| 1. | The entire Isaac Squad dances for good Items. | 40,239 | | The Binding of Isaac: Rebirth
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| 2. | The CREEPIEST Isaac Boss EVER! Cacophobia (Fiend Folio) | 34,142 | | The Binding of Isaac: Rebirth
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| 3. | Brimstone Sound Comparison! | 30,455 | | Brimstone
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| 4. | 5 Boss Secrets That ALL Players Need To Know! (Repentance) | 29,130 | | The Binding of Isaac: Rebirth
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| 5. | Rock Bottom + Ipecac is absolutely insane. | 25,284 | | The Binding of Isaac: Rebirth
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| 6. | The Most SATISFYING Dark Arts Use! (Isaac Repentance) #shorts | 24,688 | | The Binding of Isaac: Rebirth
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| 7. | All Horse Pills/Giant Pills (With Sound) - The Binding of Isaac: Repentance | 18,628 | | The Binding of Isaac: Rebirth
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| 8. | Rock Bottom + Soy Milk + Kidney Stone = 90 Tear Rate (totally balanced) | 18,620 | | The Binding of Isaac: Rebirth
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| 9. | NEW Soul Stone Consumables! - The Binding of Isaac: Repentance | 18,215 | | The Binding of Isaac: Rebirth
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| 10. | Use This Trick To Get More Items! - The Bomb Cancel | 16,898 | | The Binding of Isaac: Rebirth
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| 11. | You can actually break the Dummy in Repentance! | 16,269 | | The Binding of Isaac: Rebirth
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| 12. | Top 10 NEW Items in The Binding of Isaac: Repentance! | 16,089 | | The Binding of Isaac: Rebirth
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| 13. | All GIGA BOMB Synergies! - The Binding of Isaac Repentance | 15,970 | | The Binding of Isaac: Rebirth
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| 14. | 5 easy/fun Ways to kill The Beast! The Binding of Isaac Repentance | 15,862 | | The Binding of Isaac: Rebirth
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| 15. | Azazel's Default Mega Blast! - Viewer Synergies #1 (SlayXc2) | 15,137 | Show | The Binding of Isaac: Rebirth
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| 16. | 22 NEW Reverse Tarot Cards! - The Binding of Isaac: Repentance | 14,328 | | The Binding of Isaac: Rebirth
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| 17. | The Secret of "34" - How to unlock Tainted Characters in Repentance! | 14,210 | Guide | The Binding of Isaac: Rebirth
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| 18. | The REAL Slim Shady! | 14,059 | | The Binding of Isaac: Rebirth
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| 19. | NEW Brimstone Synergies in Repentance! | 14,042 | | Brimstone
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| 20. | The One Punch Man Item Build! - The Binding of Isaac: Repentance | 13,323 | | The Binding of Isaac: Rebirth
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| 21. | Athame Satisfactory!😵 | 13,137 | | The Binding of Isaac: Rebirth
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| 22. | NEW Soy Milk Synergies in Repentance! | 13,037 | | The Binding of Isaac: Rebirth
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| 23. | Top 10 most NERFED Items in The Binding of Isaac: Repentance! | 13,001 | | The Binding of Isaac: Rebirth
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| 24. | All NEW Pickups in Repentance! - The Binding of Isaac: Repentance | 12,991 | | The Binding of Isaac: Rebirth
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| 25. | Big Horn Dislikes Smoke! (Isaac Tips n' Trivia) | 14,020 | | The Binding of Isaac: Rebirth
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| 26. | What happens if you have ALL ITEMS in Repentance? (For Science!) | 12,408 | | The Binding of Isaac: Rebirth
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| 27. | The Sleeper's Scary Domain! Fiend Folio: The Depths | 12,255 | | The Binding of Isaac: Rebirth
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| 28. | Rare Giant Obstacles With Crazy Loot! | 12,087 | | The Binding of Isaac: Rebirth
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| 29. | Use these 2 Mods if you are angry at Edmund McMillen. | 11,945 | | The Binding of Isaac: Rebirth
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| 30. | The History of Brimstone! 2011-2022 (The Binding of Isaac) | 11,942 | | The Binding of Isaac
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| 31. | Rock Bottom + Succubus = Insane Damage Stacking | 11,859 | | The Binding of Isaac: Rebirth
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| 32. | Andromeda - Planetariums in every Run! (Mod Showcase) | 11,744 | Show | The Binding of Isaac: Rebirth
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| 33. | Poop Satisfactory!!!💩💩💩 | 13,726 | | The Binding of Isaac: Rebirth
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| 34. | ALL Changes to Transformations in Repentance! | 11,492 | | The Binding of Isaac: Rebirth
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| 35. | 5 easy/fun Ways to kill Delirium! The Binding of Isaac Repentance | 11,477 | | The Binding of Isaac: Rebirth
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| 36. | Mega Mush Blast! - The Best Combo in Repentance? | 11,326 | | The Binding of Isaac: Rebirth
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| 37. | You can Break Forgotten with ONE Item! (Death Certificate + Forgotten) | 11,198 | | The Binding of Isaac: Rebirth
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| 38. | Only pick 2 of them, NEVER all 3! (Isaac Repentance) | 10,962 | | The Binding of Isaac: Rebirth
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| 39. | Breaking the Best Item in Repentance - Thanks for 10.000 Subscribers! | 10,863 | | The Binding of Isaac: Rebirth
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| 40. | NEW Mom's Knife Synergies in Repentance! | 10,390 | | The Binding of Isaac: Rebirth
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| 41. | NEW Planetarium Room Explained - The Binding of Isaac: Repentance | 10,386 | | The Binding of Isaac: Rebirth
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| 42. | Top 10 most BUFFED Items in The Binding of Isaac: Repentance! | 10,216 | | The Binding of Isaac: Rebirth
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| 43. | Car - The Automobile | Character Showcase! (Repentance Mod) | 10,118 | Show | The Binding of Isaac: Rebirth
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| 44. | Is this the last Secret of Repentance? Or just a Bug? | 9,897 | | The Binding of Isaac: Rebirth
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| 45. | 5 easy/fun Ways to kill HUSH! The Binding of Isaac Repentance | 9,831 | | The Binding of Isaac: Rebirth
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| 46. | What are the MAX possible stats in Isaac? (Repentance) | 9,770 | | The Binding of Isaac: Rebirth
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| 47. | All NEW Beggars In Fiend Folio Explained! | 9,555 | | The Binding of Isaac: Rebirth
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| 48. | The Thinnest Brimstone Beam Possible! | 9,482 | | Brimstone
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| 49. | 500 People tried to crash my Game... | 9,393 | | The Binding of Isaac: Rebirth
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| 50. | Ultimate Zap Build! - Viewer Synergies #2 (SlayXc2) | 9,371 | Show | The Binding of Isaac: Rebirth
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| 51. | Baby Plum Gets What She Deserves! | 9,195 | | The Binding of Isaac: Rebirth
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| 52. | The Sith Lord Item Build! - The Binding of Isaac: Repentance | 9,099 | | The Binding of Isaac: Rebirth
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| 53. | New Beggars and Machines! - The Binding of Isaac: Repentance | 9,092 | | The Binding of Isaac: Rebirth
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| 54. | Death Certificate - Item Guide - The Binding of Isaac: Repentance | 9,028 | Guide | The Binding of Isaac: Rebirth
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| 55. | The Hollow - New Fly based Character! (Mod Showcase) | 8,970 | Show | The Binding of Isaac: Rebirth
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| 56. | Isaac can literally turn into a Beyblade in Repentance xD | 8,954 | | The Binding of Isaac: Rebirth
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| 57. | 420 - Secret Easter Egg Animation! (Fiend Folio) | 8,725 | | The Binding of Isaac: Rebirth
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| 58. | All New GOLDEN TRINKET Effects!!! (Repentance Patch 1.7.9) | 8,642 | | The Binding of Isaac: Rebirth
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| 59. | You can play PvP in Isaac! - Repentance Possessor Mode | 8,563 | | The Binding of Isaac: Rebirth
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| 60. | This Item Starts A Shady Side-Quest!!! (Fiend Folio) | 8,474 | | The Binding of Isaac: Rebirth
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| 61. | Tarnished Eden Explained - Debug Your Destiny! | 8,471 | | The Binding of Isaac: Rebirth
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| 62. | What happens if you void ALL active items? (Repentance) | 8,335 | | The Binding of Isaac: Rebirth
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| 63. | How to become 100% Bullet-Proof in Isaac. | 8,291 | Guide | The Binding of Isaac: Rebirth
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| 64. | INSANE New Character! Lairub | 莱鲁布 (Mod Showcase) | 8,170 | Show | The Binding of Isaac: Rebirth
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| 65. | The History of Mom's Knife! 2011-2022 (The Binding of Isaac) | 8,163 | | The Binding of Isaac
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| 66. | The Secret Boss Badges In Fiend Folio Explained! | 8,113 | | The Binding of Isaac: Rebirth
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| 67. | Tarnished Keeper Explained! - Scale Your Business! | 8,085 | | The Binding of Isaac: Rebirth
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| 68. | How to get 2 choice items at once in Isaac Repentance! | 12,866 | | The Binding of Isaac: Rebirth
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| 69. | NEW Tech X Synergies in Repentance! | 7,905 | | The Binding of Isaac: Rebirth
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| 70. | 300 People tried to crash my Game...again! | 7,865 | | The Binding of Isaac: Rebirth
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| 71. | You can Break Tainted Bethany with ONE Item! (Converter + Tainted Bethany) | 7,861 | | The Binding of Isaac: Rebirth
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| 72. | Tarnished Judas Explained - Embrace Your Sins! | 7,750 | | The Binding of Isaac: Rebirth
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| 73. | Top 5 Ways to get rid of Dark Esau! (How to cheese Tainted Jacob) | 7,746 | Guide | The Binding of Isaac: Rebirth
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| 74. | Isaac Takes A Deadly Dose... All NEW Pills In Fiend Folio! | 7,596 | | The Binding of Isaac: Rebirth
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| 75. | Sausage - The only TRUE All Stats Up - The Binding of Isaac Repentance | 7,523 | | The Binding of Isaac: Rebirth
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| 76. | New "Tainted" Enemies in Repentance! (Home/Ascent Path) | 7,484 | | The Binding of Isaac: Rebirth
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| 77. | Fiend Folio is kinda SUS... | 7,430 | | The Binding of Isaac: Rebirth
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| 78. | You NEED to understand Rock Bottom!!! (Rock Bottom Item Guide) | 7,350 | Guide | The Binding of Isaac: Rebirth
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| 79. | Top 10 NEW Trinkets in The Binding of Isaac: Repentance! | 7,294 | | The Binding of Isaac: Rebirth
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| 80. | Did you know this Item can KILL BOSSES ??? (Vade Retro Guide) | 7,288 | Guide | The Binding of Isaac: Rebirth
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| 81. | 6 Playable Horseman Characters! - Mod Showcase (Repentance) | 7,271 | Show | The Binding of Isaac: Rebirth
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| 82. | NEW Trisagion Synergies in Repentance! | 7,264 | | The Binding of Isaac: Rebirth
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| 83. | Tainted Judas is our Savior! | 7,210 | | The Binding of Isaac: Rebirth
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| 84. | The Most DISGUSTING Floor?! 😨 Fiend Folio: The Corpse | 7,156 | | The Binding of Isaac: Rebirth
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| 85. | You NEED to know this Trick for Jacob & Esau! (Part 1) | 7,146 | | The Binding of Isaac: Rebirth
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| 86. | What happens if you have ALL ITEMS in Isaac? (2022) | 7,057 | | The Binding of Isaac: Rebirth
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| 87. | The Taunting Of Isaac! (Pizza Tower) | 8,124 | | The Binding of Isaac: Rebirth
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| 88. | The Binding of Isaac meets Plants VS Zombies! First Look at "I.RULE" | 6,964 | First Impressions | Plants vs. Zombies
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| 89. | Holy Crap! All NEW Poops In Fiend Folio! | 6,919 | | The Binding of Isaac: Rebirth
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| 90. | How to find the ULTRA SECRET Room? (Red Key Guide) | 6,875 | Guide | The Binding of Isaac: Rebirth
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| 91. | TAINTED Andromeda - The Black Hole! (Mod Showcase) | 6,769 | Show | The Binding of Isaac: Rebirth
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| 92. | My Shadow Is INSANE Now!!! (Repentance Patch 1.7.9) | 6,760 | | The Binding of Isaac: Rebirth
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| 93. | Breath of Life got a HUGE BUFF! (Repentance Patch 1.7.9) | 6,490 | | The Binding of Isaac: Rebirth
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| 94. | You can Break Tainted Maggy with ONE Item! (Sharp Plug + Tainted Maggy) | 6,389 | | The Binding of Isaac: Rebirth
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| 95. | What if we BUFF them instead? (Psy Fly and Echo Chamber) | 6,353 | | The Binding of Isaac: Rebirth
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| 96. | The Infinite Ascent Loop! (New Game Break) | 6,348 | | The Binding of Isaac: Rebirth
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| 97. | This Suplex glitch can ONE-SHOT every boss! (Tainted Samson + Suplex!) | 6,337 | | The Binding of Isaac: Rebirth
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| 98. | More "Tainted" Enemies!!! Fiend Folio: The Ascent | 6,284 | | The Binding of Isaac: Rebirth
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| 99. | Sodom and Gomorrah - Character Showcase (Mod) - Isaac Repentance | 6,209 | | The Binding of Isaac: Rebirth
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| 100. | This Mod BUFFS All Bad Transformations!!! | 6,206 | | The Binding of Isaac: Rebirth
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