Which of the following statements about mutation are true? (I) Muta...

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Which of the following statements about mutation are true?
(I) Mutations are the source of new alleles of genes.
(II) Organisms are able to create mutations to meet their specific needs.
(III) Mutations are random events and can happen in any cell at any time.
(IV) Most mutations tend to be harmful or have no effect on an organism.
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