| 1. | Flashgame Walkthroughs | Submachine 4 - Walkthrough | 63,844 | Walkthrough |
| 2. |  mindscapejem | Submachine 4 speed run - Out with all secrets under 10 minutes! | 20,676 | |
| 3. |  LAHKW Walkthrough Channel | Submachine 4 : The Lab (22 secrets) - Walkthrough PC | 14,607 | Walkthrough |
| 4. |  Matt Omega | Let's Play: Submachine 4: The Lab - Part 1 | 3,542 | Let's Play |
| 5. | passthehanky | Let's Play Submachine 4: The Lab! 1: Quantum Leap | 3,037 | |
| 6. | Matt Omega | Let's Play: Submachine 4: The Lab - Part 2 | 2,280 | Let's Play |
| 7. | passthehanky | Let's Play Submachine 4: The Lab! 3: Putting those secrets to good use | 2,149 | |
| 8. | LAHKW Walkthrough Channel | Submachine : 32 Chambers - Walkthrough PC | 2,002 | Walkthrough |
| 9. | passthehanky | Let's Play Submachine 4: The Lab! 2: More walks down memory lane | 1,365 | |
| 10. |  Manderby | Submachine Universe Let's Play #17 German (all theories read in English) | 653 | |
| 11. |  Zee_ 03 | Sic Mundus Creatus Est - Submachine [part 2] [eps 4 : The Lab & eps 5 : The Root] | 642 | |
| 12. | Manderby | Submachine 4: the Lab Let's Play #1 German | 474 | |
| 13. | Manderby | Submachine Universe Let's Play #24 German (all theories read in English) | 470 | |
| 14. | Manderby | Submachine 4: the Lab Let's Play #3 German | 426 | |
| 15. | Manderby | Submachine 4: the Lab Let's Play #2 German | 397 | |
| 16. | Manderby | Submachine 4: the Lab Let's Play #4 German | 366 | |
| 17. | Manderby | Submachine 4: the Lab Let's Play #5 German | 349 | |
| 18. | 47PlanetBaxterian | Submachine Episode 4 | 303 | |
| 19. |  Anna Mieke | Playing Valve's The Lab on The HTC Vive | 277 | |
| 20. | Jatsko2 | Submachine 3 / AA / 4 puzzle & gameplay commentary w/ smushy64 | 195 | |
| 21. | LAHKW Walkthrough Channel | Submachine 4 : The Lab Soundtrack | 135 | |
| 22. | TerribleAtGames - ripped off left and right | Submachine 4: The Lab | Secrets summary | 114 | |
| 23. | Ragny | Let's bumble through Submachine 4 - The Lab | 95 | |
| 24. |  Prongsley | Submachine (Part 11) - Secret Room | 86 | |
| 25. | Prongsley | Submachine (Part 10) More Notes and an Elusive Secret | 73 | |
| 26. | radio4active | Submachine 4 - The Lab | 67 | |
| 27. | Studio ManHot | Submachine 4 | 62 | |
| 28. |  MASHIRO a.k.a. limeglow | Submachine 4: The Lab(연구실) 공략 | 59 | |
| 29. | ShifterChaos | Lets Play Submachine Series - The Lab | 58 | |
| 30. |  Indie Horror Games | Submachine 4 : the Lab | 49 | |
| 31. |  Valps Rn | Detonado e História Submachine: O Laboratório #4 | 45 | |
| 32. | 3000josf | [Time] Quick Walkthrough - Submachine 4: The Lab | 40 | Walkthrough |
| 33. | Prongsley | Submachine (Part 9) - Lots of Notes | 40 | |
| 34. | Henry Gerecke | Lucky Song | 39 | |
| 35. |  Fantastic弓長 | 【Submachine】: 4 空間穿越 | The lab(上)〔全字幕〕 | 23 | |
| 36. | ShifterChaos | The Lab Submachine Series - The Labyrinth | 21 | |
| 37. | Simple | submachine 4 | 18 | |
| 38. | Baydock | Submachine 4: The Lab Playthrough | 17 | |
| 39. | Wolfdemon | Submachine: 32 Chambers Walkthrough w/ Wolfdemon | 17 | Walkthrough |
| 40. | Fantastic弓長 | 【Submachine】: 4 作者在實驗室中公開了他的祕密 | The Lab(下) | 15 | |
| 41. | TerribleAtGames - ripped off left and right | Submachine 4: The Lab | 14 | |
| 42. | Theirishmanplays | Thinking With Portal || The Irishman Plays Submachine 4: The Lab Part 2 | 14 | Let's Play |
| 43. | clever and difficult | submachine 4 the lab walkthrough | 12 | |
| 44. | Valps Rn | Offtopic: Submachine 32 Câmaras | 11 | |
| 45. | ShifterChaos | Lets Play Submachine Series - The Laborer | 11 | |
| 46. | Digital Disappointment | Mail-in Mondays - SubMachine 4 (part 2)! | 10 | |
| 47. | Theirishmanplays | Closer to my Goal || The Irishman Plays Submachine 4 The Lab Part 3 | 9 | Let's Play |
| 48. | SubmarineCpt | Submachine 4: The Lab (Regular) in 4:55.41 | 9 | |
| 49. | Theirishmanplays | All Secrets Unfolded || The Irishman Plays Submachine 4: The Lab Part 4 (final) | 9 | Let's Play |
| 50. | Wolfdemon | Somewhere Nearby - Submachine 4: the Lab w/ Wolfdemon | 9 | |
| 51. |  MariachiCZ | Submachine 4: the Lab - walkthrough + all secrets | 9 | Walkthrough |
| 52. | Valps Rn | Locais ocultos em Submachine 4 e 5 | 8 | |
| 53. | Coolshows101 | Submachine 4 P1 | 8 | |
| 54. | Asther | Jeux flash & Co. #9: Submachine 4 | 7 | |
| 55. | Theirishmanplays | I editted something || The Irishman Plays Submachine 4: The Lab Part 1 | 7 | Let's Play |
| 56. | Digital Disappointment | Mail-in Mondays - Submachine 4! (part 1) | 6 | |
| 57. | Luna (Mocha) | Submachine 4 Gameplay+Discussion | 5 | Discussion |
| 58. | xcool group | Submachine 4 The Lab | 5 | |
| 59. | Coolshows101 | Surviv.io 8 | 4 | |
| 60. | Coolshows101 | Maksing for airborne death. Connecting the wall peice and cleaning up the mask. P13 | 3 | |
| 61. | Weird Alexander | Let's play Submachine 4: The Lab, part 1: Science time! | 3 | |
| 62. | Coolshows101 | Submachine 4 P2 | 3 | |
| 63. | Coolshows101 | Submachine 4 P1 | 2 | |
| 64. | IFDF: Broadcast Archive | (VOD Archive) We Continue Deeper Into . . . The Submachine! Submachine Sundays, Part 2! | 1 | |
| 65. | Coolshows101 | Submachine5 P1 | 1 | |
