| 1. | What Happens If Isaac Gets 64 Polyphemus and 64 20/20 ? | 34 | | The Binding of Isaac: Rebirth
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| 2. | What Happens If Isaac Gets 64 Chocolate Milk or 64 Lucky Foot? | 33 | | The Binding of Isaac: Rebirth
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| 3. | What Happens If Isaac Gets 64 Tech X ? | 27 | | The Binding of Isaac: Rebirth
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| 4. | What Happens If Isaac Gets 64 Dr.Fetus? | 27 | | The Binding of Isaac: Rebirth
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| 5. | What Happens If Isaac Gets 64 Twisted Pair? | 25 | | The Binding of Isaac: Rebirth
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| 6. | What Happens If Isaac Gets 64 Mama Mega or 64 Capricorn? | 22 | | The Binding of Isaac: Rebirth
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| 7. | What Happens If Isaac Gets 64 Gemini? | 20 | | The Binding of Isaac: Rebirth
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| 8. | What Happens If Isaac Gets 64 Dead Bird or 64 Mini Mush ? | 20 | | The Binding of Isaac: Rebirth
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| 9. | What Happens If Isaac Gets 64 Monstro's Lung or 64 Buddy in a Box? | 20 | | The Binding of Isaac: Rebirth
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| 10. | What Happens If Isaac Gets 64 GodHead? | 19 | | The Binding of Isaac: Rebirth
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| 11. | What Happens If Isaac Gets 64 The Parasite or 64 Cricket's Body? | 19 | | The Binding of Isaac: Rebirth
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| 12. | What Happens If Isaac Gets 64 Technology? | 19 | | The Binding of Isaac: Rebirth
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| 13. | Giving Isaac synergy from the comments | 19 | | The Binding of Isaac: Rebirth
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| 14. | What Happens If Isaac Gets 64 Brimstone? | 19 | | The Binding of Isaac: Rebirth
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| 15. | What Happens If Isaac Gets 64 Soy Milk or 64 Lil Delirium? | 17 | | The Binding of Isaac: Rebirth
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| 16. | What Happens If Isaac Gets 64 Succubus? | 16 | | The Binding of Isaac: Rebirth
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| 17. | What Happens If Isaac Gets 64 C Section or 64 Cube of Meat? | 16 | | The Binding of Isaac: Rebirth
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| 18. | What Happens If Isaac Gets 64 Smart Fly or Many Other Items? | 16 | | The Binding of Isaac: Rebirth
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| 19. | What Happens If Isaac Gets 64 Haemolacria? | 16 | | The Binding of Isaac: Rebirth
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| 20. | What Happens If Isaac Gets 64 Judas' Shadow or 64 Incubus? | 15 | | The Binding of Isaac: Rebirth
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| 21. | What Happens If Isaac Gets All Angel Room Items ? | 15 | | The Binding of Isaac: Rebirth
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| 22. | What Happens If Isaac Gets All The Syringes? | 15 | | The Binding of Isaac: Rebirth
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| 23. | What Happens If Isaac Gets All items 4 Quality ? | 14 | | The Binding of Isaac: Rebirth
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| 24. | What Happens If Isaac Gets 64 Mom's Knife? | 14 | | The Binding of Isaac: Rebirth
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| 25. | What Happens If Isaac Gets All Charged Items? | 14 | | The Binding of Isaac: Rebirth
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| 26. | Weakest YouTuber Run Be Like: | 14 | | The Binding of Isaac: Rebirth
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| 27. | What Happens If Isaac Gets All Red Items? | 14 | | The Binding of Isaac: Rebirth
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| 28. | What Happens If Isaac Gets 64 The Halo? | 13 | | The Binding of Isaac: Rebirth
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| 29. | What Happens If Isaac Gets 64 Psy Fly? | 13 | | The Binding of Isaac: Rebirth
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| 30. | What Happens If Isaac Gets All the Mushrooms? | 13 | | The Binding of Isaac: Rebirth
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| 31. | What Happens If Isaac Gets 64 Cain's Other Eye? | 12 | | The Binding of Isaac: Rebirth
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| 32. | What Happens If Isaac Gets 64 Cricket's Head? | 11 | | The Binding of Isaac: Rebirth
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| 33. | What Happens If Isaac Gets 64 Magic Mushroom? | 11 | | The Binding of Isaac: Rebirth
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| 34. | What Happens If Isaac Gets All Trinkets From Rebirth? | 11 | | The Binding of Isaac: Rebirth
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| 35. | What Happens If Isaac Gets 64 The WIZ? | 11 | | The Binding of Isaac: Rebirth
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| 36. | What Happens If Isaac Gets 64 Ball Of Bandages? | 10 | | The Binding of Isaac: Rebirth
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| 37. | What Happens If Isaac Gets 64 Finger!? | 9 | | The Binding of Isaac: Rebirth
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| 38. | What Happens If Isaac Gets 64 Brother Bobby? | 9 | | The Binding of Isaac: Rebirth
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| 39. | What Happens If Isaac Gets ALL Friends? | 9 | | The Binding of Isaac: Rebirth
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| 40. | What Happens If Isaac Gets 64 Dead Cat? | 9 | | The Binding of Isaac: Rebirth
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| 41. | What Happens If Isaac Gets 64 Pisces? | 9 | | The Binding of Isaac: Rebirth
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| 42. | What Happens If Isaac Gets 64 Compound Fracture? | 9 | | The Binding of Isaac: Rebirth
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| 43. | What Happens If Isaac Gets 64 The Intruder? | 9 | | The Binding of Isaac: Rebirth
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| 44. | What Happens If Isaac Gets 64 My Reflection? | 9 | | The Binding of Isaac: Rebirth
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| 45. | What Happens If Isaac Gets 64 Jacob's Ladder or 64 Fruity Plum? | 9 | | The Binding of Isaac: Rebirth
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| 46. | What Happens If Isaac Gets 64 Holy Mantle or All Planetarium Items? | 8 | | The Binding of Isaac: Rebirth
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| 47. | What Happens If Isaac Gets 64 Freezer Baby? | 8 | | The Binding of Isaac: Rebirth
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| 48. | What Happens If Isaac Gets All signs of the Zodiac | 8 | | The Binding of Isaac: Rebirth
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| 49. | Weakest Tainted Keeper in Greedier Mod: | 8 | | The Binding of Isaac: Rebirth
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| 50. | I Complete The Challenge From The Comments | 8 | | The Binding of Isaac: Rebirth
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| 51. | What Happens If Isaac Gets 64 Pentagram? | 7 | | The Binding of Isaac: Rebirth
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| 52. | What Happens If Isaac Gets All Items 0 Quality? | 6 | | The Binding of Isaac: Rebirth
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| 53. | What Happens If Isaac Gets 64 Daddy Longlegs? | 6 | | The Binding of Isaac: Rebirth
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| 54. | What Happens If Isaac Gets 64 My Shadow or Shade? | 6 | | The Binding of Isaac: Rebirth
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| 55. | What Happens If Isaac Gets 64 Odd Mushroom(Thin)? | 6 | | The Binding of Isaac: Rebirth
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| 56. | What Happens If Isaac Gets 64 EXPERIMENTAL TREATMENT? | 6 | | The Binding of Isaac: Rebirth
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| 57. | What Happens If Isaac Gets 64 Hushy? | 5 | | The Binding of Isaac: Rebirth
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| 58. | Salvation Saved Me From Mother | 4 | | The Binding of Isaac: Rebirth
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| 59. | What Happens If Isaac Gets 64 Ipecac or 64 Keeper's Sack? | 4 | | The Binding of Isaac: Rebirth
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| 60. | What Happens If Isaac Gets 64 Almond Milk or 64 Strawman? | 4 | | The Binding of Isaac: Rebirth
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| 61. | What Happens If Isaac Gets 64 Guppy's Tail? | 4 | | The Binding of Isaac: Rebirth
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| 62. | What Happens If Isaac Gets All Spider Items? | 4 | | The Binding of Isaac: Rebirth
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| 63. | What Happens If Isaac Gets All Shop Items? | 3 | | The Binding of Isaac: Rebirth
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| 64. | Cursed Tainted Eden Run: | 3 | | The Binding of Isaac: Rebirth
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| 65. | Tainted Lilith be like: | 3 | | The Binding of Isaac: Rebirth
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| 66. | What Happens If Isaac Gets 64 Bloody Puppy? | 2 | | The Binding of Isaac: Rebirth
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| 67. | What Happens If Isaac Gets All Devil Room Items ? | 1 | | The Binding of Isaac: Rebirth
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| 68. | What Happens If Isaac Gets All Fly items? | 1 | | The Binding of Isaac: Rebirth
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| 69. | What Happens If Isaac Gets 64 Proptosis or Epic Fetus? | 0 | | The Binding of Isaac: Rebirth
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