| 301. |  Johny_Panda | 5 | 03/ The Binding of Isaac (PC/QC/FR) - Live Twitch | 1:16:31 |
| 302. | Swat954 Gaming | 5 | Binding of Isaac run 1 | 0:00 |
| 303. | Animefan19 | 5 | Die In The Dungeon | 6:29 |
| 304. | PeterTheEvilTediz | 5 | The Binding of Isaac (short Beginings) | 9:35 |
| 305. | Rampage The Sharp | 5 | Devil Killed! | 9:47 |
| 306. | SteamBro | 5 | SteamBro: New Videos (2016-05-30 #135656) | 0:20 |
| 307. | Don Gamer Guy | 5 | The Binding Of Isaac | 54:59 |
| 308. | Sweetlilbee | 5 | Jump into Tears ~ Binding of Isaac Co op #4 | 11:22 |
| 309. | DFuxa Plays | 5 | DFuxa Reviews 7DRL 2023 - Totem of Seeding | 29:12 |
| 310. | AwesomeSuaceable | 4 | professional potato | 4:27:32 |
| 311. | Multi Man | 4 | The Rebrith of The Binding of Issac RB P2 | 37:16 |
| 312. | Game-A-Dayer | 4 | Day 146 - The Binding of Isaac | 50:46 |
| 313. | Niveau Suivant | 4 | The Binding of Isaac avec Prescott - 3 octobre 2017 | 1:54:46 |
| 314. | Biggianf | 4 | The Binding of Isaac - Chill Run | 49:31 |
| 315. | MelodyVictoria | 3 | VOD: Mel finally let us jump down this funny trap door again! || The Binding of Isaac | 0:00 |
| 316. | Funkadeus | 3 | Making a JoJo Mod for The Binding of Isaac - No Experience; First Time Modding | 50:41 |
| 317. | GetTwoBirdsStonedAtOnce | 3 | The Binding of Isaac, whatever is the newest DLC, that's it | 0:00 |
| 318. | zefennekinfan | 3 | Trying The Binding of Isaac Wrath of the Lamb | 35:23 |
| 319. | The Detective on Twitch | 2 | Steam Backlog Series: Binding of Isaac | 10:19 |
| 320. | Morgan Tician | 1 | [Stream Archive] The Binding of Isaac Stream 2 | 3:24:42 |
| 321. | ProPokeNoob Archives | 1 | (July 6/23) Brotato !300 Challenge☀️Recovering from Throat Infection☀️ | 4:24:45 |
| 322. | SuperSentonBomb! | 1 | SuperCreeperBlocks Friday the 13th Stream: Binding of Issac | 45:33 |
| 323. | gordrack | 1 | First dead god grind the binding of Isaac | 1:28:35 |
| 324. | Azimuth Kaos | 1 | Binding of Isaac daily run 01/03/2022 | 51:53 |
| 325. | ForgeWolf G | 1 | Binding of Isaac episode 2 | 21:24 |
| 326. | Mr Baranorn | 1 | Binding of Issac - Day 4 | 2:24:17 |
| 327. | AntoMaster | 1 | Wake up! Stay asleep! | 0:12 |
| 328. | TheRealMichelozzo | 1 | Rebirth Eden Run | 36:07 |
| 329. | Marston Connell | 0 | This Game Is GREAT! | 0:00 |
| 330. | C0mrad3 | 0 | Binding of Isaac Blind Playthrough | 0:00 |
| 331. | BerithVT | 0 | LISA - part 5 | 1:18:36 |
| 332. | JustJosh | 0 | binding of isaac | 0:00 |
| 333. | Kardonis | 0 | Kard plays BoI:R EP 28 - Failure en masse | 22:25 |
| 334. | FirstInLineVODS | 0 | The Binding Of Isaac: Afterbith+ - Part 61 | 1:03:07 |
| 335. | Zercom-Qc | 0 | the binding of isaac je suis nul | 0:00 |
| 336. | THE GHOULERY | 0 | To New Horizons PC Friday Night Frights | 11:55 |
