Duration: 2:18:36

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💊 Order Sigma Here: https://gorillamind.com/products/sigma?rfsn=4539799.ade75a
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📌 Table Of Contents:
• [0:00] – Sigma introduction and my issue with many Testosterone boosting compounds
• [2:35] – 300-400 ng/dL Total Testosterone increases. The Joe Rogan podcast episode that piqued my interest with Andrew Huberman
• [5:40] – My initial impression of Tongkat Ali and SERMs for boosting Testosterone levels
• [8:12] – The ambiguity of the mechanism of action of Tongkat Ali and Fadogia Agrestis
• [9:32] – Andrew Huberman and I discuss each Testosterone boosting supplement he found to be effective
• [34:39] – Sigma Ingredients Breakdown – 2 capsules/4 capsules
○ [38:04] – Magnesium Bisglycinate – 100 mg/200 mg
∙ [38:12] – The different formats of Magnesium
∙ [40:03] – The different formats of Zinc
∙ [41:01] – Effects of Magnesium supplementation on Testosterone levels
○ [43:03] – Zinc Bisglycinate – 15 mg/30 mg
∙ [43:09] – Effects of Zinc on Testosterone synthesis
∙ [44:11] – Zinc status and serum Testosterone levels of healthy adults
○ [45:11] – Vitamin D3 – 1500 IU/3000 IU
∙ [45:14] – Why so many people are deficient in Vitamin D
∙ [45:24] – My blood test results
∙ [45:44] – The importance of adequate Vitamin D levels
∙ [46:53] – Testicular synthesis and Vitamin D action
∙ [47:47] – Effect of Vitamin D supplementation on Testosterone levels
∙ [48:39] – Association of Vitamin D status with serum androgen levels
∙ [50:38] – Best sources of dietary Vitamin D
○ [52:46] Fadogia Agrestis Extract 10:1 – 300 mg/600 mg
∙ [52:46] – The Fadogia Agrestis hype
∙ [54:58] – Why Sigma featured the dosage breakdown it does at 1-4 capsules, companies putting 600 mg in 1 capsule and forcing you to cross your fingers
∙ [56:46] – The speculated mechanism of action
∙ [59:52] – How to cycle “Sigma” and most responsibly use it
∙ [1:00:40] – Fadogia Agrestis human equivalent dosage breakdown
∙ [1:02:28] – Why you should track your biomarkers and fertility parameters and who “Sigma” is best suited for
∙ [1:05:00] – 2-6 fold increases in Testosterone levels in male albino rats
∙ [1:07:37] – Suggested mechanism of action
∙ [1:14:20] – Testicular toxicity in male albino rats
∙ [1:17:00] – Liver and kidney toxicity metrics
∙ [1:17:59] – Fadogia cycle length in the efficacy study vs. the side effects study
∙ [1:19:35] – The utility of natural supplements in comparison to exogenous hormone use
∙ [1:20:54] – Fadogia cycle length (continued), lowest effective dose with responsible titration if warranted, and Andrew Huberman’s disclaimer on tracking your data
∙ [1:24:04] – Testicular toxicity data with Tamoxifen/Nolvadex, Clomid and HCG and what happens at high enough doses in anything pro-fertility | Fadogia Agrestis efficacy relative to side effect profile
∙ [1:37:06] – Who are the best candidates for taking “Sigma” and things to consider before you use it
○ [1:42:21] – Tongkat Ali 200:1 (Indonesian origin) – 200 mg/400 mg
∙ [1:42:21] – Mechanism of action
∙ [1:46:13] – The standardization and country of origin of our Tongkat Ali
∙ [1:46:49] – Randomized 12 week clinical trial
∙ [1:47:51] – Tongkat Ali dosages
∙ [1:48:55] – Tongkat Ali in managing idiopathic male infertility
∙ [1:50:15] – Tongkat Ali as testosterone booster for managing men with late-onset hypogonadism?
∙ [1:53:21] – The effect of Tongkat Ali on the regulation of reproductive hormones in young men
∙ [1:54:38] – Further insight into Tongkat Ali’s mechanism(s) of action
∙ [1:57:23] – The effect of Tongkat Ali on the regulation of reproductive hormones in young men study continued
∙ [1:58:48] – Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects
○ [1:59:42] – Ashwagandha (standardized to 5% total withanolides) – 150 mg/300 mg
∙ [1:59:42] – Ashwagandha mechanism of action, dosage and cycle duration
∙ [2:01:16] – Ashwagandha effect on semen quality in stress-related male fertility
∙ [2:03:00] – An investigation into the stress-relieving and pharmacological actions of Ashwagandha Extract
∙ [2:05:08] – Examining the effect of Ashwagandha supplementation on muscle strength, size, recovery, and Testosterone production
∙ [2:07:28] – Effects of Ashwagandha on Reproductive System: A Systematic Review of the Available Evidence
∙ [2:08:20] – Responsible use of Ashwagandha and other Testosterone boosting supplements
○ [2:09:00] – Boron 3 mg/6 mg
∙ [2:09:10] – Boron mechanism of action and utility for increasing Free Testosterone levels
∙ [2:11:21] – Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines
• [2:15:48] – Conclusion – What to expect from Sigma and who this product is best suited for