| 1. | the isaac BACKWARDS challenge | 19,764 | Let's Play | The Binding of Isaac: Rebirth
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| 2. | UNLOCKING THE FORGOTTEN! (Binding Of Isaac) | 18,760 | Let's Play | The Binding of Isaac: Rebirth
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| 3. | EPIC RUN AS THE FORGOTTEN! (Binding Of Isaac) | 18,394 | Let's Play | The Binding of Isaac: Rebirth
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| 4. | OMG I FINALLY SAW NEW ISAAC STUFF!!!1! | 12,899 | | The Binding of Isaac: Rebirth
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| 5. | APOLLYON VS ULTRA GREEDIER (binding of isaac) | 12,760 | Let's Play | The Binding of Isaac: Rebirth
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| 6. | ok but apollyon is kinda great (binding of isaac) | 12,510 | Let's Play | The Binding of Isaac: Rebirth
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| 7. | isaac finds his long lost family! (adorable) | 11,292 | Let's Play | The Binding of Isaac: Rebirth
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| 8. | most satisfying isaac run ever | 10,651 | Let's Play | The Binding of Isaac: Rebirth
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| 9. | BUMBO IS INSANE (Binding Of Isaac) | 10,095 | Let's Play | The Binding of Isaac: Rebirth
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| 10. | ISAAC - I beat delirium without touching my controller lol | 9,930 | Let's Play | The Binding of Isaac: Rebirth
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| 11. | THE NEW ISAAC GAME IS OUT AKSLJDHFLAKSJDHFLKAS | 9,752 | Let's Play | The Binding of Isaac: Rebirth
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| 12. | the keeper + greed mode = AKSLJDHFLAKSJDF | 8,478 | Let's Play | The Binding of Isaac: Rebirth
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| 13. | isaac perfect accuracy challenge (this sucks) | 8,427 | Let's Play | The Binding of Isaac: Rebirth
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| 14. | MOST OP ISAAC RUN 2019 | 7,819 | Let's Play | The Binding of Isaac: Rebirth
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| 15. | I FINALLY BEAT THE STUPID MOTHER BOSS IN ISAAC | 7,717 | | The Binding of Isaac: Rebirth
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| 16. | isaac: the ultimate choke | 7,661 | Let's Play | The Binding of Isaac: Rebirth
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| 17. | TINY ISAAC VS THE LAMB | 7,251 | Let's Play | The Binding of Isaac: Rebirth
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| 18. | we did it boys (head trauma challenge) | 6,784 | Let's Play | The Binding of Isaac: Rebirth
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| 19. | THE FORGOTTEN BOSS RUSH (isaac) | 6,565 | Let's Play | The Binding of Isaac: Rebirth
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| 20. | isaac is the BOMB | 6,228 | Let's Play | The Binding of Isaac: Rebirth
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| 21. | THE BINDING OF YUB | 5,760 | Let's Play | The Binding of Isaac: Rebirth
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| 22. | bloodbag.exe | 5,725 | | The Binding of Isaac: Rebirth
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| 23. | isaac big brain challenge | 5,534 | Let's Play | The Binding of Isaac: Rebirth
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| 24. | POOP GANG | 5,419 | Let's Play | The Binding of Isaac: Rebirth
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| 25. | THE KEEPER = PURE RAGE (binding of isaac) | 5,375 | Let's Play | The Binding of Isaac: Rebirth
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| 26. | Isaac - Beating Delirium with The Lost | 5,369 | Let's Play | The Binding of Isaac: Rebirth
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| 27. | THEY ADDED GUNS TO ISAAC LMAO (g fuel mode) | 5,203 | | The Binding of Isaac: Rebirth
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| 28. | BEATING MOM'S HEART & UNLOCKING EDEN | The Binding Of Isaac Afterbirth Gameplay | 5,184 | Let's Play | The Binding of Isaac: Rebirth
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| 29. | how to get anxiety in one easy step (isaac) | 5,150 | Let's Play | The Binding of Isaac: Rebirth
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| 30. | TAINTED LOST IS IMPOSSIBLE BRO (binding of isaac) | 5,129 | | The Binding of Isaac: Rebirth
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| 31. | PEE YOURSELF CHALLENGE | The Binding Of Isaac Afterbirth Gameplay [Nintendo Switch] | 5,069 | Let's Play | The Binding of Isaac: Rebirth
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| 32. | the isaac purist challenge is not that easy | 5,044 | Let's Play | The Binding of Isaac: Rebirth
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| 33. | the CRAPPIEST challenge in binding of isaac | 4,982 | Let's Play | The Binding of Isaac: Rebirth
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| 34. | the most CURSED isaac challenge | 4,843 | Let's Play | The Binding of Isaac: Rebirth
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| 35. | the most annoying isaac challenge ever | 4,840 | Let's Play | The Binding of Isaac: Rebirth
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| 36. | isaac gets killed by poop (depressing) | 4,835 | Let's Play | The Binding of Isaac: Rebirth
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| 37. | i can't believe i just did that lol | 4,787 | Let's Play | The Binding of Isaac: Rebirth
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| 38. | FIRST TIME FIGHTING MEGA SATAN (The Binding Of Isaac) | 4,730 | Let's Play | The Binding of Isaac: Rebirth
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| 39. | binding of isaac? more like ASDHKJFAKJSDFJLASKDJF | 4,684 | | The Binding of Isaac: Rebirth
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| 40. | isaac but it's a first-person shooter game | 4,643 | Let's Play | The Binding of Isaac: Rebirth
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| 41. | my biggest isaac mistake so far... | 4,643 | Let's Play | The Binding of Isaac: Rebirth
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| 42. | isaac challenge with no tears | 4,507 | Let's Play | The Binding of Isaac: Rebirth
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| 43. | hey isaac, ya want flies with that? | 4,226 | Let's Play | The Binding of Isaac: Rebirth
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| 44. | THE ALMIGHTY CANDLE | The Binding Of Isaac Afterbirth Daily Challenge | 4,212 | Let's Play | The Binding of Isaac: Rebirth
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| 45. | isaac: the charmander challenge | 4,210 | Let's Play | The Binding of Isaac: Rebirth
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| 46. | playing as THE LOST makes me so MAD | 4,156 | Let's Play | The Binding of Isaac: Rebirth
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| 47. | SMALLEST ISAAC EVER | The Binding Of Isaac Afterbirth Gameplay [Nintendo Switch] | 4,134 | Let's Play | The Binding of Isaac: Rebirth
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| 48. | MOST STRESSFUL ISAAC RUN EVER | 4,091 | Let's Play | The Binding of Isaac: Rebirth
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| 49. | playing ISAAC REPENTANCE for an hour or so | 4,039 | | The Binding of Isaac: Rebirth
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| 50. | MOST FRANTIC ISAAC RUN EVER | 3,819 | Let's Play | The Binding of Isaac: Rebirth
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| 51. | trying terrible isaac challenges (and hating it) | 3,796 | Let's Play | The Binding of Isaac: Rebirth
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| 52. | POKEMON IN ISAAC?! | The Binding Of Isaac Afterbirth "Pokey Mans" Challenge Gameplay | 3,777 | Let's Play | The Binding of Isaac: Rebirth
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| 53. | more isaac repentance! (epic) | 3,713 | | The Binding of Isaac: Rebirth
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| 54. | NO HIT RUN - Attempt #1 (binding of isaac) | 3,665 | Let's Play | The Binding of Isaac: Rebirth
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| 55. | CLUTCH ULTRA GREED FIGHT | The Binding Of Isaac Afterbirth Gameplay [Nintendo Switch] | 3,663 | Let's Play | The Binding of Isaac: Rebirth
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| 56. | more isaac challenges that make me want to die | 3,634 | | The Binding of Isaac: Rebirth
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| 57. | ...this is why i'm dead inside lol | 3,563 | | The Binding of Isaac: Rebirth
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| 58. | AYO I UNLOCKED TAINTED FORGOTTEN HECK YA DUDE | 3,519 | | The Binding of Isaac: Rebirth
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| 59. | HUSH IS TOUGH | The Binding Of Isaac Afterbirth Gameplay [Nintendo Switch] | 3,513 | Let's Play | The Binding of Isaac: Rebirth
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| 60. | isaac - unlocking my first tainted character (hopefully) | 3,311 | | The Binding of Isaac: Rebirth
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| 61. | HURT YOURSELF CHALLENGE - isaac edition | 3,287 | | The Binding of Isaac: Rebirth
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| 62. | 99 BOMBS?! | The Binding Of Isaac Afterbirth Daily Challenge #4 | 3,167 | Let's Play | The Binding of Isaac: Rebirth
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| 63. | THE ULTIMATE ISAAC RUN | 3,146 | | The Binding of Isaac: Rebirth
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| 64. | LASER MOUTH DEMON BABY | The Binding Of Isaac Afterbirth Daily Challenge #1 | 3,042 | Let's Play | The Binding of Isaac: Rebirth
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| 65. | ISAAC IS MY FAVORITE GAME | 2,993 | | The Binding of Isaac: Rebirth
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| 66. | attempting the ultimate gamer challenge (binding of isaac) | 2,983 | Let's Play | The Binding of Isaac: Rebirth
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| 67. | YOU EAT ALL MY BEANS ISAAC?! | 2,929 | Let's Play | The Binding of Isaac: Rebirth
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| 68. | NO HIT RUN - Attempt #2 (binding of isaac) | 2,827 | Let's Play | The Binding of Isaac: Rebirth
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| 69. | I BEAT SATAN | The Binding Of Isaac Afterbirth Gameplay [Nintendo Switch] | 2,821 | Let's Play | The Binding of Isaac: Rebirth
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| 70. | ISAAC VS ISAAC?! | The Binding Of Isaac Afterbirth Gameplay | 2,740 | Let's Play | The Binding of Isaac: Rebirth
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| 71. | yub isaac repentance live stream! | 2,740 | | The Binding of Isaac: Rebirth
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| 72. | this game is impossible and i'm mad | 2,890 | | The Binding of Isaac: Rebirth
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| 73. | yub isaac livestream (gamers only) | 2,700 | Let's Play | The Binding of Isaac: Rebirth
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| 74. | worst isaac livestream on youtube | 2,577 | Let's Play | The Binding of Isaac: Rebirth
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| 75. | AZAZEL VS SATAN | The Binding Of Isaac Afterbirth Gameplay [Nintendo Switch] | 2,439 | Let's Play | The Binding of Isaac: Rebirth
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| 76. | I GOT LASERS! | The Binding Of Isaac Afterbirth "Computer Savvy" Challenge Gameplay | 2,366 | Let's Play | The Binding of Isaac: Rebirth
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| 77. | I LOVE YOU ICE CUBE BABY | 2,637 | | The Binding of Isaac: Rebirth
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| 78. | trying to make some progress in isaac repentance | 2,211 | | The Binding of Isaac: Rebirth
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| 79. | isaac - suicide king attempt #1 (livestream) | 2,145 | Let's Play | The Binding of Isaac: Rebirth
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| 80. | IT'S POOPIN TIME | 2,147 | | The Binding of Isaac: Rebirth
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| 81. | the worst character in isaac | 2,800 | | The Binding of Isaac: Rebirth
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| 82. | MOST INTENSE RUN EVER | The Binding Of Isaac Afterbirth Gameplay [Nintendo Switch] | 1,949 | Let's Play | The Binding of Isaac: Rebirth
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| 83. | failed the daily run ha ha ha ha ha ha ha | 2,239 | | The Binding of Isaac: Rebirth
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| 84. | EYE HATE THESE GUYS | The Binding Of Isaac Afterbirth Gameplay [Nintendo Switch] | 1,872 | Let's Play | The Binding of Isaac: Rebirth
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| 85. | tainted lost ONLY stream (oh no) | 1,870 | | The Binding of Isaac: Rebirth
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| 86. | I ACTUALLY WON | The Binding Of Isaac Afterbirth Daily Challenge #3 | 1,764 | Let's Play | The Binding of Isaac: Rebirth
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| 87. | STEALTH ISAAC | The Binding Of Isaac Afterbirth Gameplay | 1,659 | Let's Play | The Binding of Isaac: Rebirth
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| 88. | EXPLODING POOP | The Binding Of Isaac Afterbirth Gameplay [Nintendo Switch] | 1,414 | Let's Play | The Binding of Isaac: Rebirth
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| 89. | PEEPEE CHALLENGE COMPLETE | The Binding Of Isaac Afterbirth Gameplay [Nintendo Switch] | 1,351 | Let's Play | The Binding of Isaac: Rebirth
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| 90. | KILLED BY POOP | The Binding Of Isaac Afterbirth Daily Challenge #2 | 1,320 | Let's Play | The Binding of Isaac: Rebirth
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| 91. | HEAD TRAUMA CHALLENGE [Attempt #1] The Binding Of Isaac Afterbirth Gameplay [Nintendo Switch] | 1,285 | Let's Play | The Binding of Isaac: Rebirth
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| 92. | NO POWERUPS | The Binding Of Isaac Afterbirth Gameplay | 1,054 | Let's Play | The Binding of Isaac: Rebirth
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| 93. | isaac REPENTANCE is too HARD (emotional) | 0 | | The Binding of Isaac: Rebirth
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| 94. | isaac - trying AGAIN to beat mother (i suck) | 0 | | The Binding of Isaac: Rebirth
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| 95. | isaac repentance is finally on switch! | 0 | | The Binding of Isaac: Rebirth
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| 96. | isaac but with more farting | 2,309 | | The Binding of Isaac: Rebirth
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| 97. | I LOVE THIS ITEM SO MUCH | 2,481 | | The Binding of Isaac: Rebirth
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