Top 100 The Binding of Isaac Videos With The Most Comments by PaperBatVGTop 100 » 200 » 300 » 400 » 500Video TitleCommentsCategoryGame1.This Is The Run: The Binding of Isaac - The Game Hates Me (Run #2)456The Binding of Isaac 2.This Is The Run: The Binding of Isaac - Stacking Iron (Run #1)429The Binding of Isaac 3.Prove Yourself: The Real Purist - The Binding of Isaac (Pilot Episode)382ShowThe Binding of Isaac 4.This Is The Run: The Binding of Isaac - Smartie Strat (Run #3)378The Binding of Isaac 5.Prove Yourself: The Real Purist Winner - kralaland141The Binding of Isaac Top 100 » 200 » 300 » 400 » 500