| 1. |  RetroGame.Stream | 2,539,446 | Saturn Sonic Jam - Sonic & Knuckles - Knuckles Playthrough Normal Mode | 1:17:36 |
| 2. | LankyBox | 847,097 | BEST SONIC VIDEOS EVER! (SONIC.EXE VS ALPHABET LORE, SCARY 3AM SONIC MOVIE, SONIC OBBY, & MORE!) | 1:48:55 |
| 3. | cobanermani456 | 147,967 | Sonic 3 and Knuckles - Playthrough Part 1 LIVESTREAM | 3:59:27 |
| 4. | ZetaPlays | 10,981 | Let's Play Sonic and Knuckles 04 - Gotta Hold My Breath In Space (Also Briefly Be Knuckles) | 27:04 |
| 5. | NintendoComplete | 10,941 | Sonic & Knuckles (Genesis) Playthrough | 1:16:48 |
| 6. | OGRagebreak Gaming | 9,408 | Super Mecha Revenge!😤| Let's Play Sonic & Knuckles #04 (GEN) [Finale!] | 23:56 |
| 7. | DSJ Brigade | 5,491 | DSJ Plays Sonic 3 and Knuckles 037: Now on to the Sonic and Knuckles Stages | 19:11 |
| 8. | Tails' Channel | 5,403 | Matt and PKSparkxx (DatHottneSS) Play: Sonic 3 & Knuckles - Part 13 (FINALE) | 13:40 |
| 9. | SuperNardful | 5,337 | SuperNardful Plays Sonic & Knuckles (Full Game) | 2:06:40 |
| 10. | Leo Draconis | 5,024 | Sonic and Knuckles Knuckles Playthrough Complete | 5:28 |
| 11. | Sport Cards Brass Trains VideoGames | 3,480 | Sonic & Knuckles Sega Genesis PlayStation 2 Long Play Run | 1:33:38 |
| 12. | SG Wolfie | 3,346 | Wolfie Plays Sonic & Knuckles: Newtronic Panic (Pre SAGE 2020) - Werewoof Reactions | 14:42 |
| 13. | Shiro Paradox | 2,630 | Sonic 3 & Knuckles Hard Bosses Edition 2 ~ Playthrough (v400.0) (Knuckles) | 17:46 |
| 14. | mrgameandpie | 2,224 | Lets Play Sonic and Knuckles Part 7: Victory hog | 11:33 |
| 15. | Crow Continuum | 1,852 | Crow Plays Sonic & Knuckles with Sonic the Hedgehog 3 (Genesis) | 8:02 |
| 16. | Cyborcat | 1,697 | Let's Play Sonic & Knuckles (and chat) 3 | 1:50:02 |
| 17. | Funky G | 1,252 | Let's Play Sonic & Knuckles - Knuckles Playthrough | 1:30:46 |
| 18. | Thundershot | 1,245 | Sonic Mania Knuckles Playthrough Part 10- Lava Reef Zone | 29:47 |
| 19. | rynogt4 | 1,242 | Sonic 3 & Knuckles - Hidden Palace Zone & Sky Sanctuary Zone [Tails] (Let's Play Part 24) | 7:54 |
| 20. | Hotboy fresh / GPG Gaming | 958 | GPG let's play K.T.E / sonic & knuckles lava reef 2 hidden palace & sky sanctuary final battle | 13:46 |
| 21. | Raiko☆Star『VTuber』 | 948 | Let's play Sonic & Knuckles with space alien vtuber Raiko Star | 2:08:15 |
| 22. | Axel Lazuli | 930 | TeelaKatana - Sonic & Knuckles Playthrough! | 4:17:42 |
| 23. | Animus | 925 | Let's Play Sonic 3 & Knuckles Part 12- Sky Sanctuary Zone | 4:15 |
| 24. | Perfect Playthrough | 748 | Perfect Playthrough: Sonic Origins Plus 50 | 58:47 |
| 25. | Let's Play With Brigands | 723 | Let's Play Sonic 3 and Knuckles (Episode 1) | 1:00:24 |
| 26. | ShinSubSmoke072Inaba | 670 | Sonic 3 & Knuckles (Knuckles Playthrough) Part 6: Marble Garden Zone Act 1 | 9:18 |
| 27. | Sega Revolution | 664 | Let's Play Sonic & Knuckles: Final Episode Part 2 - End of Sonic & Knuckles | 16:28 |
| 28. | RetroGamerKevin | 634 | Playing Sonic Mania! [Stream] (PS4) - Sonic and Knuckles Playthrough, Part 3 Finale | 1:56:25 |
| 29. | Cutman Plays! | 516 | Dj CUTMAN Remixing Sonic and Knuckles [Highlights] - Cutman Plays | 15:40 |
| 30. | Faithful Gamingu | 433 | Sonic 3 & Knuckles 100% All Chaos Emeralds Sonic Playthrough | 2:21:40 |
| 31. | chuckfinleLP | 364 | lets play sonic and knuckles: part 8: The Doomsday Zone | 40:04 |
| 32. | Soulkrist | 341 | Hidden Palace/Sky Sanctuary - Sonic & Knuckles [Knuckles Playthrough], Let's Play, Pt. 5 | 14:55 |
| 33. | SnapClickKat | 238 | Drunk? ♥SONIC MEGA COLLECTION♥ part 6(on Dolphin) -Live Stream!! (Drink here :D) | 1:55:11 |
| 34. | The D-Pad ᴜɴᴩᴀᴜꜱᴇᴅ | 224 | Sonic & Knuckles | THE SUPER SONIC LET'S PLAY | ᴜɴᴩᴀᴜꜱᴇᴅ | 1:32:58 |
| 35. | Builder Mario - Nintendo Gameplays | 222 | Sonic Plays Sonic & Knuckles Part 2 | 12:36 |
| 36. | Omega Ace Gaming | 205 | Sonic & Knuckles Stream - For KAMUI PLAYS and SpeedKing125 | Omega Ace Gaming | 2:32:50 |
| 37. | Hipojoe | 176 | Lets play Sonic and Knuckles for the Sega Gen! Part 2 | 31:23 |
| 38. | LITTLE | 168 | Sonic 3 & Knuckles (Genesis) Knuckles' story playthrough | 1:17:13 |
| 39. | OmySpy | 141 | Sonic & Knuckles | Let's Play Part 5 | 21:16 |
| 40. | Hibiki TMD | 140 | Hibiki Plays! : SONIC & KNUCKLES for SEGA GENESIS | 20:51 |
| 41. | YinYangTK | 132 | SONIC & Knuckles [SEGA GENESIS] First Playthrough MISSION FAILED 🤣 | 1:38:51 |
| 42. | Sam Pae | 130 | Sonic & Knuckles (Genesis) - Playthrough | 2:15:07 |
| 43. | Drak & Shadow Let's Plays | 128 | Drak and Shadow LP's: Sonic 3 & Knuckles (Knuckles) Part 1 - Wait Knuckles is the HERO!?!?!? | 11:10 |
| 44. | ViewtifulTV | 101 | Retro - Sonic & Knuckles + Sonic 3 FULL playthrough! (Nintendo Switch) | 3:17:38 |
| 45. | Eric Corp Incorporated | 89 | Sonic the Hedgehog 3 & Knuckles (Genesis / Mega Drive) Playthrough Part 8 (Tails - Part 4 FINAL) | 47:34 |
| 46. | mdmax09 | 88 | Sonic and Knuckles for the Genesis on the PS3 with Mikey's VideoGame Madness Commentary | 25:34 |
| 47. | KingSuperOne | 87 | Sandopolis/Lava Reef/Hidden Palace Zone (Sonic 3 & Knuckles) | Sonic Origins | 37:07 |
| 48. | Devasia Mentality | 84 | Devasiamentality Plays Sonic & Knuckles Finale | 27:23 |
| 49. | AndreBreland213 | 76 | Sonic Mania PS4 (1080p) - Super Sonic & Knuckles Playthrough FINALE ROAD TO SONIC MANIA PLUS | 32:36 |
| 50. | SonicMan2500 | 47 | Let's Play Sonic The Hedgehog 3 & Knuckles Pt.11 - Hidden Palace Zone & Sky Sanctuary Zone | 10:51 |
| 51. | sonicdx17 | 43 | Sonic 3 & Fluttershy Playthrough Part 11 Hidden Palace & Sky Sanctuary Zones | 8:50 |
| 52. | The Negative Ion | 33 | Convince Me to Like Sonic 3 & Knuckles - Knuckles Playthrough | 3:49:56 |
| 53. | The Maddieverse - Official Channel | 25 | Sonic & Knuckles Collection Let's Play #1: Angel Island | 14:07 |
| 54. | Red Legend | 24 | Let's Play: Sonic 3 & Knuckles - 100% Complete! #7 | 14:30 |
| 55. | MightyWolfTV | 21 | MWTV Arcade Plays | Sonic & Knuckles (#1) | No Commentary | 1:42:48 |
| 56. | StoneTheGamer | 19 | Let's Play Sonic & Knuckles! One day Challenge Part 2! (No commentary) | 55:49 |
| 57. | Teddy Kong Country | 13 | Sonic and Knuckles Playthrough (no commentary) | 2:11:45 |
| 58. | BlackFlame731 | 11 | Sonic Mania Plus - Knuckles & Knuckles Playthrough Part 13 - Final Boss & Ending | 5:16 |
| 59. | theratking | 10 | Sonic and Knuckles Origins Full Playthrough | 59:59 |
| 60. | TurflamicGaming420 | 9 | Ffej himself plays Sonic and Knuckles | 15:53 |
| 61. | The Sharkopath | 7 | Sonic & Knuckles [Full Playthrough] Knuckle Up! | Twitch Livestream | 3:27:44 |
| 62. | Ghosty Gaming | 6 | Let's Play Sonic & Knuckles Part 2 | 1:09:55 |
| 63. | Toana | 5 | Let's Play-Sonic 3 Complete-Part 8 | 18:06 |
| 64. | MrGTGS | 3 | Sonic and Knuckles plays Sonic forces | 7:22 |
| 65. | RetroLand | 3 | Preacherman plays: sonic and knuckles. | 3:49 |
| 66. | knuxtoast | 1 | lets play s3&k part 5 ice is nice | 20:55 |
