Which of the following can bring about the denaturation of proteins? (A) Exposure to salts of he...

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Which of the following can bring about the denaturation of proteins?
(A) Exposure to salts of heavy metal ions
(B) Exposure to acid and bases
(C) Exposure to temperature below \( -5^{\circ} \mathrm{C} \)
(D) All of the above
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