| 1. |  People Vs Food | ELDERS READ TWENTY ONE PILOTS' HIT SONGS (React) | 11,527 | |
| 2. | MTV | Twenty One Pilots Perform Shy Away, Heathens & More | MTV Unplugged | 4,133 | |
| 3. | The Ukulele Teacher | The Judge - Twenty One Pilots (Ukulele Tutorial) | 2,210 | Tutorial |
| 4. | The World Explained | 17 Fastest Twenty One Pilots Raps | 2,026 | |
| 5. | ItsTrain | Overwatch Gun Sync - Twenty One Pilots - Stressed Out (Tomsize Remix) | 1,563 | |
| 6. | Jared Halley | Twenty One Pilots (ACAPELLA Medley) - Stressed Out, Heathens, Ride, Chlorine and MORE! | 1,418 | |
| 7. | SNARLED | Drawing Twenty One Pilots // Rad Portraits with Beth Be Rad | Snarled | 1,321 | |
| 8. | The Ukulele Teacher | We Don't Believe What's On TV - Twenty One Pilots (Ukulele Tutorial) | 1,142 | Tutorial |
| 9. | Bogdan | twenty one pilots: Jumpsuit [Official Video] Реакция | twenty one pilots | Реакция на Jumpsuit | 974 | |
| 10. | Elise Ecklund | My top 7 favorite twenty one pilots songs! | 859 | |
| 11. | The World Explained | Top 10 Best Twenty One Pilots Songs REACTION!!! | 774 | |
| 12. | Jared Halley | Twenty One Pilots - Tear In My Heart (ACAPELLA) on Spotify & Apple | 761 | |
| 13. | Bass Boosted | twenty one pilots - Heathens (DISTO Remix) [Bass Boosted] | 740 | |
| 14. | Knox Hill | Rapper Reacts to TWENTY ONE PILOTS!! | HEAVYDIRTYSOUL (FIRST EVER REACTION) | 618 | |
| 15. | The World Explained | IF YOU SING, YOU LOSE! (TWENTY ONE PILOTS) | 609 | |
| 16. | Bass Boosted | twenty one pilots - Ride (Jaydon Lewis Remix) [Bass Boosted] | 576 | |
| 17. | MTV | Twenty One Pilots Perform “Stressed Out” | MTV Unplugged | 536 | |
| 18. | Alex Hefner | twenty one pilots - "Level of Concern" (Official Video) | REACTION | 501 | |
| 19. | Knox Hill | Rapper Reacts to TWENTY ONE PILOTS LIVE! | LANE BOY & MORE (THE JOURNEY BEGINS) | 480 | |
| 20. | The Ukulele Teacher | Nico And The Niners - Twenty One Pilots (Ukulele Tutorial) | 428 | Tutorial |
| 21. | MTV | Twenty One Pilots Perform “Car Radio/Heathens” | MTV Unplugged | 373 | |
| 22. | The Ukulele Teacher | Time Adventure (Rebecca Sugar Adventure Time) Ukulele Tutorial | 370 | Tutorial |
| 23. | Elise Ecklund | Ride - twenty one pilots | EASY UKULELE TUTORIAL | 369 | Tutorial |
| 24. | Alex Hefner | FIRST TIME hearing twenty one pilots!!! : Lane Boy REACTION | 356 | |
| 25. | Zeepsterd | In Defense of Twenty One Pilots and Scaled and Icy | 354 | |
| 26. | The Ukulele Teacher | My Blood - Twenty One Pilots (Easy Ukulele Tutorial) | 301 | Tutorial |
| 27. | Alex Hefner | Metalhead Reacts to twenty one pilots - "Christmas Saves The Year" (REACTION) | 299 | |
| 28. | NearlySeniorCitizen Yetagamer | Kitchen Sink - twenty one pilots [lyrics] : Bankrupt Creativity #684 - My Reaction Videos | 281 | |
| 29. | NearlySeniorCitizen Yetagamer | TWENTY ONE PILOTS - HEAVYDIRTYSOUL : Bankrupt Creativity #420 - My Reaction Videos | 281 | |
| 30. | Knox Hill | Rapper Reacts to TWENTY ONE PILOTS - JUMPSUIT FOR THE FIRST TIME!! | THE SYMBOLISM IS CRAZY | 280 | |
| 31. | The Ukulele Teacher | Jumpsuit - Twenty One Pilots (Ukulele Tutorial) | 272 | Tutorial |
| 32. | Elise Ecklund | Doubt - Twenty One Pilots (Acoustic Cover) | 269 | |
| 33. | Crown Family | FIRST TIME HEARING - twenty one pilots: Car Radio [OFFICIAL VIDEO] - REACTION | 259 | |
| 34. | NearlySeniorCitizen Yetagamer | twenty one pilots - Truce : Bankrupt Creativity #592 - My Reaction Videos | 208 | |
| 35. | The Ukulele Teacher | House Of Gold - Twenty One Pilots (SPOONS TUTORIAL) | 195 | Tutorial |
| 36. | NearlySeniorCitizen Yetagamer | TWENTY ONE PILOTS - LANE BOY : Bankrupt Creativity #436 - My Reaction Videos | 185 | |
| 37. | NearlySeniorCitizen Yetagamer | TWENTY ONE PILOTS - GUNS FOR HANDS : Bankrupt Creativity #376 - My Reaction Videos | 184 | |
| 38. | iamsickflowz | twenty one pilots: Heavydirtysoul (Live at Fox Theater) REACTION!! | iamsickflowz | 173 | |
| 39. | iamsickflowz | Twenty One Pilots - Oh, Ms Believer (Lyrics video) REACTION!! | iamsickflowz | 167 | |
| 40. | MVPerry | FRUIT JUICE - "Jumpsuit" Twenty One Pilots PARODY (TOP Parody) | 162 | |
| 41. | Dev Lethal | Another AMAZING Song! // Twenty One Pilots: Migraine Reaction | 146 | |
| 42. | Crown Family | FIRST TIME HEARING - twenty one pilots: Heavydirtysoul [OFFICIAL VIDEO] - REACTION | 142 | |
| 43. | Blackheart Music | Twenty One Pilots Cover Remix - Heathens【GMV】 | 138 | |
| 44. | iamsickflowz | twenty one pilots: Holding On To You [OFFICIAL VIDEO] REACTION!! | iamsickflowz | 138 | |
| 45. | iamsickflowz | twenty one pilots: Car Radio [OFFICIAL VIDEO] REACTION!! | iamsickflowz | 133 | |
| 46. | The Matthews Fam | [ REACTION ] Twenty one pilots - Chlorine (Official Video) | 131 | |
| 47. | NearlySeniorCitizen Yetagamer | ODE TO SLEEP - TWENTY ONE PILOTS : Bankrupt Creativity #357 - My Reaction Videos | 130 | |
| 48. | Elise Ecklund | TWENTY ONE PILOTS LIVE - CONCERT EXPERIENCE | 130 | |
| 49. | Dev Lethal | This Was SUPER DOPE! // Twenty One Pilots: Car Radio [OFFICIAL VIDEO] Reaction | 130 | |
| 50. | Knox Hill | CRAZY RAP FLOWS!! | Rapper Reacts to TWENTY ONE PILOTS - OVERCOMPENSATE (First Reaction) | 117 | |
| 51. | MTV | The Ultimate Twenty One Pilots Fan Showdown | Stan vs. Stan | 112 | Show |
| 52. | Elise Ecklund | SISTERS REACTING TO HOLDING ON TO YOU BY TWENTY ONE PILOTS | 106 | |
| 53. | SuperJersh | Twenty One Pilots Level of Concern Reaction! - Jersh Reacts | 104 | |
| 54. | Crown Family | twenty one pilots: Stressed Out [OFFICIAL VIDEO] - REACTION - FIRST TIME HEARING | 95 | |
| 55. | Nick Forell | FIRST Time Ever Hearing Twenty One Pilots - "Lane Boy" REACTION | 95 | |
| 56. | Nick Forell | FIRST Reaction - Car Radio - Twenty One Pilots | 93 | |
| 57. | iamsickflowz | 🎤 Hip-Hop Fan Reacts To twenty one pilots - Jumpsuit 🎸 | iamsickflowz | 89 | |
| 58. | iamsickflowz | Twenty One Pilots - Screen REACTION!! | iamsickflowz | 83 | |
| 59. | Wolf Reacts TV | FIRST TIME LISTENER!!! | twenty one pilots: Stressed Out [OFFICIAL VIDEO] | BEST REACTION!!! | 69 | |
| 60. | Crown Family | twenty one pilots: Lane Boy [OFFICIAL VIDEO] - REACTION - FIRST TIME HEARING | 69 | |
| 61. | Wolf Reacts TV | I MUST GO!!! | twenty one pilots: Trees + Speech (Live at Fox Theater) | BEST REACTION!!! | 69 | |
| 62. | Mikey and Bob | Kidz Bop 33 - Twenty One Pilots - Ride | 68 | |
| 63. | iamsickflowz | Twenty One Pilots - Lane Boy (Live In Bonnaroo 2015) REACTION!! | iamsickflowz | 67 | |
| 64. | Reactions by D | Pentatonix cover 'Ride' by Twenty One Pilots - REACTION - Flawless.... | 66 | |
| 65. | TruPara | twenty one pilots: Holding On To You (Reaction) | 59 | |
| 66. | Wolf Reacts TV | SECOND TIME LISTENER!! | twenty one pilots: Guns For Hands [OFFICIAL VIDEO] | BEST REACTION!!! | 57 | |
| 67. | DisfunktionalTV | Twenty One Pilots - Car Radio REACTION | 56 | |
| 68. | Wolf Reacts TV | NEW FAN | twenty one pilots: Lane Boy [OFFICIAL VIDEO] | BEST REACTION!!! | 56 | |
| 69. | The Ukulele Teacher | Twenty One Pilots Songwriting Contest Winner #1! | 54 | |
| 70. | TruPara | Twenty One Pilots Migraine [Reaction] | 53 | |
| 71. | TruPara | twenty one pilots - Trees (Live) [Reaction] | 50 | |
| 72. | NearlySeniorCitizen Yetagamer | Koi no Hime Hime Pettanko : My Reaction Videos # One Thousand Four Hundred & Twenty One! | 50 | |
| 73. | TruPara | twenty one pilots: Car Radio [Reaction] | 49 | |
| 74. | NicTrix | This Is So SAD... | The Craving REACTION - Twenty One Pilots | 48 | |
| 75. | iamsickflowz | twenty one pilots: Heavydirtysoul [OFFICIAL VIDEO] REACTION!!! | iamsickflowz | 48 | |
| 76. | TruPara | twenty one pilots: Ode To Sleep [Reaction] "THIS IS TRUE INSPIRATION!" | 44 | |
| 77. | Wolf Reacts TV | NEVER DISAPPOINTS! | twenty one pilots - "Migraine" captured in The Live Room | BEST REACTION!!! | 43 | |
| 78. | iamsickflowz | Twenty One Pilots: Forest (Live at Newport Music Hall) REACTION!! | iamsickflowz | 43 | |
| 79. | Crown Family | twenty one pilots - Pet Cheetah (Official Audio) - REACTION - FIRST TIME HEARING | 42 | |
| 80. | The Ukulele Teacher | Oh Ms Believer - Twenty One Pilots - Ukulele Cover | 42 | |
| 81. | Wolf Reacts TV | REALLY DEEP! | twenty one pilots: Car Radio [OFFICIAL VIDEO] | BEST REACTION!!! | 42 | |
| 82. | TrueGawd | Hip-Hop Head's FIRST TIME Hearing "Jumpsuit" by Twenty One Pilots (Official Music Video) | 40 | |
| 83. | TrueGawd | HAVE MERCY!| twenty one pilots: Nico And The Niners [Official Video] | REACTION | 39 | |
| 84. | iamsickflowz | 🔥🎵 REACTION!! 🎵🔥 twenty one pilots: Stressed Out [OFFICIAL VIDEO] | iamsickflowz | 38 | |
| 85. | Mugnify Reacts | First Reaction To Twenty One Pilots "Stressed Out" | 38 | |
| 86. | BrittReacts | FIRST TIME REACTING TO | "Lane Boy" featuring Mutemath Live - Twenty One Pilots | 37 | |
| 87. | iamsickflowz | twenty one pilots: Ride REACTION!! | iamsickflowz | 37 | |
| 88. | Girlcatlove1524 | Level of Concern Drum Cover By Twenty One Pilots (FREE SHEET MUSIC) | Girlcatlove1524 | 36 | |
| 89. | TruPara | twenty one pilots - Polarize [Reaction] | 34 | |
| 90. | Z.L. Entertainment | Reaction! | Twenty One Pilots - Migraine (The Live Room) | 34 | |
| 91. | Wolf Reacts TV | THEY CAN RELATE!! | twenty one pilots: Fairly Local [OFFICIAL VIDEO] | BEST REACTION!!! | 33 | |
| 92. | Send1t | 1st Time Hearing This! Twenty One Pilots First Reaction | Elvis Cover | 33 | Let's Play |
| 93. | Crown Family | twenty one pilots: Heathens (from Suicide Squad: The Album) - REACTION - FIRST TIME HEARING | 32 | |
| 94. | Wolf Reacts TV | HIS FLOWW!! | twenty one pilots - Pet Cheetah | BEST REACTION!!! | 32 | |
| 95. | Brian - LCS | Breakfast with Brian Episode Twenty One | 32 | Show |
| 96. | RMSHN | Реакция музыканта на Shy Away - Twenty One Pilots | Вашу Юру! | 31 | |
| 97. | DisfunktionalTV | twenty one pilots: House of Gold REACTION | THIS HIT HOME!!! | 30 | |
| 98. | SHADOW LEGION ENTERTAINMENT | Twenty one Pilots Chlorine Official Audio -REACTION- | 29 | |
| 99. | Crown Family | twenty one pilots - Chlorine (Official Video) - REACTION - FIRST TIME HEARING | 29 | |
| 100. | Wolf Reacts TV | SOO CATCHY!! | twenty one pilots: Heavydirtysoul | BEST REACTION!!! | 28 | |
