 | GabrielOnuris | 30,200 | Serious Sam 2: A ovelha negra da franquia | 13:25 |
| 2022-03-16 | RTecnológico | 808 | LIVE DE SERIOUS SAM 2 PT 7!! FINAL. | 2:56:39 |
| 2022-03-13 | Kindred | 331 | serious sam 2 froze my pc | 0:09 |
| 2021-07-17 | Slenderman Games | 3,440 | QUATRO IDIOTAS NUM JOGO ESQUIZOFRENICO/Serious Sam 2 (Ft.Fellipy CZ, MulaBR E JL) | 9:36 |
| 2021-06-01 | Now Loading Please Wait | 3,920 | Serious Sam II - Xbox | 0:40 |
| 2021-04-23 | Um_BR | 382 | Serious Sam 2. Jogatina de Teste II | 1:19:12 |
| 2020-11-22 | Literalmente{Game} | 2,870 | Emulação - Serious Sam II in-game no CxBx-Reloaded (XBox) | 13:26 |
| 2020-08-12 | AlanGHP7 | 2,020 | SERIOUS SAM 2 INFINITO-FINAL LONGO-#16 | 0:00 |
| 2020-05-21 | AlanMix | 119 | game design de 2001 | 1:14 |
| 2020-03-14 | Canal Virtual | 71,900 | SERÁ QUE SERIOUS SAM 2 RODA EM PC FRACO? | 22:20 |
| 2020-01-02 | KURUMIN GAMES | 1,360 | Serius Sam 2 | 32:28 |
| 2019-07-05 | BESTINHA GAMER | 12,600 | UNTURNED NOVO MAPA VERSÃO 3.9.9.5 EXPLORANDO O MAPA LIVE AOVIVO 2019 PC LIXO SEM PLACA DE VIDEO | 1:33:25 |
| 2019-01-21 | HannyS2 | 15,300 | SILVERIO O DINOSSAURO (Serious Sam II) | 8:43 |
| 2018-09-19 | Game Vs Games | 231 | SERIOUS SAM 2 XBOX CLASSÍCO | 34:36 |
| 2016-07-13 | SANTANA TECH | 37,800 | [SS] #1 - Serious Sam 2 | 8:34 |
| 2016-03-20 | KingDesu | 1,030 | Serious Sam 2 ''Adeus Strike! - Momento morrendo Bagarai SUPREMO!'' | 26:34 |
| 2016-01-30 | FernandosonicBR | 33,600 | AO VIVO JOGANDO -SERIOUS SAM 2-e csgoo | 1:50:25 |
| 2014-10-18 | PCG - Jogatinas de PC | 165 | Serious Sam 2 - Easter Egg Duke Nukem | 0:30 |
| 2012-05-22 | henrique9415 | 36,900 | Gameplay Serious Sam 2 | 11:35 |
| 2007-06-13 | CARLOS CP | 345 | Serious Sam 2 _ Gameplay | 3:21 |
