Rationale Design of new Drugs Using Azure
0Using computers instead of conventional wet chemical synthesis and biological assay of molecular drug candidate saves both time and money in the long (~10 years) and expensive (~$1 billion) process of new drug development. TeraDiscoveries leverages the power of Azure to develop and deploy scientific software for the analysis, modeling and simulation of quantitatively intense life sciences and drug discovery computing problems. The hallmark of TeraDiscoveries' drug discovery platform is the Inverse Design system, our successful research through Duke University in chemo-informatics. We have combined the best of breed algorithms that resulted from this research with Azure to provide a blazingly fast, highly accurate drug discovery platform. Beginning with the X-ray structure of a target, the Inverse Design platform can identify novel leads, peptides or biologics as a virtual screening step, and the first step in drug discovery after target validation. Further, Inverse design can optimize an existing lead to produce a better binding lead, or a proprietary new lead.