Pretty much just have to check the info cards of the system you're in and the one you're going to; make sure to not bring export goods of the destination system (so, the disjoint set by comparison essentially).
If space pirates do their usual ordeal, it's B to drop the cargo pods before the space battle, and G to get them again afterwards.
In the trade menu, the green bars are supply and usually lower supply means higher demand, & vice versa, within that particular station. If you're making multiple runs, it would be useful to pay attention to how the items you sell increase supply and thereby lower demand (probably best to switch it up each round.)
Early on, it might also be good to get afterburners upgraded if you wish to outrun pirates and hyperjump like Moya in FarScape (or get within the realm of the space police faster after jumping in from the stargate's zone, which you'd think should be guarded better...)
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