| 401. | Proof That A New Savefile Gives You Better Runs: | Isaac Deathless Savefile | 10 | | The Binding of Isaac: Rebirth
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| 402. | This Is By Far The STRONGEST Item I've Ever Seen. | The Binding Of Isaac Repentance | 25 | | The Binding of Isaac: Rebirth
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| 403. | This NEW Knife Item Makes You INVINCIBLE? | The Binding Of Isaac Repentance | 19 | | The Binding of Isaac: Rebirth
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| 404. | The History Of Isaac Youtubers Explained | 181 | | The Binding of Isaac: Rebirth
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| 405. | What 4000h Taught Me In The Binding Of Isaac Repentance: | 67 | | The Binding of Isaac: Rebirth
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| 406. | Forcing A 5 Year Old Angel To Fight For A Profit | Isaac Repentance No Death | 17 | | The Binding of Isaac: Rebirth
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| 407. | COOP Isaac With Custom Builds! Ft. @KayhosYT | 35 | | The Binding of Isaac: Rebirth
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| 408. | How I COMPLETELY Broke Isaac In ONE FLOOR. | 64 | | The Binding of Isaac: Rebirth
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| 409. | This Is The BEST SYNERGY You'll Ever See. | 43 | | The Binding of Isaac: Rebirth
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| 410. | Playable Dogma Is The Most FRUSTRATING Character Ever. | 73 | | The Binding of Isaac: Rebirth
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| 411. | I Tried Isaac's Most BROKEN Challenge! | 43 | | The Binding of Isaac: Rebirth
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| 412. | How I Broke Isaac With This NEW Character's Dice: | 94 | | The Binding of Isaac: Rebirth
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| 413. | The Most RIGGED Isaac Item Of ALL TIME! | 97 | | The Binding of Isaac: Rebirth
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| 414. | I Challenged The SMARTEST Isaactuber To Beat UltraHard. | Ft. @lazymattman | 596 | | The Binding of Isaac: Rebirth
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| 415. | .. ... --. --- -. . | 28 | | The Binding of Isaac: Rebirth
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| 416. | THEY ALREADY ADDED NEW ACHIEVEMENTS FOR ISAAC ONLINE! | 82 | | The Binding of Isaac: Rebirth
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| 417. | Is Azazel ACTUALLY The Strongest Character? | 70 | | The Binding of Isaac: Rebirth
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| 418. | Least Rigged YouTuber Run: | 39 | | The Binding of Isaac: Rebirth
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| 419. | The ULTIMATE Run Before Isaac Online Drops. | 31 | | The Binding of Isaac: Rebirth
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| 420. | How I Got The Twisted Pair World Record: | 32 | | The Binding of Isaac: Rebirth
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| 421. | How To Play Isaac CO-OP Online! | 50 | | The Binding of Isaac: Rebirth
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| 422. | Proof That Tainted Lost Is EASY. | 10 | | The Binding of Isaac: Rebirth
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| 423. | Trying YOUR Strongest Synergies In Isaac #shorts #gaming #isaac #tboi #achievement | 32 | | The Binding of Isaac: Rebirth
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| 424. | They Added NEW Dragon Bosses, They're AWESOME | The Binding Of Isaac Repentance+ | 32 | | The Binding of Isaac: Rebirth
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| 425. | This Is The LUCKIEST Run You'll Ever See. | 22 | | The Binding of Isaac: Rebirth
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| 426. | This NEW Character Has INFINITE Potential | The Binding Of Isaac Repentance | 25 | | The Binding of Isaac: Rebirth
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| 427. | This NEW Floor Is Absolutely BROKEN. | 21 | | The Binding of Isaac: Rebirth
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| 428. | Can You Beat Isaac With The WORST Item In The Game? (Repentance+) | 41 | | The Binding of Isaac: Rebirth
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| 429. | These NEW Planetarium Items Are MASSIVELY Broken. | 78 | | The Binding of Isaac: Rebirth
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| 430. | How One Single Item Can Completely Break Your Game: | The Binding Of Isaac Repentance | 12 | | The Binding of Isaac: Rebirth
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| 431. | I Made Isaac The STRONGEST 5yo EVER | #tboi #repentance #thebindingofisaac #isaac #gaming | 48 | | The Binding of Isaac: Rebirth
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| 432. | Why T. Keeper Is The EASIEST Character Ever. | 72 | | The Binding of Isaac: Rebirth
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| 433. | Playing GREEDIEST Character In Isaac | 30 | | The Binding of Isaac: Rebirth
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| 434. | This NEW Character Has The MOST BROKEN Dice Of All Time. | 63 | | The Binding of Isaac: Rebirth
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| 435. | How To INSTANTLY Break Any Isaac Run: | 75 | | The Binding of Isaac: Rebirth
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| 436. | The NEW Hardest Challenge In Isaac! | 54 | | The Binding of Isaac: Rebirth
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| 437. | The BIGGEST Isaac Update Is REAL! | 227 | | The Binding of Isaac: Rebirth
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| 438. | These Mods Shouldn't Be Allowed. | The Binding Of Isaac Repentance | 33 | | The Binding of Isaac: Rebirth
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| 439. | 10 Mods Isaac Players Need To Use NOW! | The Binding Of Isaac Repentance | 59 | | The Binding of Isaac: Rebirth
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| 440. | This NEW MECHANIC Changes EVERYTHING! | 25 | | The Binding of Isaac: Rebirth
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| 441. | They Gave Isaac A NEW Dance, It's Peak. | The Binding Of Isaac Repentance | 23 | | The Binding of Isaac: Rebirth
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| 442. | The Journey To Unlock The Lost Begins | RTDG | 26 | | The Binding of Isaac: Rebirth
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| 443. | ACTUALLY Rigged Youtuber Run: | 51 | | The Binding of Isaac: Rebirth
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| 444. | The Series Is Back, Now It Gets Hard. | 10 | | The Binding of Isaac: Rebirth
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