| 1. |  Annoying Orange Gaming | Annoying Orange Plays - SLITHER.IO: #1 BIGGEST SNAKE!!! | 11,225 | Let's Play |
| 2. |  Jelly | My GIRLFRIEND Helps Me CHEAT In SLITHER.IO! | 7,194 | Let's Play |
| 3. | FGTeeV | SLITHER.io #2: vs. AGAR.io #4 vs. SUPER SNAKE.io #1 (FGTEEV Duddy Plays & Ranks All 3!! Favorite??) | 6,091 | Let's Play |
| 4. |  EthGoesBOOM | TOY CHICA PLAYS: Slither.io || GET ALL THE SHINY THINGS!!! | 5,658 | Let's Play |
| 5. | Annoying Orange Gaming | Annoying Orange Plays - Slither.io #2 | 2,836 | Let's Play |
| 6. | SquiddyPlays | SquiddyPlays - SLITHER.IO - Rage Quit! | 2,461 | Let's Play |
| 7. |  Polo | VAIS-JE DEVENIR LE PLUS GROS SERPENT ? | 1,495 | Let's Play |
| 8. |  Luisito Kingdom Gaming | Slither.io - Golpes Extremos | 1,430 | Let's Play |
| 9. | Amy Lee (Amy Lee33) | Amy Lee Plays Slither.io! | WE GET ON THE LEADERBOARD! High Score! | Amy Lee33 | 1,201 | Let's Play |
| 10. | Vikkstar123 | BEST START EVER! - 30,000+ SIZE! - SLITHER.IO #2 with Vikkstar | 1,180 | Let's Play |
| 11. |  React Brasil | React 1424 JOLONGA DETESTA NOVA YORK - SLITHER IO (Pinto Plays) | 995 | Let's Play |
| 12. | SquiddyPlays | SquiddyPlays - WORM.IS - SO MUCH RAGE! | 898 | Let's Play |
| 13. | Polo | LE PLUS GROS SERPENT DE NOTRE PARTIE ! | 868 | Let's Play |
| 14. | Weegeepie | Luigi Plays: SLITHER.IOOO | 816 | Let's Play |
| 15. | Polo | SERAI-JE AU TOP AUJOURD'HUI ? | 799 | Let's Play |
| 16. | Polo | MON PLUS GRAND RIVAL | Slither.io | 795 | Let's Play |
| 17. | SeeDeng | SANS PLAYS SLITHER.IO (Undertale Roleplay) | 769 | Let's Play |
| 18. | iX | MOPE.IO 200 IQ PLAYS!! // Best New Trolling (Mope.io Funny Moments) | 727 | Let's Play |
| 19. | Amy Lee (Amy Lee33) | Amy Lee Plays Slither.io! | Meet Mr Wiggles! | Slither.io Lets Play | Amy Lee33 | 713 | Let's Play |
| 20. |  Alphastein | ALPHASTEIN HAT 20,0000 SCORE in SLITHER.IO | 670 | Let's Play |
| 21. | Muca Muriçoca | EU NÃO MORRI - Slither.io (ft. Felps) | 643 | Let's Play |
| 22. |  KeysJore | Let's Play SLITHER.IO Deutsch - Snake Skills zahlen sich endlich aus! | 626 | Let's Play |
| 23. | Ricky And Zai | LICK MY FACE! | Slither.io | 616 | Let's Play |
| 24. | SuperMega | SuperMega Plays SLITHER.IO - EP 1: Snake Eat Snake World | 599 | Let's Play |
| 25. | GermanLetsPlay | Wie die Zuschauer von GermanLetsPlay ihm die Ehre nahmen. | 591 | Let's Play |
| 26. | SB737 | SLITHERING INTO TROUBLE! | Slither.io | 584 | Let's Play |
| 27. | ToonFirst | Slither.io - Slitherio Monster Love | Epic Plays | 576 | Let's Play |
| 28. | FiFqo | NOVÝ REKORD!! 55000+ MASS | slither.io #5 | SK Let's play | facecam | HD 60FPS | 541 | Let's Play |
| 29. | Amy Lee (Amy Lee33) | Slither.io TOP SCORE! WE ARE NUMBER ONE! | Slither.io Lets Play | Amy Lee33 | 508 | Let's Play |
| 30. | ToonFirst | Slither.io - The Highest Risky Plays #2 | Slitherio Epic Moments | 446 | Let's Play |
| 31. | FiFqo | SOM NAJVAČŠÍ HAD! - 40K MASS | slither.io | SK Let's play | facecam | HD 60FPS | 412 | Let's Play |
| 32. | lonniedos | SLITHER.IO - THE NEW AGAR.IO with SNAKES! (iPhone Gameplay Video) | 382 | Let's Play |
| 33. | Mr. Caricature | Snake.io - Vulper - Zero to Hero | 379 | Let's Play |
| 34. | OtakMori Vtuber Clips | Okayu's Personality Changed When She Plays Slither.io【Hololive | Eng Sub】 | 362 | Let's Play |
| 35. | PooDot StinkPants | SLITHER.io (OPHIDIOPHOBIA SCOLECIPHOBIA NIGHTMARE) | 352 | Let's Play |
| 36. |  Wedry | JÁ JSEM ÚPLNĚ V KLIDU! 🙃(Slither.IO) | 347 | Let's Play |
| 37. | AbooTGamer | Gulper.io - MINHOCAS ESQUELETOS // ESSE JOGO É MELHOR QUE SLITHERIO E WORMATE?? ‹ AbooT › | 344 | Let's Play |
| 38. | Be Challenger | FAKER Plays Slither.io and Gets TOP 1! - SKT T1 Faker Playing Slither.io (Reupload) | SKT T1 Replays | 335 | Let's Play |
| 39. | DOLLASTIC PLAYS! | Dragon Slither.io in Roblox?!?!!!! - Roblox Dragon Riders - DOLLASTIC PLAYS! | 323 | Let's Play |
| 40. | ToonFirst | Slither.io - World No.1 Sneaky Snake | Slitherio Epic Plays | 305 | Let's Play |
| 41. | Annoying Orange Gaming | Grapefruit Plays - Slither.io: GIANT KILLER CATERPILLER! | Annoying Orange | 301 | Let's Play |
| 42. | ToonFirst | Slither.io - Lovely Jelly Skin Invasion | Slitherio Plays | 286 | Let's Play |
| 43. | SuperMega | SuperMega Plays SLITHER.IO - EP 2: Moist Snakes | 286 | Let's Play |
| 44. | KeysJore | Let's Play SLITHER.IO Deutsch - Schlong Cena auf dem Pausenhof | 285 | Let's Play |
| 45. |  ChrisWhippit | ÄR GULPER.IO BÄTTRE ÄN SLITHER.IO? | 285 | Let's Play |
| 46. | Fandroid GAME | Slither.io Mega Fun Giant Snake Let's Play ► Fandroid the Musical Robot! | 277 | Let's Play |
| 47. | Mrmobilefanboy | TOP 10!!! || SLITHER.IO || Multiplayer || Let's Play Slither.io [Deutsch/German HD+] | 277 | Let's Play |
| 48. | Generikb | "LIKE AGAR.IO BUT WITH SNAKES!!!" - Slither.io - SWAG (Some Weird Ass Games) 1080p HD Gameplay | 272 | Let's Play |
| 49. | TSMC - Minecraft | Donald Trump Plays Slither.io? | 267 | Let's Play |
| 50. | FiFqo | ČÍTERI V SLITHERIU! | slither.io #8 | SK Let's play | facecam | HD 60FPS | 260 | Let's Play |
| 51. | k3lp | Swordz.io - LEVEL 26 IN PVP MODE // 144.450 SCORE LEVEL MAX (WORLD RECORD) - k3lp | 253 | Let's Play |
| 52. | Annoying Orange Gaming | Gaming Grape Plays - SLITHER.IO Pewdie Pie Spotting!! | 244 | Let's Play |
| 53. | FiFqo | ELEKTRICKÝ CHALLENGE! | slither.io #9 | SK Let's play | facecam | HD 60FPS | 238 | Let's Play |
| 54. | Sev | ICH HAB DEN LÄNGSTEN WURM | Lets Play Slither.io (Deutsch/German) | 235 | Let's Play |
| 55. | ToonFirst | Slither.io - Pokemon Go Snake 'Gotta Get Them ALL' | Slitherio Epic Plays | 226 | Let's Play |
| 56. | ToonFirst | Slither.io - Small Trolling World Biggest Giant Snake | Slitherio Funny Plays | 223 | Let's Play |
| 57. | ToonFirst | Slither.io - Small Trolling World Biggest Giant Snake | Slitherio Funny Plays | 220 | Let's Play |
| 58. | ToonFirst | Slither.io - PVZ Chomper Snake World Biggest Snake | New Custom Skin Epic Plays | 215 | Let's Play |
| 59. | FiFqo | MOBILNÍ HADI! | slither.io #7 | SK Let's play | facecam | HD 50FPS | 212 | Let's Play |
| 60. | ToonFirst | Slither.io - Boost Only Challenge | Slitherio Trolling Plays | 211 | Let's Play |
| 61. | ToonFirst | Slither.io - Small Vs Giants w/ New Invisible Ninja Skin | Slitherio Epic Plays | 211 | Let's Play |
| 62. | lonniedos | Slither.io - WORST THING THAT CAN EVER HAPPEN IN SLITHERIO - Part 2 (iPhone Gameplay Video) | 206 | Let's Play |
| 63. | ZaiLetsPlay | EAT THE BOOTY! - Slither.io | 204 | Let's Play |
| 64. | YuB | SLITHER.IO IS PRETTY FUN! [Slitherio Gameplay Highlights] | 198 | Let's Play |
| 65. | Generikb | "YES YES YES...NOOOOOOOO!!!" - Slither.io - SWAG (Some Weird Ass Games) 1080p HD Gameplay | 194 | Let's Play |
| 66. | FiFqo | VYSNENÁ HRA! | Worm.is | SK Let's play | facecam | HD 60FPS | 194 | Let's Play |
| 67. | ToonFirst | Slither.io - New Cutest Cone Head Skin | Slitherio Plays | 187 | Let's Play |
| 68. | ToonFirst | Slither.io - Minecraft Snake Enderman | Slitherio Epic Plays | 181 | Let's Play |
| 69. | LETSPLAYmarkus | Let's Test # 173 🐍 SLITHER.IO | 180 | Let's Play |
| 70. | ToonFirst | Slither.io - The Cutest DOGE Snake - Slitherio Epic Plays | 178 | Let's Play |
| 71. | FiFqo | SLITHER.IO MÓDY!! 5000+ za 30 sekúnd | slither.io #6 | SK Let's play | facecam | HD 50FPS | 174 | Let's Play |
| 72. | ToonFirst | Slither.io - Epic Small Trolling Giant Snakes | Slitherio Epic Plays | 171 | Let's Play |
| 73. | Sev | SLITHER.IO TIPPS & TRICKS | Lets Play Slither.io (Deutsch/German) | 170 | Let's Play |
| 74. | Debitor | VERSUS GLP | Slither IO Multiplayer | 164 | Let's Play |
| 75. | Bador | PLATZ 1! ULTIMATIVE TIPPS UND TRICKS - Slither.io -Lets play - Deutsch - German | 164 | Let's Play |
| 76. | ToonFirst | Slither.io - World Biggest MLG Snake | New Spiderman Skin - Slitherio Epic Plays | 154 | Let's Play |
| 77. | GrayStillPlays | STARVE.IO - FREE SURVIVAL BASE BUILDING GAME! 1st Place Leaderboard - Starve.io Gameplay Highlights | 151 | Let's Play |
| 78. | Mrmobilefanboy | SLITHER.IO MULTIPLAYER mit Mabuel & Fred || Let's Play Slither.io [Deutsch/German HD+] | 149 | Let's Play |
| 79. | ToonFirst | Slither.io - Super Giant Mario Bros. Snake | Slitherio Epic Plays | 147 | Let's Play |
| 80. | FiFqo | AKO SA (ne)DOSTAŤ NA PRVÉ MIESTO! - slither.io #3 | SK Let's play | facecam | HD 60FPS | 144 | Let's Play |
| 81. | ToonFirst | Slither.io - Epic Snake Vs Giants w/ Most Risky Plays | 138 | Let's Play |
| 82. | FiFqo | FAILÍME NA STRÍME! - slither.io #2 | SK Let's play | facecam | HD | 134 | Let's Play |
| 83. | ToonFirst | Slither.io - Tiny Snakes Everywhere | Slitherio Awesome Plays | 128 | Let's Play |
| 84. | Crocodileandy | Ich schlage GermanLetsPlay in Slither.io - Slither mit Croco | 128 | Let's Play |
| 85. | Bador | SLITHER.IO FANS... - Slither io -Lets play - Deutsch - German | 125 | Let's Play |
| 86. | k3lp | Evowars.io - PROTECT THE ORBS! // HUGE PILE OF ORBS! (new minigame + lvl.0 dark night!) - k3lp | 122 | Let's Play |
| 87. | Otto Van Thom | SLITHER.IO 🐍 deutsch Let's Play | Es beginnt als kleines Würmchen | OttoVanThom | 122 | Let's Play |
| 88. | biggranny000 | [Slither.io] - Lets Play Ep 1 - Our First Adventure! | 122 | Let's Play |
| 89. | ToonFirst | Slither.io - All Diamond Minecraft Skins Plays - Slitherio Epic Plays | 118 | Let's Play |
| 90. | Bador | ERSTER SLITHER.IO HACK - Lets play - Deutsch - German | 117 | Let's Play |
| 91. | ToonFirst | Slither.io - The Return Of King Giant Snake Trolling | Slitherio Epic Plays | 107 | Let's Play |
| 92. | LENDA Gameplays | Slither.io - 513k!!! NEWEST WORLD RECORD!!!!! MEIA MILHA!!!! | 107 | Let's Play |
| 93. | ToonFirst | Slither.io - Evil Scary Snake w/ Trolling Giant Snakes - Slitherio Epic Plays | 102 | Let's Play |
| 94. |  Juniorsky | LEPSZE NIŻ AGAR.IO? SLITHER.IO? | Let's Play Brutal.Io (PL/Po Polsku) | 102 | Let's Play |
| 95. | Raquel Gamer | SLITHER.IO - FOI CULPA DO LAG | 102 | Let's Play |
| 96. | ToonFirst | Slither.io - Giant Happy Snakes Dominator | Slitherio Epic Plays | 101 | Let's Play |
| 97. | ToonFirst | Slither.io - Small Troll Vs Giant Snakes - Slitherio Epic Plays | 99 | Let's Play |
| 98. | ToonFirst | Slither.io - Giant Snakes Eat Small Weedle w/ Pokemon Go Mod | Slitherio Epic Plays | 98 | Let's Play |
| 99. | Annoying Orange Gaming | The Snakes are Back!!! (AO Plays Slither.io) | 96 | Let's Play |
| 100. | ToonFirst | Slither.io - I Can't 'Do' It w/o Hacking | Slitherio Epic Plays | 92 | Let's Play |
