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Sickle-cell anemia is an autosome linked recessive trait that can be transmitted from parents to the offspring when both the partners are carrier for all the gene (or heterozygous). The disease is controlled by a single pair of allele, \( \mathrm{Hb}^{\mathrm{A}} \) and \( \mathrm{Hb}^{\mathrm{s}} \). Out of the three possible genotypes only homozygous individuals for \( \mathrm{HbS}\left(\mathrm{Hb}^{\mathrm{S}} \mathrm{Hb}^{\mathrm{S}}\right) \) are lethal. Identify \( \mathrm{X}, \mathrm{Y} \) and Z.
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Normal Hb (A) Gene
Sickle-cell Hb(S) Gene
...X...
(1) X - CAC; Y - GTG ; Z - Val
(2) X-CAC; Y - GTG; Z - Phe
(3) X - GTG; Y - CAC; Z - Val
(4) X - CAC; Y - GTG; Z - His
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