| 101. | Isaac Reads: Zen Shorts by Jon J Muth | 241 | |
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| 102. | emergency room, autoimmune, all hope is lost | 241 | |
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| 103. | trans person dies of blood clot from HRT | 240 | |
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| 104. | Game Devs: Body Type A / Body Type B - RANT | 233 | |
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| 105. | Do all men secretly want to be women??? | 230 | |
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| 106. | What is a TERF? | 241 | |
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| 107. | Artificial Intelligence | 223 | |
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| 108. | touching grass | 217 | |
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| 109. | girlfriend LEFT me in the DESERT to DIE ALONE | 209 | |
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| 110. | love and happiness, always (whisper) | 205 | |
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| 111. | i'm healthy and depressed :) | 196 | |
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| 112. | Reacting to Transgender Autoimmunity Case | 184 | |
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| 113. | Tea Tasting w/ Isaac - Ep. 1 | 183 | |
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| 114. | Fruit + Probiotics Day 1: This is gonna hurt | 179 | |
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| 115. | transgender rats & sugar is poison | 174 | |
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| 116. | TERFs are Insane!! (and reinforce gender stereotypes) | 184 | |
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| 117. | detransitioning thoughts, r/detrans, gender therapy, bpd, sleepy ramble nonsense | 167 | Vlog |
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| 118. | Oh I'm so sorry to hear that... | 161 | |
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| 119. | Fruit Day 2: How to Raise a Genius Child | 158 | |
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| 120. | yearning, missing what once was... 😟 | 157 | |
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| 121. | might be going psychotic or something idk | 152 | |
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| 122. | sugar psychosis | 151 | |
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| 123. | Nothing Left to Lose | 147 | |
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| 124. | Exclusive & Unreleased Pumpkins [The Director's Cut] | 146 | |
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| 125. | Blood Test Results - Body is dying + My detransition plan | 144 | |
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| 126. | Debunking the AI Rumors: The Real Isaac Speaks Out | 189 | |
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| 127. | Creep / I'm a Crepe (Cover by AIsaac 2.0) | 142 | |
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| 128. | Stinging Nettle - Tea Time Ep. 5 | 139 | | Nettle
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| 129. | i've lost everything i loved | 159 | |
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| 130. | Tulsi Tea Tuesday Taste Test | 133 | |
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| 131. | Yerba Mate, Fenugreek, Giloy Neem - Tea Time Ep. 3 | 132 | |
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| 132. | Pumpkin's Last Night Here | 127 | |
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| 133. | The Smiling Girl in Grippy Socks | 127 | |
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| 134. | Day 2 of Detransition: Things are going so h*ckin' good. I feel amazing. | 125 | |
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| 135. | White, Oolong, Matcha Tea - Tea Time Ep. 2 | 124 | |
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| 136. | Pixelgem - NFT Passion Project (Historic NFTs) | 122 | |
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| 137. | TERFs are Misandrists | 151 | |
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| 138. | mindfully eating peas and drinking water alone in a quiet room on a warm night | 116 | |
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| 139. | New Vagabond Friend :) | 108 | |
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| 140. | detransition, comfort, gender dysphoria, advice (bye) | 106 | |
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| 141. | 💜 No Negativity November #NNN | 126 | |
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| 142. | Björk: The Musical Sorceress Who Casts a Spell on Us All | 119 | |
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| 143. | Vanity | 101 | |
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| 144. | Favorite Candy: Jack Link's Beef Jerky #Carnivore #Keto #Yummy | 99 | | Carnivores
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| 145. | The Return of Doctor Pumpkin | 99 | |
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| 146. | White Matcha?! - Mad Tea Science Ep. 1 | 98 | |
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| 147. | Black Tea Battle - Tea Time Ep. 4 | 98 | |
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| 148. | Familial Guilt / Advice with Sam Hyde | 95 | |
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| 149. | Detrans - Day 989 of Detransition | 101 | |
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| 150. | Channel Update + Playing Runescape | 89 | Vlog | RuneScape
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| 151. | Goth explains blockchains, cryptocurrencies, and NFTs to you (POV) | 89 | |
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| 152. | Autoimmune & Suffering | 103 | |
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| 153. | Detrans Q&A | 83 | |
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| 154. | Ex-trans Sickly YouTuber Tries to Get Healthy | 98 | |
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| 155. | Fia - I Am (Cover by AIsaac 2.0) | 81 | |
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| 156. | Goodbye Pumpkin | 79 | |
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| 157. | I want to be on my own | 78 | |
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| 158. | i blocked my mom | 87 | |
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| 159. | Ayla Nereo - Stars (Cover by AIsaac 2.0) | 76 | |
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| 160. | happy, good things happening, validating, relieved | 76 | |
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| 161. | MY PUDDIN' LOVES ME SO 😍💜💜💜 | 81 | |
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| 162. | the best day ever!!! | 92 | |
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| 163. | Withdrawal from HRT - Fertility - Pain, Lethargy, Aching Joints, Headache - Feeling happy though :) | 75 | |
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| 164. | ASMR - Eating Raw Meat // Eating Sounds // Flesh // No Talking | 75 | |
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| 165. | ASMR Clothing Try On Haul | Ear to Ear, Softly Spoken | 82 | |
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| 166. | Introducing New Roommate & Addiction Discussion | 87 | |
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| 167. | Autoimmune eDiary 1 - Estrogen Deterioration + Depression | 68 | |
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| 168. | Can You Feel The Love Tonight (Cover by AIsaac 2.0) | 68 | |
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| 169. | estrogen x testosterone - final analysis | 68 | |
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| 170. | ASMR👨🏻💼 Ear Cleaning by a Mafia Boss💵 | 83 | |
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| 171. | detrans trending | 73 | |
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| 172. | ASMR for Alpha Males (No Girls Allowed) | 72 | Let's Play |
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| 173. | I Think I'm Turning AGP | 77 | |
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| 174. | finally telling the truth | 65 | |
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| 175. | ASMR Paranoid Boyfriend Interrogates You | Ear to Ear, Soft Speaking, Whisper | 68 | |
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| 176. | Yi Jian Mei (Cover by AIsaac 2.0) | 64 | |
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| 177. | Psychotic Autistic Narcissistic Transgender YouTuber Discusses Gay Concepts | 86 | |
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| 178. | Marvin Gaye - Let's Get It On (Cover by AIsaac 2.0) | 63 | |
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| 179. | i love you, bye for now | 65 | |
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| 180. | facts about me (important) | 76 | |
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| 181. | reality | 72 | |
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| 182. | I Will CURE Autoimmune Disease | 63 | |
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| 183. | Phase 4: Abduct | 63 | |
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| 184. | A.I. sings Still Alive (Cover by AIsaac 2.0) | 59 | |
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| 185. | at least they're consistent | 59 | |
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| 186. | ex-gf abandoned me for 4th time; might retransition. lol XD rekt | 59 | |
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| 187. | Identity, Ego, and Obsessive Thoughts about the Self | 58 | |
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| 188. | Terry Davis on "features" | 57 | |
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| 189. | Preston Joseph Wyatt | Reaction | 67 | |
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| 190. | Vanity - Magic Mirror | 56 | |
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| 191. | So Your Son is on Estrogen: A Dad's Guide to Hormone Therapy | 54 | Guide |
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| 192. | How I Became an Incel (Please Marry Me) | 91 | |
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| 193. | The Berries and Cream Diet | 60 | |
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| 194. | Hello my Chinese friends! / 你好我的中国朋友 | 59 | |
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| 195. | my girlfriend abandoned me | 51 | |
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| 196. | Phase 2: Command | 50 | |
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| 197. | never eating carbs again | 56 | |
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| 198. | vow of solitude & positivity | 50 | |
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| 199. | ASMR Serial Experiments Lain Iwakura (Wired) | 62 | |
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| 200. | The Greatest Gift I Ever Received #shorts #short #thankful #blessed | 61 | |
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