Game:

The Binding of Isaac: Rebirth (2014)

Duration: 1:38

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1

This synergy: Tammys' head, Chocolate milk, Deaths Touch, Mulligan, Interdimensional baby and incubus.

Charging a chocolate milk shot before using Tammys' head makes the shots exponential larger and more powerful then if it was uncharged.
The Mulligan has a 1/6 change to spawn a fly every time you hurt an enemy with tears, flys attack enemies for 2.5X your current damage, incubus shoots your tears, so it effectively doubles my normal damage output, Interdimensional baby increases the damage of any tear that passes through it, doubles them and turns them into a blinking orb, because my shots are so big their hitbox passes through IDB no matter where i am.

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