| 1. | What Happens If Isaac Gets 64 Tech X ? | 38,946 | | The Binding of Isaac: Rebirth
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| 2. | What Happens If Isaac Gets 64 Dr.Fetus? | 23,380 | | The Binding of Isaac: Rebirth
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| 3. | What Happens If Isaac Gets 64 Brimstone? | 22,696 | | The Binding of Isaac: Rebirth
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| 4. | What Happens If Isaac Gets 64 Twisted Pair? | 17,800 | | The Binding of Isaac: Rebirth
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| 5. | What Happens If Isaac Gets 64 Polyphemus and 64 20/20 ? | 13,290 | | The Binding of Isaac: Rebirth
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| 6. | What Happens If Isaac Gets 64 Mom's Knife? | 11,678 | | The Binding of Isaac: Rebirth
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| 7. | What Happens If Isaac Gets 64 Chocolate Milk or 64 Lucky Foot? | 10,385 | | The Binding of Isaac: Rebirth
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| 8. | What Happens If Isaac Gets 64 Magic Mushroom? | 8,854 | | The Binding of Isaac: Rebirth
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| 9. | What Happens If Isaac Gets 64 Psy Fly? | 8,399 | | The Binding of Isaac: Rebirth
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| 10. | What Happens If Isaac Gets 64 EXPERIMENTAL TREATMENT? | 6,056 | | The Binding of Isaac: Rebirth
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| 11. | What Happens If Isaac Gets All The Syringes? | 5,906 | | The Binding of Isaac: Rebirth
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| 12. | What Happens If Isaac Gets All signs of the Zodiac | 5,744 | | The Binding of Isaac: Rebirth
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| 13. | What Happens If Isaac Gets 64 GodHead? | 4,929 | | The Binding of Isaac: Rebirth
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| 14. | What Happens If Isaac Gets 64 Technology? | 4,633 | | The Binding of Isaac: Rebirth
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| 15. | What Happens If Isaac Gets All Angel Room Items ? | 4,570 | | The Binding of Isaac: Rebirth
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| 16. | What Happens If Isaac Gets 64 Dead Bird or 64 Mini Mush ? | 4,478 | | The Binding of Isaac: Rebirth
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| 17. | What Happens If Isaac Gets All Devil Room Items ? | 4,156 | | The Binding of Isaac: Rebirth
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| 18. | What Happens If Isaac Gets All items 4 Quality ? | 3,860 | | The Binding of Isaac: Rebirth
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| 19. | What Happens If Isaac Gets 64 Daddy Longlegs? | 3,724 | | The Binding of Isaac: Rebirth
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| 20. | What Happens If Isaac Gets 64 The Parasite or 64 Cricket's Body? | 3,666 | | The Binding of Isaac: Rebirth
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| 21. | What Happens If Isaac Gets 64 Holy Mantle or All Planetarium Items? | 3,653 | | The Binding of Isaac: Rebirth
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| 22. | Giving Isaac synergy from the comments | 3,461 | | The Binding of Isaac: Rebirth
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| 23. | What Happens If Isaac Gets 64 Bloody Puppy? | 3,330 | | The Binding of Isaac: Rebirth
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| 24. | What Happens If Isaac Gets 64 C Section or 64 Cube of Meat? | 3,305 | | The Binding of Isaac: Rebirth
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| 25. | What Happens If Isaac Gets All Red Items? | 3,268 | | The Binding of Isaac: Rebirth
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| 26. | What Happens If Isaac Gets 64 Mama Mega or 64 Capricorn? | 3,259 | | The Binding of Isaac: Rebirth
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| 27. | Weakest Tainted Keeper in Greedier Mod: | 3,207 | | The Binding of Isaac: Rebirth
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| 28. | What Happens If Isaac Gets 64 Succubus? | 3,181 | | The Binding of Isaac: Rebirth
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| 29. | What Happens If Isaac Gets 64 My Reflection? | 2,877 | | The Binding of Isaac: Rebirth
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| 30. | What Happens If Isaac Gets All Charged Items? | 2,857 | | The Binding of Isaac: Rebirth
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| 31. | What Happens If Isaac Gets All Fly items? | 2,808 | | The Binding of Isaac: Rebirth
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| 32. | What Happens If Isaac Gets 64 The WIZ? | 2,807 | | The Binding of Isaac: Rebirth
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| 33. | What Happens If Isaac Gets 64 Jacob's Ladder or 64 Fruity Plum? | 2,802 | | The Binding of Isaac: Rebirth
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| 34. | What Happens If Isaac Gets 64 Finger!? | 2,701 | | The Binding of Isaac: Rebirth
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| 35. | What Happens If Isaac Gets 64 Judas' Shadow or 64 Incubus? | 2,692 | | The Binding of Isaac: Rebirth
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| 36. | Weakest YouTuber Run Be Like: | 2,679 | | The Binding of Isaac: Rebirth
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| 37. | What Happens If Isaac Gets 64 Ball Of Bandages? | 2,665 | | The Binding of Isaac: Rebirth
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| 38. | What Happens If Isaac Gets 64 Haemolacria? | 2,565 | | The Binding of Isaac: Rebirth
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| 39. | What Happens If Isaac Gets 64 Cricket's Head? | 2,564 | | The Binding of Isaac: Rebirth
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| 40. | What Happens If Isaac Gets 64 Almond Milk or 64 Strawman? | 2,545 | | The Binding of Isaac: Rebirth
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| 41. | What Happens If Isaac Gets 64 The Intruder? | 2,507 | | The Binding of Isaac: Rebirth
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| 42. | What Happens If Isaac Gets 64 Pisces? | 2,474 | | The Binding of Isaac: Rebirth
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| 43. | What Happens If Isaac Gets 64 My Shadow or Shade? | 2,474 | | The Binding of Isaac: Rebirth
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| 44. | What Happens If Isaac Gets 64 The Halo? | 2,463 | | The Binding of Isaac: Rebirth
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| 45. | What Happens If Isaac Gets 64 Soy Milk or 64 Lil Delirium? | 2,383 | | The Binding of Isaac: Rebirth
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| 46. | What Happens If Isaac Gets ALL Friends? | 2,339 | | The Binding of Isaac: Rebirth
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| 47. | What Happens If Isaac Gets All the Mushrooms? | 2,255 | | The Binding of Isaac: Rebirth
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| 48. | What Happens If Isaac Gets 64 Proptosis or Epic Fetus? | 2,222 | | The Binding of Isaac: Rebirth
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| 49. | What Happens If Isaac Gets All Trinkets From Rebirth? | 2,211 | | The Binding of Isaac: Rebirth
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| 50. | What Happens If Isaac Gets 64 Monstro's Lung or 64 Buddy in a Box? | 2,036 | | The Binding of Isaac: Rebirth
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| 51. | What Happens If Isaac Gets 64 Smart Fly or Many Other Items? | 2,034 | | The Binding of Isaac: Rebirth
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| 52. | What Happens If Isaac Gets 64 Pentagram? | 1,968 | | The Binding of Isaac: Rebirth
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| 53. | What Happens If Isaac Gets 64 Compound Fracture? | 1,945 | | The Binding of Isaac: Rebirth
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| 54. | What Happens If Isaac Gets All Spider Items? | 1,936 | | The Binding of Isaac: Rebirth
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| 55. | What Happens If Isaac Gets 64 Cain's Other Eye? | 1,935 | | The Binding of Isaac: Rebirth
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| 56. | What Happens If Isaac Gets 64 Brother Bobby? | 1,865 | | The Binding of Isaac: Rebirth
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| 57. | What Happens If Isaac Gets 64 Dead Cat? | 1,791 | | The Binding of Isaac: Rebirth
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| 58. | What Happens If Isaac Gets 64 Guppy's Tail? | 1,716 | | The Binding of Isaac: Rebirth
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| 59. | What Happens If Isaac Gets 64 Ipecac or 64 Keeper's Sack? | 1,582 | | The Binding of Isaac: Rebirth
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| 60. | What Happens If Isaac Gets 64 Gemini? | 1,579 | | The Binding of Isaac: Rebirth
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| 61. | What Happens If Isaac Gets All Items 0 Quality? | 1,579 | | The Binding of Isaac: Rebirth
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| 62. | What Happens If Isaac Gets 64 Odd Mushroom(Thin)? | 1,515 | | The Binding of Isaac: Rebirth
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| 63. | What Happens If Isaac Gets 64 Hushy? | 1,492 | | The Binding of Isaac: Rebirth
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| 64. | What Happens If Isaac Gets 64 Freezer Baby? | 1,398 | | The Binding of Isaac: Rebirth
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| 65. | What Happens If Isaac Gets All Shop Items? | 1,231 | | The Binding of Isaac: Rebirth
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| 66. | Cursed Tainted Eden Run: | 976 | | The Binding of Isaac: Rebirth
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| 67. | Salvation Saved Me From Mother | 772 | | The Binding of Isaac: Rebirth
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| 68. | I Complete The Challenge From The Comments | 288 | | The Binding of Isaac: Rebirth
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| 69. | Tainted Lilith be like: | 229 | | The Binding of Isaac: Rebirth
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