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"Resident Evil Zero was first unveiled during the Tokyo Game Show in 2000. The game was originally slated for the Nintendo 64, as it was believed by the developers that the platform's cartridge-based media would be more capable in handling the item dropping and partner zapping systems proposed for the game than the disc-based media used by the Sony PlayStation and Sega Dreamcast due to the lack of loading times. However, production of the game shifted from the Nintendo 64 to the GameCube as a result of the transition to sixth generation consoles. Since the GameCube made use of a disc-based media, the programmers were forced to rely on clever programming methods to shorten the loading times. The graphics were improved dramatically due to the platform change.

In contrast to other known Resident Evil prototypes, which have been known to go through massive changes during production, the story and settings remained mostly unchanged in the released version. Rebecca's original character design featured her wearing a beret instead of the red bandanna she wears in the original game. In the released GameCube version, she uses the same design from the previously released GameCube remake of Resident Evil.

Currently, this is the only Resident Evil in the main lineage not to be released on multiple platforms. Though a run through of it can be played in Resident Evil: The Umbrella Chronicles.

Originally Resident Evil Zero was supposed to lay the groundwork for the Progenitor Virus, which was to be the viral agent in Resident Evil 4 before the game was radically changed and the story re-written from scratch." - wikipedia