| 1. |  RiskRim | ONE LAST TIME | Riddle Transfer 2 | 105,540 | |
| 2. | PanitaX | These Are The TOP 5 ITEMS In The Binding Of Isaac Repentance | 78,007 | |
| 3. | PinaCoco | 🍍Innocence Glitched (Basement) - Antibirth - [The Binding of Isaac] - Piano Arrangement/Cover🥥 | 68,469 | |
| 4. | PinaCoco | 🍍Forgotten Lullaby (Secret Room) - Antibirth - [The Binding of Isaac] - Piano Arrangement/Cover🥥 | 66,012 | |
| 5. | Streview | עקידת יצחק - ביקורת - The Binding of Isaac Rebirth - Review - Hebrew | 49,510 | Review |
| 6. | RiskRim | THE END OF THE WORLD | Riddle School 5 | 40,892 | |
| 7. | PinaCoco | 🍍River of Despair (Downpour) - Repentance - [The Binding of Isaac] - Piano Arrangement/Cover🥥 | 40,657 | |
| 8. | RiskRim | Dreamland.exe | 38,300 | |
| 9. | PanitaX | THESE Are The TOP 5 Underrated Items In The Binding Of Isaac Repentance!! | 35,293 | |
| 10. | PanitaX | THESE Are The TOP 5 Devil Deal Items In The Binding Of Isaac Repentance | 33,484 | |
| 11. | PanitaX | How to WIN with Azazel in Isaac | 32,508 | |
| 12. | PinaCoco | 🍍Stargazer (Planetarium) - Repentance - [The Binding of Isaac] - Piano Arrangement/Cover🥥 | 28,841 | |
| 13. | PinaCoco | 🍍Machine in the Walls (Mausoleum) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 26,792 | |
| 14. | RiskRim | THE SATAN VIRUS | Cubicus | 26,783 | |
| 15. | PanitaX | This Isaac Character Turns Every Pickup Into A Gamble!! | 22,035 | |
| 16. | PanitaX | This Isaac Mod Turns You Into a Gunslinger | 20,364 | |
| 17. | PinaCoco | 🍍Home - Repentance - [The Binding of Isaac] - Piano Arrangement/Cover🥥 | 19,974 | |
| 18. | MrAntiFun | The Binding of Isaac Rebirth V1.00 Trainer +4 | 18,949 | |
| 19. | PanitaX | THESE Are The TOP 5 Angel Deal Items In The Binding Of Isaac Repentance | 18,864 | |
| 20. | RiskRim | STRANGER DANGER | Riddle Transfer | 18,768 | |
| 21. | PanitaX | THE BEST Item Combos In The Binding Of Isaac Repentance (Pt1) | 18,670 | |
| 22. | PanitaX | THE BEST Item Combos In The Binding Of Isaac Repentance (Pt2) | 17,688 | |
| 23. | PanitaX | THIS Is How You Unlock The Keeper FAST In The Binding Of Isaac Repentance | 17,404 | |
| 24. | PinaCoco | 🍍Main Theme - [The Binding of Isaac] - Piano Arrangement🥥 | 16,885 | |
| 25. | RiskRim | A SERIAL KILLER | Riddle School 4 | 16,395 | |
| 26. | PinaCoco | 🍍Journey from a Jar to the Sky (Planetarium) -Antibirth- [The Binding of Isaac] - Piano Arrangement🥥 | 14,350 | |
| 27. | RiskRim | HE IS BACK | Return to Riddle School | 14,146 | |
| 28. | GameGems | משחקי אנדרואיד ואייפון פרק 16# - פוקמון, יוגיהו, עקדת יצחק ועוד... | 14,040 | |
| 29. | AquaMark | How to play ONLINE Co-op in Repentance! (Without Remote Play or mods) | 13,079 | Guide |
| 30. | PinaCoco | 🍍Misericorde (Isaac Fight) - Antibirth - [The Binding of Isaac] - Piano Arrangement/Cover🥥 | 12,269 | |
| 31. | PinaCoco | 🍍Allnoise (The Void) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 11,730 | |
| 32. | PanitaX | The EXPLOSIVE Tainted Lost Run | 11,216 | |
| 33. | PinaCoco | 🍍Foreigner in Zeal (Flooded Caves) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 11,151 | |
| 34. | PinaCoco | 🍍Gloria Filio (Mom's Heart) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 10,346 | |
| 35. | PinaCoco | 🍍Greed - Flash Ver. - [The Binding of Isaac] - Piano Arrangement🥥 | 9,971 | |
| 36. | PinaCoco | 🍍Sacrificial - 10th Anniversary - [The Binding of Isaac] - Piano Arrangement/Cover🥥 | 9,845 | |
| 37. | PinaCoco | 🍍The Calm - Rebirth - [The Binding of Isaac] - Piano Arrangement🥥 | 8,856 | |
| 38. | PanitaX | The "Let Me Cook Run"!!! | 8,805 | |
| 39. | PanitaX | 3 Tips EVERY Isaac Player Needs To Know! | 8,776 | |
| 40. | PinaCoco | 🍍Descent (Title) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 8,725 | |
| 41. | PinaCoco | 🍍Depression Shop - Antibirth - [The Binding of Isaac] - Piano Arrangement/Cover🥥 | 8,521 | |
| 42. | PanitaX | This is how you break Tainted Kepeer | 8,283 | |
| 43. | ToLy | עקדת יצחק - פרק 65 [בטעות עלה לערוץ הזה] | 7,791 | |
| 44. | Yuko Yurei Ch. idol-EN | 【BINDING OF ISAAC】why are we sobbing 😭 | 7,541 | |
| 45. | PanitaX | How to win EVERY RUN As Blue Baby! | 7,256 | |
| 46. | PinaCoco | 🍍Morphine (Dark Room) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 6,811 | |
| 47. | PanitaX | The MOST PAINFUL Isaac Moment #gaming #repentance #games #gamble #luckiest #thebindingofisaac | 6,612 | |
| 48. | PanitaX | 3 Must-Have Mods for Binding of Isaac Players | 6,315 | |
| 49. | PinaCoco | 🍍The Thief (Cathedral) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 6,240 | |
| 50. | PinaCoco | 🍍Outside the Fold (Cellar) - Antibirth - [The Binding of Isaac] - Piano Arrangement/Cover🥥 | 6,153 | |
| 51. | PinaCoco | 🍍Esc (Arcade) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 5,782 | |
| 52. | PanitaX | How To WIN As Tainted Keeper In The Binding Of Isaac!! | 5,778 | |
| 53. | PanitaX | Every item is mystery gift #repentance #gaming #god #luckiest #games #gamble #brimstone | 5,520 | |
| 54. | PinaCoco | 🍍Flashpoint (Burning Basement) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 5,439 | |
| 55. | PanitaX | I unlocked the BEST character in the binding of isaac | 5,367 | |
| 56. | Adam Bachar | Illidan Stormrage Slark Ranked Gameplay | 5,141 | |
| 57. | PinaCoco | 🍍Non Funkible Token (Ultra Greed) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 5,072 | |
| 58. | PinaCoco | 🍍Tome of Knowledge (Library) - Rebirth - [The Binding of Isaac] - Piano Arrangement🥥 | 5,006 | |
| 59. | PinaCoco | 🍍Intro (Cinematic) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 4,842 | |
| 60. | PinaCoco | 🍍Serenity (Super Secret Room) - Flash Ver. - [The Binding of Isaac] - Piano Arrangement🥥 | 4,617 | |
| 61. | PanitaX | spirit sword synergy's!! | 4,523 | |
| 62. | PanitaX | The actual Sacred Heart laser beam | 4,413 | |
| 63. | PanitaX | This New Item Gives You UNLIMITED TEARS! | 4,353 | |
| 64. | PinaCoco | 🍍Sepulcrum - Afterbirth+ - [The Binding of Isaac] - Piano Arrangement🥥 | 4,237 | |
| 65. | PanitaX | How To WIN As The Lost In The Binding Of Isaac!! | 4,200 | |
| 66. | PlayStation Israel | חמשת המשחקים הקשים והמאתגרים ביותר!!! | 4,152 | |
| 67. | PinaCoco | 🍍Respite - Flash Ver. - [The Binding of Isaac] - Piano Arrangement🥥 | 3,928 | |
| 68. | PinaCoco | 🍍Lucidate (Library) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 3,602 | |
| 69. | PanitaX | Laz Is OFFICIALLY BROKEN #gaming #repentance #games #gamble #luckiest #thebindingofisaac #twitch | 3,599 | |
| 70. | PinaCoco | 🍍Whitepath (Angel Room) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 3,192 | |
| 71. | PanitaX | Least broken Tainted Keeper run be like | 3,184 | |
| 72. | PanitaX | The best Tainted Isaac run of 2023 | 3,184 | |
| 73. | PinaCoco | 🍍Marble Forest (Catacombs) - Antibirth - [The Binding of Isaac] - Piano Arrangement🥥 | 3,142 | |
| 74. | PanitaX | THIS is how YOU should play Azazel | 2,674 | |
| 75. | RiskRim | This Is Not a Bug | Antadin (Ending) | 2,662 | |
| 76. | PanitaX | Every Item Is Bob's Brain #gaming #repentance #games #gamble #luckiest #thebindingofisaac #twitch | 2,563 | |
| 77. | PanitaX | Lost Damocles is an INSTAWIN | 2,548 | |
| 78. | PanitaX | You can NEVER GO WRONG with THIS SYNRGY | 2,531 | |
| 79. | PanitaX | Mei - The most fun modded character (The binding of Isaac mod showcase) | 2,467 | Show |
| 80. | PanitaX | THIS is how you break Tainted Kepeer | 2,433 | |
| 81. | PanitaX | This Character Got AN ACTUAL GUN | 2,402 | |
| 82. | PanitaX | I Got The PERFECT SOY MILK RUN | 2,387 | |
| 83. | PanitaX | This New Character Got UNLIMITED LUCK | 2,352 | |
| 84. | PanitaX | I Got THE DOGMA BRIMSTONE | 2,327 | |
| 85. | PanitaX | I Got The PERFECT Tainted Lost Run! | 2,246 | |
| 86. | PanitaX | THIS is how you ACTUALLY BREAK The Lost in the binding of Isaac | 2,235 | |
| 87. | PanitaX | Tainted Lost Damocles Is INSANE | 2,224 | |
| 88. | PanitaX | I Got THE PERFECT EXPLOSIVE SYNERGY In The Binding Of Isaac | 2,222 | |
| 89. | PanitaX | The binding of Isaac but enemies DROP ITEMS | 2,222 | |
| 90. | PanitaX | Spindown Dice Is OFFICIALLY BROKEN | 2,206 | |
| 91. | PanitaX | Finding A Damocles Mid Run Be Like: | 2,200 | |
| 92. | PanitaX | This character can NEVER get a bad run | 2,184 | |
| 93. | PanitaX | I Got The PERFECT Brimstone Run | 2,180 | |
| 94. | PanitaX | I Got The PERFECT 20/20 SYNERGY | 2,164 | |
| 95. | PanitaX | I Got The Most SATISFYING Tech X Run | 2,145 | |
| 96. | PanitaX | Damocles Lost Is An INSTAWIN | 2,134 | |
| 97. | PanitaX | How To Win EVERY RUN As Tainted Lost | 2,122 | |
| 98. | PanitaX | My Chat Did NOT Believe This Tainted Keeper Run | 2,071 | |
| 99. | PanitaX | I Got The PERFECT TAINTED KEEPER RUN | 2,066 | |
| 100. | PanitaX | ALWAYS Play Your Sacrifice room kids | 2,052 | |
