| 1. | Exploiting Isaac's HIDDEN Mechanic! #shorts | 17,936 | | The Binding of Isaac: Rebirth
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| 2. | Worlds FASTEST Isaac Repentance Run [WR] [Random Seed] | 13,090 | | The Binding of Isaac: Rebirth
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| 3. | The Binding of Isaac Iceberg Explained | 9,879 | | The Binding of Isaac: Rebirth
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| 4. | That's... That's not good... | 8,762 | | The Binding of Isaac: Rebirth
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| 5. | How many characters can you unlock in your very first repentance run? | 8,201 | | The Binding of Isaac: Rebirth
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| 6. | How YOU can unlock 30 characters in your VERY FIRST Repentance run: I was wrong!! | 8,105 | | The Binding of Isaac: Rebirth
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| 7. | Isaac's most Difficult Challenge has been beaten - The 30 Character Run | 7,517 | | The Binding of Isaac: Rebirth
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| 8. | How Repentance CHANGED The Meta - Pro Player's Analysis + Which is Better? | 7,034 | | The Binding of Isaac: Rebirth
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| 9. | The Isaac Community's Hidden Groomer | 6,600 | | The Binding of Isaac: Rebirth
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| 10. | How to piss off any Isaac fan in less than 30 seconds | 6,041 | | The Binding of Isaac: Rebirth
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| 11. | Choose your Own Adventure #shorts | 5,300 | | The Binding of Isaac: Rebirth
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| 12. | TWO Planetarium Items on FLOOR ONE #shorts | 4,351 | | The Binding of Isaac: Rebirth
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| 13. | The Void Floor: What Went Wrong? | 4,254 | | The Binding of Isaac: Rebirth
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| 14. | This New Boss Does Not Give Up | 3,896 | | The Binding of Isaac: Rebirth
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| 15. | A Critical Analysis of the Alt Floors: Do They Belong In Isaac? (Part 1/2) | 3,830 | | The Binding of Isaac: Rebirth
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| 16. | Greed Mode: What Went Wrong? | 3,378 | | The Binding of Isaac: Rebirth
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| 17. | WE GOT THE GOLDEN HORSE PILL (And It Gave us Rock Bottom) #shorts | 3,271 | | The Binding of Isaac: Rebirth
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| 18. | Don't Shoot and You Win. | 3,266 | | The Binding of Isaac: Rebirth
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| 19. | Everything You Need to Know about Repentance v1.7.5 In 10 Minutes | 3,248 | | The Binding of Isaac: Rebirth
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| 20. | Who Has The Best Birthright in Repentance? (1.7.5) | 2,907 | | The Binding of Isaac: Rebirth
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| 21. | Why I love Modded Isaac #shorts | 2,900 | | The Binding of Isaac
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| 22. | Someone Remade The Binding of Isaac in First Person... [Cry Baby] | 2,819 | | The Binding of Isaac: Rebirth
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| 23. | This Dice Room Breaks EVERY SINGLE RULE #shorts | 2,805 | | The Binding of Isaac: Rebirth
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| 24. | How to lose a world record pace Isaac run | 2,743 | |
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| 25. | TBOI: Nuzlocke Trailer | 2,599 | | The Binding of Isaac: Rebirth
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| 26. | J A I L | 2,573 | | The Binding of Isaac: Rebirth
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| 27. | What Happens if you use R KEY on the BASE MENT seed? | 2,512 | | The Binding of Isaac: Rebirth
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| 28. | i've NEVER seen THIS on floor one #shorts | 2,466 | | The Binding of Isaac: Rebirth
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| 29. | Can Twitch Chat Beat The Binding of Isaac? | 2,298 | | The Binding of Isaac: Rebirth
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| 30. | TBOI Death% Speedrun [FORMER] World Record [00:01.11] | 2,193 | | The Binding of Isaac: Rebirth
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| 31. | How many runs does it take to unlock EVERYTHING in Repentance? (Part 1) | 2,151 | | The Binding of Isaac: Rebirth
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| 32. | What its like grinding for WORLD RECORD | 2,151 | | The Binding of Isaac: Rebirth
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| 33. | HUGE New Repentance Mod: The Binding of Isaac: Epiphany (Characters, Items, Unlocks, and more!) | 2,139 | | The Binding of Isaac: Rebirth
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| 34. | How to Break Tainted Keeper with One Item | 2,094 | Guide | The Binding of Isaac: Rebirth
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| 35. | Binding of Isaac Youtuber Tier List | 2,094 | | The Binding of Isaac: Rebirth
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| 36. | Why Does This Character Exist | 1,845 | | The Binding of Isaac: Rebirth
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| 37. | SECRET BINDING OF ISAAC REPENTANCE MODE: YOU CAN CONTROL BOSSES?! (Possessor Mode) | 1,746 | | The Binding of Isaac: Rebirth
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| 38. | Can You Beat Isaac with the MAXIMUM Number of Easter Egg Seeds? | 1,709 | | The Binding of Isaac: Rebirth
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| 39. | Gaining 400 Damage from ONE FLOOR #shorts | 1,708 | | The Binding of Isaac: Rebirth
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| 40. | TBOI: Repentance Greed mode in 9:44.49 [WR] | 1,686 | | The Binding of Isaac: Rebirth
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| 41. | The Biggest Problem With This Community. | 1,671 | Review | The Binding of Isaac: Rebirth
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| 42. | How many MORE characters can you unlock in your very first repentance run? (Part Two) | 1,621 | | The Binding of Isaac: Rebirth
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| 43. | Is This The Greatest Re-Roll Of All Time? #shorts | 1,609 | | The Binding of Isaac: Rebirth
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| 44. | So, Sinvicta TRIED To respond to me... (Sin's now deleted response + rampant lies) | 1,593 | | The Binding of Isaac: Rebirth
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| 45. | NEVER Skip Cursed Rooms!!! #shorts | 1,588 | | The Binding of Isaac: Rebirth
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| 46. | How To Delete The Un-Killable | 1,582 | | The Binding of Isaac: Rebirth
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| 47. | Ranking EVERY SINGLE BOSS In Repentance | 1,577 | | The Binding of Isaac: Rebirth
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| 48. | Why you should NEVER ignore Sac Rooms... | 1,573 | | The Binding of Isaac: Rebirth
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| 49. | The Most BROKEN Genesis yet... | 1,566 | | The Binding of Isaac: Rebirth
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| 50. | Delirium is a Skill Based Boss | 1,521 | | The Binding of Isaac: Rebirth
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| 51. | I Found The WORST Binding of Isaac Knock-off... | 1,474 | | The Binding of Isaac: Rebirth
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| 52. | Addressing The "Allegations". | 1,447 | | The Binding of Isaac: Rebirth
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| 53. | The One Trinket Game Break | 1,445 | | The Binding of Isaac: Rebirth
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| 54. | How to contract a cardiovascular disease while playing Isaac | 1,435 | | The Binding of Isaac: Rebirth
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| 55. | CO-OP CHAOS #shorts | 1,423 | | The Binding of Isaac: Rebirth
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| 56. | How Fast Can You Kill Beast?! #shorts | 1,384 | | The Binding of Isaac: Rebirth
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| 57. | MOST DANGEROUS MODDED CHARACTER - The Binding of Isaac: Epiphany [Tarnished Magdeline/Maggy] | 1,359 | | The Binding of Isaac: Rebirth
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| 58. | Why I LOVE GAMEBREAKS #shorts | 1,300 | | The Binding of Isaac: Rebirth
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| 59. | A Full Analysis/Guide of The Alt Floors - Do They Belong in Isaac? (2/2) | 1,291 | Guide | The Binding of Isaac: Rebirth
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| 60. | The 160 Room Floor | 1,279 | | The Binding of Isaac: Rebirth
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| 61. | Unlocking 30 Characters in your VERY FIRST Repentance Run - The Final Barrier | 1,252 | | The Binding of Isaac: Rebirth
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| 62. | How Many Mantle Shields Can You Have At Once? (NOT INFINITE) | 1,239 | | The Binding of Isaac: Rebirth
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| 63. | Who Is The Most FUN Repentance Character [PATCH 1.7.5] - TBOI Tier List | 1,229 | | The Binding of Isaac: Rebirth
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| 64. | We Need to Talk about Isaac Players.. | 1,218 | | The Binding of Isaac: Rebirth
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| 65. | How To Achieve GOD STRENGTH In Isaac. #shorts | 1,190 | | The Binding of Isaac: Rebirth
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| 66. | "Fair and Balanced" #shorts | 1,177 | | The Binding of Isaac: Rebirth
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| 67. | NyanTuber: Innocence Glitched | 1,144 | | The Binding of Isaac: Rebirth
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| 68. | How Fast Can You Beat "Cantripped"? | 1,127 | | The Binding of Isaac: Rebirth
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| 69. | [Hard Mode] FOUR PLAYER FILE - The Binding Of Isaac Repentance part 1 (mic issues ep 1-3) | 1,106 | | The Binding of Isaac: Rebirth
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| 70. | The Most Underrated Special Room In Isaac #shorts | 1,087 | | The Binding of Isaac: Rebirth
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| 71. | Game Changing NEW Secret Rooms! - Rare Secret Rooms | 1,078 | | The Binding of Isaac: Rebirth
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| 72. | How To Dodge "PLAN C" With One Life | 1,071 | Guide | The Binding of Isaac: Rebirth
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| 73. | How Fast Can You Beat "Backasswards"? | 1,071 | | The Binding of Isaac: Rebirth
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| 74. | This Mod is TWO GIGABYTES?! - Making Tainted Cain "Fun" | 1,069 | | The Binding of Isaac: Rebirth
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| 75. | WHY DOES THIS EXIST #shorts | 1,063 | | The Binding of Isaac: Rebirth
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| 76. | TAINTED UNBIDDEN - The Infinite Respawn Character! | 1,062 | | The Binding of Isaac: Rebirth
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| 77. | [WR] NEW TBOI Death% in .48 Seconds | 1,036 | | The Binding of Isaac: Rebirth
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| 78. | Isaac's TRUE Full Clear: Beating All 160 Red Rooms (Unseeded, No Debug) | 1,030 | | The Binding of Isaac: Rebirth
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| 79. | How to edit your Binding of Isaac Repentance saves to unlock and use Dead God! | 1,011 | Guide | The Binding of Isaac: Rebirth
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| 80. | Everything YOU Should know about ERROR ROOMS | 1,005 | | The Binding of Isaac: Rebirth
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| 81. | How I Beat 100 Floors in Less than 30 Minutes (100 Basement Speedrun) | 1,003 | | The Binding of Isaac: Rebirth
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| 82. | Unused/Hidden Repentance Content: Greed mode HUSH and ALT FLOORS (maybe future update) | 992 | Vlog | The Binding of Isaac: Rebirth
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| 83. | This Red Crawlspace is a SOFTLOCK!!! #shorts | 979 | | The Binding of Isaac: Rebirth
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| 84. | Everything YOU need to know about CREEP! | 976 | | The Binding of Isaac: Rebirth
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| 85. | First Floor Free Win #shorts | 948 | | The Binding of Isaac: Rebirth
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| 86. | What happens if you VOID R KEY and FORGET ME NOW... Then use it? | 937 | | The Binding of Isaac: Rebirth
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| 87. | They Made "Pride" A Bit TOO OP... #shorts | 914 | | The Binding of Isaac: Rebirth
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| 88. | No One Can Top My INSANE Nuzlocke Start... | 911 | | The Binding of Isaac: Rebirth
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| 89. | Three Golden Pills in ONE room on BASEMENT ONE | 881 | | The Binding of Isaac: Rebirth
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| 90. | The Elusive DOUBLE Godhead... | 878 | | The Binding of Isaac: Rebirth
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| 91. | C SECTION IS THE BOSS MELTER - "The Lost" [7/34] The Binding Of Isaac Iron Man | 866 | | The Binding of Isaac: Rebirth
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| 92. | One Hundred Damage Modded Synergy #shorts | 856 | | The Binding of Isaac: Rebirth
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| 93. | Ranking EVERY Repentance Item - The Binding of Isaac Tier List | 851 | | The Binding of Isaac: Rebirth
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| 94. | How Fast Can You Beat "Speed" in Isaac? | 848 | | The Binding of Isaac: Rebirth
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| 95. | The Secret Strongest Boss In Isaac | 846 | | The Binding of Isaac: Rebirth
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| 96. | Three Repentance WORLD RECORDS back to back to back [Set Seed] | 840 | | The Binding of Isaac: Rebirth
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| 97. | All Your HP Belongs to Me. #shorts | 830 | | The Binding of Isaac: Rebirth
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| 98. | The Binding of Isaac: Apocrypha | 821 | | The Binding of Isaac: Rebirth
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| 99. | Don't Skip Damocles #short | 815 | | The Binding of Isaac: Rebirth
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| 100. | ONE SHIELD, ONE SHOT - "The Baleful" [1/34] TBOI Iron Man Streak | 805 | | The Binding of Isaac: Rebirth
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