Which of the followings can bring about the denaturation of protein...

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Which of the followings can bring about the denaturation of proteins?
I. Reaction to salts of heavy metals
\( \mathrm{P} \)
II. Reaction to acid and bases
III. Reaction to inorganic neutral salts
W
IV. Preservation at a temperature below \( -5^{\circ} \mathrm{C} \)
(a) I and IV are correct
(b) II and IV are correct
(c) I, II and III are correct
(d) III and IV are correct
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