| 301. | Least RIGGED Youtuber Run | 1,142 | | The Binding of Isaac: Rebirth
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| 302. | This Is The BEST SYNERGY You'll Ever See. | 1,135 | | The Binding of Isaac: Rebirth
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| 303. | How I Got ALL The QUALITY4 Items In The Game | 1,132 | | The Binding of Isaac: Rebirth
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| 304. | This Is What Peak Isaac Modding Looks Like: | 1,124 | | The Binding of Isaac: Rebirth
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| 305. | STRONGEST Transformation In Isaac | 1,116 | | The Binding of Isaac: Rebirth
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| 306. | Why You Should Delete Your Dead God. | The Binding Of Isaac Repentance | 1,110 | | The Binding of Isaac: Rebirth
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| 307. | Breaking Isaac With The WORST Items | 1,087 | | The Binding of Isaac: Rebirth
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| 308. | The MOST EXPLOSIVE Synergy In The Game | 1,080 | | The Binding of Isaac: Rebirth
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| 309. | Isaac's Most Broken Item, But I'm ALWAYS Blind! | 1,079 | | The Binding of Isaac: Rebirth
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| 310. | Something's wrong with Isaac. | 1,072 | | The Binding of Isaac: Rebirth
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| 311. | How I Got The EASIEST Run Ever | 1,072 | | The Binding of Isaac: Rebirth
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| 312. | Making Greed Mode Peak Fun: | 1,071 | |
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| 313. | The Most RIGGED Secret Room Run | 1,060 | | The Binding of Isaac: Rebirth
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| 314. | How I Got EVERY Item In The Game! | 1,059 | | The Binding of Isaac: Rebirth
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| 315. | Unlocking Forgotten, But If I Die I DELETE My Savefile: (Repentance+) | 1,050 | | The Binding of Isaac: Rebirth
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| 316. | They Put FNAF PURPLE GUY In Isaac?! | 1,033 | | The Binding of Isaac: Rebirth
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| 317. | The CRAZIES rerolls EVER! | 1,029 | | The Binding of Isaac: Rebirth
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| 318. | How We Took T. Lost Damocles To ANOTHER LEVEL. | 1,027 | | The Binding of Isaac: Rebirth
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| 319. | I Tried Tarnished Isaac. It was Insane. | 1,025 | | The Binding of Isaac: Rebirth
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| 320. | How I BROKE Isaac With Infinite Basements! | 1,020 | | The Binding of Isaac: Rebirth
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| 321. | This NEW R-Key Is Insanely Broken! | 1,019 | | The Binding of Isaac: Rebirth
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| 322. | The LUCKIEST Reroll In The Game | 1,014 | | The Binding of Isaac: Rebirth
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| 323. | Goodbye, Devil Deals. | 1,006 | | The Binding of Isaac: Rebirth
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| 324. | How I Make Jacob & Esau Look EASY:(Repentance+) | 1,005 | | The Binding of Isaac: Rebirth
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| 325. | The MOST UNDERRATED Item In The Game!? | 1,004 | | The Binding of Isaac: Rebirth
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| 326. | This Synergy INSTANTLY Killed Mother | 998 | | The Binding of Isaac: Rebirth
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| 327. | What 4000h Taught Me In The Binding Of Isaac Repentance: | 998 | | The Binding of Isaac: Rebirth
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| 328. | COOP Isaac With Custom Builds! Ft. @KayhosYT | 997 | | The Binding of Isaac: Rebirth
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| 329. | How I Officially BROKE Isaac #gaming #isaac #shorts #mods #repentance #rigged | 973 | | The Binding of Isaac: Rebirth
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| 330. | Isaac, But EVERY Item Is GLITCHED! | 971 | | The Binding of Isaac: Rebirth
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| 331. | They FINALLY Released Mattman's Secret Mods! | The Binding Of Isaac Repentance | 964 | | The Binding of Isaac: Rebirth
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| 332. | These NEW SYNERGIES are AMAZING | 958 | | The Binding of Isaac: Rebirth
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| 333. | This Is The BEST Synergy EVER. | Streaking | 951 | | The Binding of Isaac: Rebirth
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| 334. | They Added NEW Curses To Isaac. It's Crazy. | 942 | | The Binding of Isaac: Rebirth
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| 335. | Levelling Up Blue Baby In Isaac's NEW UPDATE! | 935 | | The Binding of Isaac: Rebirth
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| 336. | Playable Goathead Is ABSOLUTELY Insane | 931 | | The Binding of Isaac: Rebirth
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| 337. | The CRAZIEST Damocles Start You'll Ever See | 920 | | The Binding of Isaac: Rebirth
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| 338. | The ULTIMATE Enemy Destroyer Synergy | The Binding Of Isaac Repentance EP. #5 | 920 | | The Binding of Isaac: Rebirth
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| 339. | 2h 20 Of Me Suffering With You Until The Ultrakill 8-1 Release | 903 | |
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| 340. | Blind Items Are INSANE | 900 | | The Binding of Isaac: Rebirth
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| 341. | This Item Can RIG Every Run! | 899 | | The Binding of Isaac: Rebirth
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| 342. | How I Got The STRONGEST Isaac Run EVER | 892 | | The Binding of Isaac: Rebirth
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| 343. | The Run That BROKE Our Game | 888 | | The Binding of Isaac: Rebirth
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| 344. | I Tried Isaac's Most BROKEN Challenge! | 885 | | The Binding of Isaac: Rebirth
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| 345. | The FASTEST R Key Find You'll Ever See. | The Binding Of Isaac Repentance | 884 | | The Binding of Isaac: Rebirth
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| 346. | How I Got The Death Certificate SPEEDRUN World Record | 878 | | The Binding of Isaac: Rebirth
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| 347. | How We DESTROYED Delirium | 876 | | The Binding of Isaac: Rebirth
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| 348. | Santa is Isaac's Most Broken Modded Character? | 872 | | The Binding of Isaac: Rebirth
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| 349. | They Made This Character TOO LUCKY | 871 | | The Binding of Isaac: Rebirth
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| 350. | CRAZIEST R-Key Run | 850 | | The Binding of Isaac
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| 351. | This NEW Dice Turns ALL Items Into Quality4! | The Binding Of Isaac Repentance | 847 | | The Binding of Isaac: Rebirth
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| 352. | 10 Minutes Of Isaac Breaking It Down | 838 | | The Binding of Isaac: Rebirth
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| 353. | Tarnished Lost Is Simply BROKEN | 836 | | The Binding of Isaac: Rebirth
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| 354. | This NEW Character Is Completely RIGGED | 834 | | The Binding of Isaac: Rebirth
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| 355. | They Gave Magic Skin A MASSIVE Upgrade, It's Broken. | 833 | | The Binding of Isaac: Rebirth
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| 356. | Almond Milk CARRIED Our Run | 830 | | The Binding of Isaac: Rebirth
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| 357. | Least Rigged YouTuber Run: | 827 | | The Binding of Isaac: Rebirth
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| 358. | Making The HARDEST Character Look EASY | 823 | | The Binding of Isaac: Rebirth
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| 359. | The ULTIMATE Run Before Isaac Online Drops. | 808 | | The Binding of Isaac: Rebirth
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| 360. | POV: You Use 100% Of Your Luck | 806 | | The Binding of Isaac: Rebirth
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| 361. | Taking Damage = Become Unstoppable | 803 | | The Binding of Isaac: Rebirth
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| 362. | The PROOF That I Can Rig ANY Run: | Streaking | 784 | | The Binding of Isaac: Rebirth
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| 363. | Making A Rig Look EASY: | 778 | | The Binding of Isaac: Rebirth
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| 364. | ACTUALLY Rigged Youtuber Run: | 775 | | The Binding of Isaac: Rebirth
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| 365. | These NEW Items Are Actually AMAZING | 771 | | The Binding of Isaac: Rebirth
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| 366. | They Added SPLATOON To Isaac!! | 768 | | The Binding of Isaac: Rebirth
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| 367. | This NEW Glitch Makes This Item INSANELY Broken. | 760 | | The Binding of Isaac: Rebirth
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| 368. | I Made Damoclese Stackable, It Was A Mistake... | The Binding Of Isaac Repentance | 760 | | The Binding of Isaac: Rebirth
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| 369. | The Start That DESTROYED Delirium | 751 | | The Binding of Isaac: Rebirth
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| 370. | These Items Made Us UNSTOPPABLE | 745 | | The Binding of Isaac: Rebirth
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| 371. | These Isaac Mods Need To STOP! (Repentance+) | 742 | | The Binding of Isaac: Rebirth
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| 372. | Is This The MOST OVERRATED Quality4 Item? | 738 | | The Binding of Isaac: Rebirth
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| 373. | This Is How I Got EVERY Item In Isaac: | 737 | | The Binding of Isaac: Rebirth
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| 374. | Playing GREEDIEST Character In Isaac | 737 | | The Binding of Isaac: Rebirth
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| 375. | This NEW Character Is SO SCARY | 732 | | The Binding of Isaac: Rebirth
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| 376. | Can You Beat Isaac With The WORST Item In The Game? (Repentance+) | 731 | | The Binding of Isaac: Rebirth
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| 377. | This NEW Floor Is Absolutely BROKEN. | 724 | | The Binding of Isaac: Rebirth
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| 378. | These Random Items Are RIGGED | 724 | | The Binding of Isaac: Rebirth
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| 379. | Isaac But Every 10s ALL Items Get Rerolled | 722 | | The Binding of Isaac: Rebirth
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| 380. | Playing The Hardest Character In The Game Was A Mistake | 720 | | The Binding of Isaac: Rebirth
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| 381. | This NEW Character Gives INFINITE Stats! | 715 | | The Binding of Isaac: Rebirth
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| 382. | Rigging With The WORST Character EVER! | 705 | | The Binding of Isaac: Rebirth
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| 383. | My Fans Synergies are BROKEN! | EP. #1 | 704 | | The Binding of Isaac: Rebirth
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| 384. | This Is The HIGHEST Damage You'll Ever See. (Repentance+) | 701 | | The Binding of Isaac: Rebirth
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| 385. | Super Mario and Luigi, But It's Isaac! | 700 | | The Binding of Isaac: Rebirth
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| 386. | The LUCKIEST Reroll In The Game | 700 | | The Binding of Isaac: Rebirth
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| 387. | This Item Gives You INFINITE Split Tears. | 684 | | The Binding of Isaac: Rebirth
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| 388. | Thomas Shelby's Grief | Peaky Blinders #peakyblinders #peakyblindersedit #thomasshelby #sigmarule | 675 | |
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| 389. | -- .- --. --. -.-- | 672 | | The Binding of Isaac: Rebirth
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| 390. | They Added The Devil Deal Dice, It's BROKEN! | The Binding Of Isaac Repentance | 669 | | The Binding of Isaac: Rebirth
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| 391. | They Added DRIP To Isaac And It's WILD | 661 | | The Binding of Isaac: Rebirth
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| 392. | How I COMPLETELY Broke The HARDEST challenge In Isaac. | 661 | | The Binding of Isaac: Rebirth
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| 393. | This NEW Tech Item Completely Broke My Game. (Repentance+) | 659 | | The Binding of Isaac: Rebirth
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| 394. | Is This The WEIRDEST Synergy Ever? | Ep. #3 | 659 | | The Binding of Isaac: Rebirth
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| 395. | Proving Why THIS is Isaac's Worst Game Mode: (Repentance+ Road To Dead God) | 644 | | The Binding of Isaac: Rebirth
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| 396. | They Buffed Damocles, It's Insane. | The Binding Of Isaac Repentance | 628 | | The Binding of Isaac: Rebirth
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| 397. | T. Jacob Is The Easiest Character, Here's Proof | The Binding Of Isaac Repentance | 627 | | The Binding of Isaac: Rebirth
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| 398. | Can You Beat Isaac Without Damage Up Items? (Repentance+) | 625 | | The Binding of Isaac: Rebirth
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| 399. | This NEW CHARACTER Is Absolutely HILARIOUS, You'll Love him! | 624 | | The Binding of Isaac: Rebirth
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| 400. | The Cutest Isaac Character Ever | 622 | | The Binding of Isaac: Rebirth
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