Red Dead Redemption: Undead Nightmare - Mission #8 - On a Pale Horse - Ending and Epilogue
In the eighth and final mission of Red Dead Redemption: Undead Nightmare, having finally ended the undead plague after returning Ayauhtéotl's Mask to its rightful place in the Escalera Catacombs, John Marston returns to and re-opens his ranch house at Beecher's Hope, where he finds Abigail and Jack still hogtied, but are no longer suffering the effects of the undead plague. The family embraces as the nightmare appears to be over.
However, three months later, Seth Briars is seen stealing Ayauhtéotl's Mask from the Escalera Catacombs, an action that apparently takes place sometime after the events of the final mission in Red Dead Redemption, "The Last Enemy That Shall Be Destroyed", because it also causes John to rise from his grave as well. Despite this, he does not become a mindless flesh-eater, and still retains his soul and core functions, but with the physical appearance of a cannibalistic corpse.
According to the in-game message:
"Marston was buried by his wife and son with a flask of water he seemed to treasure. They did not know of its special power. Now, he comes back to this earth with the body of an undead wretch, but the soul of a man. Help put him to rest by finishing his work on earth."
Unless the player still has some game elements incomplete (such as ambient challenges or Missing Souls missions) there does not appear to be any other mission upon which Marston can embark that will 'put him to rest'. Seth and the Mask are nowhere to be found and the entrance to the catacombs has closed. Towns will still fall victim to undead outbreaks, but the outcome will be the same as when the player completed these tasks before this last mission.
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