| 4 days ago |  Dark LORE Dash | The Binding of Isaac Story & Every Ending Explained | 0:00 | 1,620 |
| 2025-07-31 | AdoraVODS | Leaving Isaac in the basement (Binding of Isaac Day 6) - Livestream from 10/07/25 | 0:00 | 6 |
| 2025-07-29 | AdoraVODS | Time to try other characters (Binding of Isaac Day 5) - Livestream from 07/07/25 | 0:00 | 5 |
| 2025-07-25 | CMNO | The Binding of Isaac: I unlocked "the lost" | my first the lost run | 0:00 | 99 |
| 2025-07-24 | CMNO | Delirium could not survive this build! (Full run, no commentary) The Binding of Isaac. | 0:00 | 39 |
| 2025-07-24 | AdoraVODS | The Binding of Isaac wiki is a life saver! - (Binding of Isaac Day 4) - Livestream from 03/07/25 | 0:00 | 4 |
| 2025-07-23 | CMNO | [Seizure Warning⚠ ]The Binding of Isaac: my first time one shotting delirium! | 0:00 | 14 |
| 2025-07-21 | AdoraVODS | How beautiful can we make Isaac look? (Binding of Isaac Day 3) - Livestream from 30/06/25 | 0:00 | 3 |
| 2025-07-17 | AdoraVODS | Further into the unknown (Binding of Isaac Day 2) - Livestream from 26/06/25 | 0:00 | 4 |
| 2025-07-14 | AdoraVODS | In to the basement I go (Binding of Isaac Day 1) - Livestream from 23/06/25 | 0:00 | 2 |
| 2025-07-13 | The Indie Brew | Should we do a backlog let's play series? 🤔 #indiegames #stacklands #bindingofisaac #backlog | 0:00 | 774 |
| 2025-07-13 | CMNO | The Binding of Isaac eve run | 0:00 | 3 |
| 2025-07-12 | CMNO | The Binding of Isaac my first Delirium fight | 0:00 | 20 |
| 2025-07-10 | CMNO | The Binding of Isaac funny angel moment | 0:00 | 80 |
| 2025-06-18 | CMNO | The Binding of Isaac Utero I And Womb II Gameplay. | 0:00 | 2 |
| 2025-06-09 | Game Dev Garnet | Binding of Isaac Style Room Generator in Unity [Full Tutorial] | 0:00 | 965 |
| 2025-05-28 | Casey Joy VA | Binding of Isaac - Respite (w/ humming) | 0:00 | 158 |
| 2025-05-07 | VoltMates | The Worst Game Mode | 0:00 | 37 |
| 2025-05-03 | StablerMarmot7 | Pico vs ??? — INSANE Alley Fight 🔥 [Pico Day 2025 Animation] | 0:00 | 1,112 |
| 2025-05-01 | CMNO | The Binding of Isaac: First time playing blue baby! | 0:00 | 149 |
| 2025-04-30 | StablerMarmot7 | Alley Showdown [Pico Day 2025 Animation] | 0:00 | 419 |
| 2025-04-23 | VoltMates | Rarest Eden Start | 0:00 | 14 |
| 2025-04-21 | Game Dev Garnet | Binding of Isaac Map Generation in Unity! [Map Gen Tutorial] | 0:00 | 3,540 |
| 2025-04-12 | VoltMates | Luckiest Keeper Run | 0:00 | 199 |
| 2025-04-10 | Miss Baka | Moar isaac | 0:00 | 84 |
| 2025-04-05 | VoltMates | Worst keeper Player | 0:00 | 137 |
| 2025-04-01 | StablerMarmot7 | FNF STRESS PICO MIX CUTSCENE! (Pitstop Update 2) #fnf #fridaynightfunkin #fnfpitstopupdate | 0:00 | 2,899 |
| 2025-03-26 | backpackbrain | The Biggest Bone In Isaac. | 0:00 | 12 |
| 2025-03-22 | VoltMates | Tainted Lost Is Painful | 0:00 | 79 |
| 2025-03-21 | backpackbrain | Azazel Beam, The Long Way (The Binding of Isaac) | 0:00 | 30 |
| 2025-03-20 | backpackbrain | Already making my own Pot Plays... (The Binding of Isaac) | 0:00 | 9 |
| 2025-03-19 | backpackbrain | Playing with a dangerous IPECAC (The Binding of Isaac) | 0:00 | 30 |
| 2025-03-18 | backpackbrain | Infinite Bugs on the path to Tainted Blue Baby (The Binding of Isaac) | 0:00 | 19 |
| 2025-03-16 | backpackbrain | The Tainted Maggy Unlock (The Binding of Isaac) | 0:00 | 14 |
| 2025-03-15 | backpackbrain | Unlocking TAINTED ISAAC! (The Binding of Isaac) | 0:00 | 10 |
| 2025-03-14 | backpackbrain | Rewarded for gambing on the D4? (The Binding of Isaac) | 0:00 | 4 |
| 2025-03-13 | backpackbrain | Bending Spoons of Gold (The Binding of Isaac) | 0:00 | 3 |
| 2025-03-12 | backpackbrain | Digging for gold, literally (The Binding of Isaac) | 0:00 | 4 |
| 2025-03-11 | backpackbrain | Trying The Keeper (The Binding of Isaac) | 0:00 | 29 |
| 2025-03-05 | CMNO | The Binding of Isaac Slow Roll Challenge | 0:00 | 7 |
| 2025-03-03 | CMNO | The Binding of Isaac Beating Satan for the first time(ending 12!) | 0:00 | 7 |
| 2025-03-02 | backpackbrain | Nuclear Throne meets The Binding of Isaac...but with MAGIC? (LootMage) | 0:00 | 27 |
| 2025-03-02 | CMNO | The Binding of Isaac Greed mode | 0:00 | 10 |
| 2025-03-01 | CMNO | The Binding of Isaac Head Trauma | 0:00 | 0 |
| 2025-02-28 | CMNO | The Binding of Isaac Guardian Angel | 0:00 | 3 |
| 2025-02-03 | CMNO | The Binding of Isaac waka waka challenge | 0:00 | 21 |
| 2025-01-28 | StablerMarmot7 | Issac collects a cursed item... #shorts #thebindingofisaac #issac #animation | 0:00 | 814 |
| 2025-01-28 | StablerMarmot7 | Issac collects a cursed item | 0:00 | 124 |
| 2025-01-26 | backpackbrain | Reminder to never take Anti-Gravity (The Binding of Isaac) | 0:00 | 15 |
| 2025-01-26 | CMNO | The Binding of Isaac my First Win! | 0:00 | 289 |
| 2024-12-23 | backpackbrain | Pitch Black Challenge first try? (The Binding of Isaac) | 0:00 | 194 |
| 2024-12-22 | backpackbrain | How devilish can these deals really be (The Binding of Isaac) | 0:00 | 11 |
| 2024-12-21 | backpackbrain | DOWN TO THE WIRE AS AZAZEL (The Binding of Isaac) | 0:00 | 22 |
| 2024-12-20 | backpackbrain | EDEN VS ISAAC FIRST TRY (The Binding of Isaac) | 0:00 | 8 |
| 2024-12-20 | backpackbrain | Orbiting glowing orbs (The Binding of Isaac) | 0:00 | 8 |
| 2024-12-18 | backpackbrain | FAMILIARMAXXING AS LILITH (The Binding of Isaac) | 0:00 | 1 |
| 2024-12-17 | backpackbrain | Starting off strong with the beam (The Binding of Isaac) | 0:00 | 13 |
| 2024-11-21 | Mix May [Mashup Channel] | Linkin Park x The Binding of Isaac: No More Sorrow for a Fiendish Foe | 0:00 | 20 |
| 2024-11-05 | Haydex | The Binding of Isaac: Noob's First Blind Run (Complete Beginner Experience) | 0:00 | 647 |
| 2024-09-12 | StablerMarmot7 | FNF LOSE RESULT SCREEN! (Pico Update) #fnf #fridaynightfunkin #fnfupdate #fnfpicoupdate | 0:00 | 319 |
| 2024-08-07 | StablerMarmot7 | FNF Soft Art! #fnf #fridaynightfunkin #fridaynightfunkinart #fnfsoftmod #picoisstillthebest | 0:00 | 60 |
| 2024-08-02 | The Deadly Jedly | Unluckiest Run On This Game #shorts #bindingofisaac | 0:06 | 437 |
| 2024-07-20 | Sklump | I WENT CRAZY ON GREED | 0:22 | 27 |
| 2024-06-07 | Alolan isaac | Most VISIBLE Isaac Run | 16:50 | 12 |
| 2024-05-31 | RealDapper | She Binding on My Isaac Till I REPENTANCE | 47:06 | 19 |
| 2024-05-25 | StablerMarmot7 | Gwimbly - The man himself 🔥🔥🔥 #smilingfriends #gwimbly #gwimblyfanart #newgrounds #eddsworld #short | 0:33 | 267 |
| 2024-05-12 | StablerMarmot7 | Pico Day 2024 Art! 🔥🔥 #pico #picoday #fnf #fridaynightfunkin #shorts | 0:19 | 735 |
| 2024-02-27 | PipeTron | Let's Beat Binding of Isaac Challenges! | 3:04:16 | 2,531 |
| 2024-02-25 | VOD Lime | The Worst Stream In Existence | The Binding Of Pain: Repentance | 4:17:35 | 0 |
| 2024-02-18 | PipeTron | Binding of Isaac But I Have To Do Every Challenge - (LIVE) | 3:36:36 | 3,634 |
| 2024-02-01 | PipeTron | 🔴 26% OF THE WAY THERE | BINDING OF ISAAC | 3:03:43 | 3,278 |
| 2024-01-25 | PipeTron | 🔴 BINDING OF ISAAC CONTINUES... | 4:19:59 | 2,609 |
| 2024-01-19 | allmusicplays | Midnight Dungeon crawling - BINDING OF ISAAC (The bunnys are running around) | 0:00 | 0 |
| 2024-01-18 | allmusicplays | Midnight Dungeon crawling - BINDING OF ISAAC (The bunnys are running around) | 2:25:16 | 19 |
| 2023-11-03 | T-Rex gamer | reacting to the binding of isaac rependence (part 2) | 3:26 | 16 |
| 2023-10-11 | XYCOZIS | Back to Streaming (With A Cat This Time) | 1:00:49 | 13 |
| 2023-09-09 | DocFirebird After Dark - Raw Explicit Uncut | Abyss - 10/09/2023 | 41:51 | 27 |
| 2023-08-21 | DocFirebird After Dark - Raw Explicit Uncut | 'Saac + Clannad - 22/08/2023 | 1:23:42 | 22 |
| 2023-08-20 | DocFirebird After Dark - Raw Explicit Uncut | 'Saac + Clannad - 20/08/2023 | 2:38:41 | 30 |
| 2023-08-19 | DocFirebird After Dark - Raw Explicit Uncut | 'Saac - 20/08/2023 | 1:03:56 | 32 |
| 2023-08-19 | DocFirebird After Dark - Raw Explicit Uncut | 'saac + Clannad - 19/08/2023 | 2:54:12 | 25 |
| 2023-08-18 | DocFirebird After Dark - Raw Explicit Uncut | 'saac + Clannad - 18/08/2023 | 3:34:48 | 49 |
| 2023-08-16 | Step on me, Irene | The Binding Of Isaac - challenge: pong | 57:55 | 140 |
| 2023-08-16 | Mr Blurry Vtuber Ch. | 【The Binding of Isaac】Cry Cry Baby~【MrBlurry | STYGIAN】 | 1:27:06 | 29 |
| 2023-08-05 | Step on me, Irene | The Binding Of Isaac - challenge: backasswards | 37:04 | 179 |
| 2023-07-29 | Step on me, Irene | The Binding Of Isaac - challenge: brains! | 1:08:24 | 83 |
| 2023-07-12 | Step on me, Irene | The Binding Of Isaac - challenge: I rule! | 1:01:58 | 38 |
| 2023-07-12 | Step on me, Irene | The Binding Of Isaac - challenge: pay to play | 59:38 | 48 |
| 2023-07-08 | Step on me, Irene | The Binding Of Isaac - challenge: blue bomber | 48:09 | 55 |
| 2023-06-19 | Step on me, Irene | The Binding Of Isaac - challenge: speed! | 16:02 | 767 |
| 2023-06-17 | Step on me, Irene | The Binding Of Isaac - challenge: the family man | 52:30 | 76 |
| 2023-06-13 | Step on me, Irene | The Binding Of Isaac - challenge: glass cannon | 47:36 | 77 |
| 2023-06-12 | Step on me, Irene | The Binding Of Isaac - challenge: suicide king | 43:38 | 87 |
| 2023-06-12 | Step on me, Irene | The Binding Of Isaac - challenge: demo man | 40:52 | 33 |
| 2023-06-11 | Step on me, Irene | The Binding Of Isaac - challenge: darkness falls | 46:37 | 47 |
| 2023-06-07 | JayKay | baited. | 32:14 | 801 |
| 2023-06-03 | Rookie gameplays | JUEGOS DIFICILES/HARD GAMES #1 - ft. #elxokas | 1:00 | 42 |
| 2023-05-28 | Romeo | I forgot about the Geese and Ducks | 2:18:32 | 11 |
| 2023-05-27 | Zaneq | The binding of Isaac Azazel gameplay | 18:37 | 10 |
| 2023-05-26 | Dream PC | THIS GAME MADE ME QUIT #shorts | 0:51 | 31 |
